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| 1 | Anti-osteoarthritis effect of a combination treatment with human adipose tissue-derived mesenchymal stem cells and thrombospondin 2 in rabbits显示文摘BACKGROUND Osteoarthritis(OA),a chronic age-related disease characterized by the slowly progressive destruction of articular cartilage,is one of the leading causes of disability.As a new strategy for treatment of OA,mesenchymal stem cells(MSCs)have the potential for articular cartilage regeneration.Meanwhile,thrombospondin 2(TSP2)promotes the chondrogenic differentiation of MSCs.AIM To investigate whether TSP2 induces chondrogenic differentiation of human adipose-derived MSCs(hADMSCs)and potentiates the therapeutic effects of hADMSCs in OA rabbits.METHODS We investigated the chondrogenic potential of TSP2 in hADMSCs by analyzing the expression of chondrogenic markers as well as NOTCH signaling genes in normal and TSP2 small interfering RNA(siRNA)-treated stem cells.Anterior cruciate ligament transection surgery was performed in male New Zealand white rabbits,and 8 wk later,hADMSCs(1.7×10^6 or 1.7×10^7 cells)were injected into the injured knees alone or in combination with intra-articular injection of TSP2(100 ng/knee)at 2-d intervals.OA progression was monitored by gross,radiological,and histological examinations.RESULTS In hADMSC culture,treatment with TSP2 increased the expression of chondrogenic markers(SOX9 and collagen Ⅱ)as well as NOTCH signaling genes(JAGGED1 and NOTCH3),which were inhibited by TSP2 siRNA treatment.In vivo,OA rabbits treated with hADMSCs or TSP2 alone exhibited lower degree of cartilage degeneration,osteophyte formation,and extracellular matrix loss 8 wk after cell transplantation.Notably,such cartilage damage was further alleviated by the combination of hADMSCs and TSP2.In addition,synovial inflammatory cytokines,especially tumor-necrosis factor-α,markedly decreased following the combination treatment.CONCLUSION The results indicate that TSP2 enhances chondrogenic differentiation of hADMSCs via JAGGED1/NOTCH3 signaling,and that combination therapy with hADMSCs and TSP2 exerts synergistic effects in the cartilage regeneration of OA joints. | Kyungha Shin Yeseul Cha Young-Hwan Ban Da Woom Seo Ehn-Kyoung Choi Dongsun Park Sung Keun Kang Jeong Chan Ra Yun-Bae Kim | 2019 | World Journal of Stem Cells2019，11，12： | 2 |
| 2 | Missed lesions in synchronous multiple gastric cancer显示文摘 | Tae KyungHa Ji YeongAn Ho GeunYoun Min GewChoi Jae HyungNoh Tae SungSohn SungKim | 2010 | ANZ Journal of Surgery2010，，4： | 1 |
| 3 | Diamond-like carbon protective anti-reflection coating for Si solar cell 显示文摘 | Won S C Kyunghae K Junsin Y | 2008 | Materials Letters2008，62，： | 1 |
| 4 | 18F-fluorodeoxyglucose-positron emission tomography and computed tomography is not accurate in preoperative staging of gastric cancer显示文摘 | Tae KyungHa Yun Young Choi Soon Young | 2011 | J Korean Surg Soc2011，81，2： | 1 |
| 5 | Selective emitter using porous silicon for crystalline silicon solar cells显示文摘 | Inyong Moon Kyunghae Kim M. Thamilselvan Youngkuk Kim Kyumin Han Doheon Kyeong Taeyoung Kwon Dao Vinh Ai Jeongchul Lee Minkyu Ju Kyungsoo Lee Junsin Yi | 2008 | Solar Energy Materials and Solar Cells2008，，6： | 1 |
| 6 | Low cost CBD ZnS antireflection coating on large area commercial mono-crystalline silicon solar cells 显示文摘 | Gangopadhyay U Kyunghae K Mangalaraj D | 2004 | Applied Surface Science2004，230，14： | 1 |
| 7 | Tex-turing of large area multi-crystalline silicon wafers throughdifferent chemical approaches for solar cell fabrication显示文摘 | Kyunghae Kim Dhungel S K Sungwook Jung D etal | 2008 | So-lar energy materialssolar cells2008，，92： | 1 |
| 8 | Texturing of large area multi-crystalline silicon wafers through different chemical approaches for solar cell fabrication 显示文摘 | KYUNGHAE K DHUNGELA S K JUNG S | 2008 | Solar Energy Materials and Solar Cells2008，82，8： | 1 |
| 9 | Ethanol extracts of unroasted Coffea canephora robusta beans suppress adipogenesis in preadipocytes and fat accumulation in rats fed a high-fat diet显示文摘 | Jihyun Kim Ja Young Jang Jingmei Cai Youngeun Kim Kyungha Shin Ehn-Kyoung Choi Sung-Pyo Lee Jong-Choon Kim Tae-Su Kim Heon-Sang Jeong Yun-Bae Kim | 2014 | Food Science and Biotechnology2014，，： | 1 |
| 10 | Role of hydrazine monohydrate during texturization of large-area crystalline silicon solar cell fabrication显示文摘 | Gangopadhyay U Kyunghae Kim Ajoy Kandol | 2006 | Sol Energy Mater Sol Cells2006，90，： | 1 |
| 11 | Looking towards the Future of BIM in South Korea Towards AI-Enhanced BIM显示文摘This paper provides an overview of South Korea’s 20-year journey in adopting building information modeling(BIM) and future direction. It first discusses the six phases of BIM adoption in South Korea, starting from the use of BIM as a marketing tool to its current intelligent BIM phase. The government’s support for BIM-related research and development projects is also highlighted, with a focus on the artificail intelligence (AI)-based architectural design automation project. As the future direction, it explores the integration of AI with BIM in both local and global contexts. The paper presents AIpowered architectural design methods, including AI-powered early architectural design generation and architectural detailing.Compared to AI-based early architectural design generation, architectural detailing is an unexplored research topic. This paper introduces two AI-and BIM-based architectural detailing methods, being developed at Yonsei University:namely,BIM library transplant and Natural language-based Architectural Detailing through Interaction with AI (NADIA). These methods demonstrate how AI-enhanced BIM can enable architects to interactively develop building details using a language model as a conversational AI and a knowledge base, and a BIM authoring tool as a design platform, in the near future. | Ghang Lee Suhyung Jang Kyungha Lee Munchel Kim | 2023 | 土木建筑工程信息技术2023，15，4： | 0 |
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