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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial显示文摘 | Femke Mol Norah M van Mello Annika Strandell Karin Strandell Davor Jurkovic Jackie Ross Kurt T Barnhart Tamer M Yalcinkaya Harold R Verhoeve Giuseppe C M Graziosi Carolien A M Koks Ingmar Klinte Lars Hogstr?m Ineke C A H Janssen Harry Kragt Annemieke Hoek | 2014 | The Lancet2014，，： | 2 |
| 3 | A lignan and pyrone and other constituents from Hyptis capitata 显示文摘 | Gunvor T A Alan C H Kurt B G T | 1991 | Phytochemistry1991，30，8： | 1 |
| 4 | Clinical behavior of solitary fibrous tumors of the pleura显示文摘 | de Perrot M Kurt A M Robert J H | 1999 | The Annals of thoracic surgery1999，67，5： | 1 |
| 5 | Evaluation of treatment and recovery of leachate by bipolar membrane electrodialysis process显示文摘 | Ilhan F Kabuk H A Kurt U | 2014 | Chemical Engineering and Processing: Process Intensification2014，75，： | 1 |
| 6 | Endothelial activation in ARDS显示文摘 | Guy A Zimmerman MD Kurt H | 1999 | Chest1999，116，1： | 1 |
| 7 | Artificial neural network application to the friction stir welding of aluminum plates 显示文摘 | OKUYUCU H KURT A ARCAKLIOGLU E | 2007 | Materials and Design2007，28，1： | 1 |
| 8 | Artificial neural network application to the friction stir welding of aluminum plates 显示文摘 | Okuyueu H Kurt A | 2007 | Materials and Design2007，28，： | 1 |
| 9 | Artificial neural network application to the friction stir welding of Al plates显示文摘 | KUYUCU H O KURT A E | 2007 | Mater Design2007，28，： | 1 |
| 10 | Poland's syndrome and gastric cancer:report of a case显示文摘 | KURT Y DEMIRBAS S ULUUTKU A H et el | 2006 | Eur J Cancer Prev2006，15，6： | 1 |
| 11 | Predicting the exterior durability of new fluoropolyer coating显示文摘 | Kurt A W Lotfi H Christopher C | 2000 | Journal of Fluorine Chemistry2000，104，1： | 1 |
| 12 | Predicting the exterior durability of new fluoropolymer coatings 显示文摘 | Kurt A W'Christopher C'Loti H | 2000 | Fluorine Chem2000，，104： | 1 |
| 13 | Kinetics of met hane oxdiation in landfill cover soil:Temporal variations,a whole landfill oxidiation experiment and modeling of net CH4 emiss-ions显示文摘 | J eane E B Kurt A S Elezabet h A B | | 0，，： | 1 |
| 14 | Manipulated Synchronization: Beam Steering in Phased Arrays 显示文摘 | Ted H Kurt W Robert A Y | 2000 | Int J Bifurc Chaos (S0218-1274)2000，10，11： | 1 |
| 15 | Artificial neural network ap-plication to the friction stir welding of aluminum plates显示文摘 | Okuyucu H Kurt A Arcaklioglu E | 2007 | Mate-rials and Design2007，28，1： | 1 |
| 16 | Sudden hearing loss due to large vestibular aqueduct syndrome in a child: should explora- tory tympanotomy be performed? 显示文摘 | Can IH Gocmen H Kurt/A | 2004 | Int J Pediatr Otorhino- laryngol2004，14，： | 1 |
| 17 | Differential effects of sex hormones and phytoestrogens on peak and steady state contractions in isolated rab- bitdetrusor显示文摘 | Paul H Rat Z Kurt A | 1999 | JUrol1999，162，5： | 1 |
| 18 | Predicting the exterior durability of new fluoropolymer coatings 显示文摘 | KURT A W CHRISTOPER C LOTFI H | 2000 | J Fluorine Chem2000，104，1： | 1 |
| 19 | Effectiveness of FK506 on lipid peroxidation in the spinal cord following experimental traumatic injury 显示文摘 | Kaymaz M Emmez H Bukan N Dursun A Kurt G Pasaoglu H | 2005 | Spinal Cord2005，43，： | 1 |
| 20 | An empirical test of environmental, organizational, and process factors affecting incremental and radical innovation 显示文摘 | Christine S K Dawn R D Kurt A H | 2003 | Journal of High Technology Management Research2003，14，1： | 1 |
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