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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Tolyporphins J and K,two further porphinoid metabolites from the cyanobacterium tolypothrix nodosa 显示文摘 | Prinsep M R Patterson G M L Larsen L K | 1998 | J Nat Prod1998，61，： | 2 |
| 3 | CO methanation over supported bimetallic Ni-Fe catalysts: From computational studies towards catalyst optimization 显示文摘 | Kustov A L Frey A M Larsen K E | 2007 | Appl Catal A2007，320，： | 1 |
| 4 | Monofocal outer retinitis associated with hand,foot,and mouth disease caused by coxsackievirus显示文摘 | Kessel L Larsen M | 2000 | Am J Ophthalmol2000，129，： | 1 |
| 5 | Molecular identification and characterization of novel coronaviruses infecting graylag geese (Anser anser), feral pigeons (Columbia livia) and mallards (Anas platyrhynchos) 显示文摘 | Jonasseo C M Kofstad T Larsen I L | 2005 | J Gen Virol2005，86，： | 1 |
| 6 | Incidence of bacteremia after chew- ing, tooth brushing and scaling in individuals with periodontal inflammation 显示文摘 | Foruer L Larsen T Kilian M | 2006 | J Clin Periodontal2006，33，6： | 1 |
| 7 | Lipidated alpha- peptide/beta-peptoid hybrids with potent anti-inflammatory activity显示文摘 | Skovbakke S L Larsen C J Heegaard P M | 2015 | Journal of medicinal chemistry2015，，： | 1 |
| 8 | Helium isotope composition of the early Iceland mantle plume inferred from the Tertiary picrites of West Greenland显示文摘 | LARSEN L M HANAN B B | 1998 | Earth Planet Sci Lett1998，160，： | 1 |
| 9 | Automated detection of subpixel hyperspectral targets with continuous and discrete wavelet 显示文摘 | Bruce L M Morgan C Larsen S | 2001 | IEEE Transaction on Geoscience and Remote Sensing2001，39，10： | 1 |
| 10 | Incidence of bacteremia af- ter chewing, tooth brushing and scaling in individuals with perio- dontal inflammation 显示文摘 | Fomer L Larsen T Kilian M | 2006 | J Clin Periodontol2006，33，6： | 1 |
| 11 | The role of computed tomography for localization of parathyroid adenomas显示文摘 | Zald P B Hamilton B E Larsen M L | 2008 | Laryngoscope2008，118，8： | 1 |
| 12 | Further tolyporphins from the blue-green alga tolypothrix nodosa 显示文摘 | Prinsep M R Patterson G M L Larsen L K | 1995 | Tetrahedron1995，51，10： | 1 |
| 13 | Fate and transport of 17fl-estradiol in soil-water systems 显示文摘 | Casey F X M Larsen G L Hakk H | 2003 | Environ Sci Technol2003，37，11： | 1 |
| 14 | Temperature and concentration control over interpenetration in a metal-organic material显示文摘 | Zhang J J Wojtas L Larsen R W Eddaoudi M Zaworotko M J | | 0，，： | 1 |
| 15 | Analysis of AKS-and lanthana-doped molybdenum wire 显示文摘 | IORIO L E BEWLAY B P LARSEN M | 2006 | International Journal of Refractory Metals and Hard Materials2006，24，： | 1 |
| 16 | Storage of Shell Eggs Influences the Albumen Gelling Properties显示文摘 | Hammershoj M Larsen L B Andersen A B | 2002 | LWT - Food Science and Technology2002，35，1： | 1 |
| 17 | Incidence of bac- teremia after chewing, tooth brushing and scaling in indi- viduals with periodontal inflammation显示文摘 | Forner L Larsen T Kilian M | 2006 | J Clin Periodontol2006，33，6： | 1 |
| 18 | Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation 显示文摘 | Forner L Larsen T Kilian M | 2006 | J Clin Periodontol2006，33，6： | 1 |
| 19 | A Half Century of Mate Preferences:The Cultural Evolution of Values显示文摘 | Buss D M Shackelford T K Kirkpatrick L and Larsen R J | 2001 | Journal of Comparative Family Studies2001，63，2： | 1 |
| 20 | Fate and transport of 17β- estradiol in soil-water system显示文摘 | Casey F X M Larsen G L Hakk H | 2003 | Environmental Science and Technology2003，37，11： | 1 |
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