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| 1 | PM 2.5 collected in a residential area induced Th1-type inflammatory responses with oxidative stress in mice显示文摘 | Eun-Jung Park Jinkyu Roh Younghun Kim Kwangsik Park Dae-Seon Kim Seong-Do Yu | 2010 | Environmental Research2010，，3： | 2 |
| 2 | Fault tolerance and QoS scheduling using CAN in mobile social cloud computing显示文摘 | SOOKKYONG C KWANGSIK C | 2014 | Cluster Computing2014，17，3： | 1 |
| 3 | Induction of pro-inflammatory signals by 1-nitropyrene in cultured BEAS-2B cells显示文摘 | Eun-Jung Park Kwangsik Park | 2008 | Toxicology Letters2008，，2： | 1 |
| 4 | Monitoring of ambient particles and heavy metals in a residential area of Seoul, Korea显示文摘 | Eun-jung Park Dae-seon Kim Kwangsik Park | 2008 | Environ Monit Assess2008，137，： | 1 |
| 5 | Asian Dust Storm and pulmonary function of school children in Seoul显示文摘 | Yun-Chul Hong Xiao-Chuan Pan Su-Young Kim Kwangsik Park Eun-Jung Park Xiaobin Jin Seung-Muk Yi Yoon-Hee Kim Choong-Hee Park Sanghwan Song Ho Kim | 2009 | Science of the Total Environment2009，，4： | 1 |
| 6 | Predictability of polygenic risk score for progression to dementia and its interaction with APOEε4 in mild cognitive impairment显示文摘Background:The combinatorial efect of multiple genetic factors calculated as a polygenic risk score(PRS)has been studied to predict disease progression to Alzheimer’s disease(AD)from mild cognitive impairment(MCI).Previous studies have investigated the performance of PRS in the prediction of disease progression to AD by including and excluding single nucleotide polymorphisms within the region surrounding the APOE gene.These studies may have missed the APOE genotype-specifc predictability of PRS for disease progression to AD.Methods:We analyzed 732 MCI from the Alzheimer’s Disease Neuroimaging Initiative cohort,including those who progressed to AD within 5 years post-baseline(n=270)and remained stable as MCI(n=462).The predictability of PRS including and excluding the APOE region(PRS_(+APOE) and PRS_(−APOE))on the conversion to AD and its interaction with the APOEε4 carrier status were assessed using Cox regression analyses.Results:PRS_(+APOE)(hazard ratio[HR]1.468,95%CI 1.335-1.615)and PRS_(−APOE)(HR 1.293,95%CI 1.157-1.445)were both associated with a signifcantly increased risk of MCI progression to dementia.The interaction between PRS_(+APOE) and APOEε4 carrier status was signifcant with a P-value of 0.0378.The association of PRSs with the progression risk was stronger in APOEε4 non-carriers(PRS_(+APOE):HR 1.710,95%CI 1.244-2.351;PRS_(−APOE):HR 1.429,95%CI 1.182-1.728)than in APOEε4 carriers(PRS_(+APOE):HR 1.167,95%CI 1.005-1.355;PRS_(−APOE):HR 1.172,95%CI 1.020-1.346).Conclusions:PRS could predict the conversion of MCI to dementia with a stronger association in APOEε4 noncarriers than APOEε4 carriers.This indicates PRS as a potential genetic predictor particularly for MCI with no APOEε4 alleles. | Jung‑Min Pyun Young Ho Park Keon‑Joo Lee SangYun Kim Andrew J.Saykin Kwangsik Nho | 2021 | Translational Neurodegeneration2021，10，3： | 0 |
| 7 | Myelin repair in Alzheimer’s disease:a review of biological pathways and potential therapeutics显示文摘This literature review investigates the significant overlap between myelin-repair signaling pathways and pathways known to contribute to hallmark pathologies of Alzheimer’s disease(AD).We discuss previously investigated therapeutic targets of amyloid,tau,and ApoE,as well as other potential therapeutic targets that have been empirically shown to contribute to both remyelination and progression of AD.Current evidence shows that there are multiple AD-relevant pathways which overlap significantly with remyelination and myelin repair through the encouragement of oligodendrocyte proliferation,maturation,and myelin production.There is a present need for a single,cohesive model of myelin homeostasis in AD.While determining a causative pathway is beyond the scope of this review,it may be possible to investigate the pathological overlap of myelin repair and AD through therapeutic approaches. | Lauren Rose Hirschfeld Shannon L.Risacher Kwangsik Nho Andrew J.Saykin | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
| 8 | Origin of non-uniform plasticity in a high-strength Al-Mn-Sc based alloy produced by laser powder bed fusion显示文摘The Al-Mn-Sc-based alloys specific for additive manufacturing(AM)have been recently developed and can reach ultrahigh strength and adequate elongation.However,these alloys commonly exhibit nonuniform plasticity during tensile deformation,which is a critical issue hindering their wider application.In this work,the origin of this non-uniform plasticity of the alloys produced by laser powder bed fusion(LPBF)has been systematically investigated for the first time.The results show that the loss of uniform plasticity in the alloy originates from microstructural regions containing equiaxed fine-grains(FGs)(~650nm in size)at the bottom of the melt pools.In micro-tensile tests,the strength of these FG regions can reach a peak of~630 MPa.After this,an apparent yield drop occurs,followed by rapid strain softening.This FG behavior is associated with intermetallic particles along grain boundaries and a lack of uniform mobile dislocations during deformation.The columnar coarse-grain(CG)regions in the remaining melt pools show uniform plasticity and moderate work hardening.Furthermore,the quantitative calculations indicate that the solid solution strengthening in these two regions is similar.Nevertheless,secondary Al_(3)Sc precipitates contribute to~260 MPa strength in the FG,compared to 310 MPa in the CG due to their different number density.In addition,grain boundary strengthening can reach 230 MPa in the FG region;nearly double the CG region value. | Dina Bayoumy Kwangsik Kwak Torben Boll Stefan Dietrich Daniel Schliephake Jie Huang Junlan Yi Kazuki Takashima Xinhua Wu Yuman Zhu Aijun Huang | 2022 | Journal of Materials Science & Technology2022，，8： | 0 |
| 9 | New Evidence for a Cretaceous Age for a Mesozoic Nonmarine Bivalve Assemblage from Paekto-dong, Sinuiju City, The Democratic People’s Republic of Korea显示文摘The Sinuiju Formation in Paekto-dong,Sinuiju City in the Democratic People's Republic of Korea has yielded Mesozoic nonmarine bivalve fossils,which is the first occurrence of such in the DPRK.Based on these fossil specimens,a new Cretaceous bivalve assemblage,the Arguniella yanshanensis-Sphaerium anderssoni Assemblage is erected.This assemblage includes Arguniella yanshanensis,A.lingyuanensis and Sphaerium anderssoni and can be compared with the Jehol Biota.The age of the Sinuiju Formation is also clarified and on the basis of the bivalves and the presence of a Eosestheria–Ephemeropsis–Lycoptera(E–E–L)assemblage,the formation is not Upper Jurassic,but Lower Cretaceous in age. | CholGuk WON KwangSik SO SuHyang JON | 2019 | Acta Geologica Sinica(English Edition)2019，93，6： | 0 |
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