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| 1 | Patterns of local recurrence in rectal cancer after a multidisciplinary approach显示文摘Improvements in surgery and the application of combined approaches to fight rectal cancer have succeeded in reducing the local recurrence (LR) rate and when there is LR it tends to appear later and less often in isolation. Moreover, a subtle change in the distribution of LRs with respect to the pelvis has been observed. In general terms, prior to total mesorectal excision the most common LRs were central types (perianastomotic and anterior) while lateral and posterior forms (presa-cral) have become more common since the growth in the use of combined treatments. No differences have been reported in the current pattern of LRs as a function of the type of approach used, that is, neo-adjuvant therapies (short-term or long-course radiotherapy, orchemoradiotherapy versus extended lymphadenectomy, though there is a trend towards posterior or presacral LR in patients in the Western world and lateral LR in Asia. Nevertheless, both may arise from the same mechanism. Moreover, as well as the mode of treatment, the type of LR is related to the height of the initial tumor. Nowadays most LRs are related to the advanced nature of the disease. Involvement of the circumferential radial margin and spillage of residual tumor cells from lymphatic leakage in the pelvic side wall are two plausible mechanisms for the genesis of LR. The patterns of pelvic recurrence itself (pelvic subsites) also have important implications for prognosis and are related to the potential success of salvage curative approach. The re-operability for cure and prognosis are generally better for anastomotic and anterior types than for presacral and lateral recurrences. Overall survival after LR diagnosis is lower with radio or chemoradiotherapy plus optimal surgery approaches, compared to optimal surgery alone. | Jose M Enríquez-Navascués Nerea Borda Aintzane Liz-erazu Carlos Placer Jose L Elosegui Juan P Ciria Adelaida Lacasta Luis Bujanda | 2011 | World Journal of Gastroenterology2011，17，13： | 14 |
| 2 | C-reactive protein and other predictors of poor outcome in patients hospitalized with exacerbations of chronic obstructive pulmonary disease显示文摘 | Ruiz-Gonzalez A Lacasta D Ibarz M | 2008 | Respirology2008，13，7： | 1 |
| 3 | Cellular immunity in ASFV responses显示文摘 | Haru-Hisa Takamatsu Michael S. Denyer Anna Lacasta Catrina M.A. Stirling Jordi M. Argilaguet Christopher L. Netherton Christ A.L. Oura Carlos Martins Fernando Rodríguez | 2012 | Virus Research2012，，： | 1 |
| 4 | C-reactive protein and other predictors of poor outcome in patients hospitalized with exacerbations of chronic obstructive pulmonary disease 显示文摘 | Ruiz-Gonzalez A Lacasta D Ibarz M | 2008 | Respirology2008，13，7： | 1 |
| 5 | Expression library immunization can confer protection against lethal challenge with African swine fever virus显示文摘 | Lacasta A Ballester M Monteagudo P L | 2014 | Journal of Virology2014，88，13： | 1 |
| 6 | A Web Ontology Service to facilitate interoperability within a Spatial Data Infrastructure:Applicability to discovery显示文摘 | Lacasta J Nogueras-Iso J Béjar R | 2007 | Data & Knowledge Engineering2007，63，3： | 1 |
| 7 | Chiral Imprinting with Amino Acids of Ordered Mesoporous Silica Exhibiting Enantioselectivity after Calcination显示文摘 | LACASTA S SEBASTI(A)N V C CASADO C | | 0，，05： | 1 |
| 8 | C -reactive protein and other predictors of poor outcome in patients hospitalized with exacerbations of chronic obstructive pulmonary disease显示文摘 | Ruiz -Gonzalez A Lacasta D Ibarz M | 2008 | Respirology2008，13，7： | 1 |
| 9 | Talgo automatic gauge change system for freight wagons显示文摘 | Lopez Gomez J L Lacasta Alsa J | 2001 | Proceedings of the Institution of Mechanical Engineers Part F: Journal of Rail and Rapid Transit2001，215，1： | 1 |
| 10 | Effects of Different Management Practices on Soil Conservation and Soil Water in a Rainfed Olive Orchard显示文摘 | HERNANDEZ A J LACASTA C PASTOR J | 2005 | Agricultural Water Management2005，77，123： | 1 |
| 11 | Thermal Study of Low-grade Magnesium Hydroxide Used as Fire Re- tardant and in Passive Fire Protection显示文摘 | Formosa J Chimenos J M Lacasta A M | 2011 | Therrnochimica Ac- ta2011，515，12： | 1 |
| 12 | Effects of different management practices on soil conservation and soil water in a rainfed olive orchard显示文摘 | Hernandez A J Lacasta C Pastor J | 2005 | Agricultural Water Management2005，77，： | 1 |
| 13 | Effects of different man- agement practices on soil conservation and soil water in a rain- fed olive orchard显示文摘 | Hernandez A J Lacasta C Pastor J | 2005 | Agricultural Water Management2005，77，13： | 1 |
| 14 | ThManager: An Open Source Tool for Creating and Visualizing SKOS显示文摘 | Javier Lacasta etc | 2007 | Information Technology and Libraries2007，，3： | 1 |
| 15 | A comparison of several measurement scales for assessing dyspnea in there daily activities in patients with chronic obstructive pulmonary disease 显示文摘 | Ruiz de Ona Lacasta JM Puente Maestu L Rodriguez Hermosa JL | 2000 | Arch Sronconeumol2000，36，1： | 1 |
| 16 | Effects of different management practices on soil conservation and soil water in a rainfed olive orchard 显示文摘 | Hernandez A J Lacasta C Pastor J | 2005 | Agricultural Water Management2005，77，： | 1 |
| 17 | Raided crop energy balance of different fanning systems and crop rotations in a semi-arid environment : Results of a long-term trial显示文摘 | MORENO M M LACASTA C MECO R | 2011 | Soil and Tillage Research2011，114，1： | 1 |
| 18 | Expression library immunization can confer protection against lethal challenge with African swine fever virus显示文摘 | Lacasta A Ballester M Monteagudo P L | 2014 | Joumal of Virol- ogy2014，88，13： | 1 |
| 19 | Vagus indigestion resulting from a Cysticercus tenuicollis cyst in an adult ewe显示文摘 | Lacasta D Climent M Ferre R | 2013 | Small Ruminant Res2013，110，1： | 1 |
| 20 | Effects of different management practices on soil conservation and soil water in a rainfed olive orchard显示文摘 | A.J. Hernández C. Lacasta J. Pastor | 2005 | Agricultural Water Management2005，，1： | 1 |
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