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| 1 | Role of surface defects of carbon nanotubes on catalytic performance of barium promoted ruthenium catalyst for ammonia synthesis显示文摘Carbon nanotubes(CNTs) with abundant surface defects are prepared by a liquid oxidation and thermal annealing method. The defective CNTs-D supported Ba–Ru/CNTs-D catalysts exhibit superior catalytic performance in ammonia synthesis with a TOF be increased up to 0.30 s-1, which is 2.5 times of oxidized CNTs-O supported Ba–Ru/CNTs-O catalysts and 5 times of the Ba–Ru/CNTs. The characterizations by CO chemisorption, transmission electron microscope, Raman, and X-ray photoelectron spectroscopy revealed that the uniformly well dispersed Ru NPs can be stabilized on the defective sites of CNTs-D. The great improvement of the catalytic performance and stability of the Ba–Ru/CNTs-D is contributed to the strong interaction between Ru NPs and surface defect of the CNTs. | Yongcheng Ma Guojun Lan Wenzhao Fu Ying Lai Wenfeng Han Haodong Tang Huazhang Liu Ying Li | 2020 | Journal of Energy Chemistry2020，29，2： | 2 |
| 2 | Bacteroides ovatus-mediated CD27^(−)MAIT cell activation is associated with obesity-related T2D progression显示文摘Type 2 diabetes(T2D)is highly associated with obesity.However,the factors that drive the transition from excessive weight gain to glucose metabolism disruption are still uncertain and seem to revolve around systemic immune disorder.Mucosal-associated invariant T(MAIT)cells,which are innate-like T cells that recognize bacterial metabolites,have been reported to be altered in obese people and to lead to metabolic dysfunction during obesity.By studying the immunophenotypes of blood MAIT cells from a cross-sectional cohort of obese participants with/without T2D,we found an elevation in CD27^(-)negative(CD27−)MAIT cells producing a high level of IL-17 under T2D obese conditions,which could be positively correlated with impaired glucose metabolism in obese people.We further explored microbial translocation caused by gut barrier dysfunction in obese people as a triggering factor of MAIT cell abnormalities.Specifically,accumulation of the bacterial strain Bacteroides ovatus in the peripheral blood drove IL-17^(-)producing CD27−MAIT cell expansion and could be associated with T2D risk in obese individuals.Overall,these results suggest that an aberrant gut microbiota–immune axis in obese people may drive or exacerbate T2D.Importantly,CD27−MAIT cell subsets and Bacteroides ovatus could represent targets for novel interventional strategies.Our findings extend current knowledge regarding the clinical relevance of body mass index(BMI)-associated variation in circulating MAIT cells to reveal the role of these cells in obesity-related T2D progression and the underlying cellular mechanisms. | Yue Li Yi Yang Jin Wang Peihong Cai Mei Li Xixiang Tang Ying Tan Yuchan Wang Fan Zhang Xiaofeng Wen Qiaoxing Liang Yuanpeng Nie Tufeng Chen Xiang Peng Xuemin He Yanhua Zhu Guojun Shi Wai WCheung Lai Wei Yanming Chen Yan Lu | 2022 | Cellular & Molecular Immunology2022，19，7： | 2 |
| 3 | Experimental investigation on the wing-wake interaction at the mid stroke in hovering flight of dragonfly显示文摘This paper focuses on flow structures of the wing-wake interaction between the hind wing and the wake of the forewing in hovering flight of a dragonfly since there are arguments whether the wing-wake interaction is useful or not.A mechanical flapping model with two tandem wings is used to study the interaction.In the device,two identical simplified model wings are mounted to the flapping model and they are both scaled up to keep the Reynolds number similar to those of dragonfly in hovering flight since our experiment is conducted in a water tank.The kinetic pattern of dragonfly(Aeschna juncea) is chosen because of its special interesting asymmetry.A multi-slice phase-locked stereo particle image velocimetry(PIV) system is used to record flow structures around the hind wing at the mid downstroke(t/T=0.25) and the mid upstroke(t/T=0.75).To make comparison of the flow field between with and without the influence of the wake,flow structures around a single flapping wing(hind wing without the existence of the forewing) at these two stroke phases are also recorded.A local vortex identification scheme called swirling strength is applied to determine the vortices around the wing and they are visualized with the iso-surface of swirling strength.This paper also presents contour lines of z at each spanwise position of the hind wing,the vortex core position of the leading edge vortex(LEV) of hind wing with respect to the upper surface of hind wing,the circulation of the hind wing LEV at each spanwise position and so on.Experimental results show that dimension and strength of the hind wing LEV are impaired at the mid stroke in comparison with the single wing LEV because of the downwash from the forewing.Our results also reveal that a wake vortex from the forewing traverses the upper surface of the hind wing at the mid downstroke and its distance to the upper surface is about 40% of the wing chord length.At the instant,the distance of the hind wing LEV to the upper surface is about 20% of the wing chord length.Thus,there must be a wing-wake interaction mechanism that makes the wake vortex become an additional LEV of the hind wing and it can partly compensate the hind wing for its lift loss caused by the downwash from the forewing. | LAI GuoJun SHEN GongXin | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，11： | 2 |
| 4 | Wind tunnel investigation of different engine layouts of a blended-wing-body transport显示文摘A 2%scale,cruising version of a 450-seat class Blended-Wing-Body(BWB)transport was tested in the China Aerodynamic Research and Development Center’s FL-262.4-by-2.4-meter subsonic wind tunnel.The focus of the wind tunnel test was to investigate the aerodynamic performance of the latest BWB transport design,which would also aid in choosing a final engine arrangement in the three most potential engine integration layouts.The wind tunnel model can be tested with and without the nacelle and has three sets of different nacelle/tail integration positions.Computational Fluid Dynamics(CFD)simulations were performed in engine-aircraft integration design to find appropriate nacelle installing parameters of each layout.The comparison of CFD with experimental results shows good agreement.Wind tunnel measurements indicate that the tail-mounted engine layout produces the minimum drag penalty,while the fuselage-mounted engine layout increases drag the most.Experimental pressure measurement illustrates the effect of nacelle integration on the wing-body surface pressure distribution.This experimental and numerical research provides a reference for future BWB Propulsion-Airframe Integration(PAI)design. | Zheng CUI Guojun LAI Qifeng WANG Yu LIANG Yihua CAO | 2023 | Chinese Journal of Aeronautics2023，36，9： | 0 |
| 5 | Significant histological changes are not rare in indeterminate‐phase chronic hepatitis B patients with hepatitis B e antigen‐negative and normal alanine aminotransferase levels显示文摘Background&Objectives:The degree of liver injury in indeterminate chronic hepatitis B(CHB)infection patients with Hepatitis B e antigen(HBeAg)‐negative and persistently normal alanine aminotransferase(PNALT)levels is yet unclear.Therefore,we aimed to assess liver histological changes in such patients by liver biopsy and explore possible predictors.Methods:Overall,711 HBeAg‐negative CHB patients with PNALT levels who underwent liver biopsy from January 2017 to June 2022 were included in this retrospective study.The relationships between histological changes and predictors were assessed by smooth curve fitting and multivariate logistic regression analysis models.Data were also analyzed using American Association for the Study of Liver Disease(AASLD)modified alanine aminotransferase(ALT)criteria.Results:The proportion of significant histological changes in the indeterminate phase was higher than that in the inactive phase(53.97%vs.41.33%).The adjusted odds ratios(aORs)of significant necroinflammation and histological changes for the indeterminate phase were 2.05 and 1.43,respectively,when compared with the inactive phase by multivariate logistic regression analyses.Significant histological changes in the‐phase were positively associated with age,ALT,Aspartate aminotransferase(AST),Hepatitis B surface antigen(HBsAg),and Hepatitis B virus(HBV)DNA levels but negatively correlated with platelet(PLT)levels.HBV DNA≥5 log10 U/L and PLT<200�109/L were independent predictive factors for assessing histological changes in indeterminate‐phase patients.Similar analysis findings were obtained using the two sets of modified ALT criteria.Conclusions:Significant histological changes are not rare in indeterminatephase CHB patients and are higher than in the inactive phase,regardless of the ALT criteria.Histological investigation is strongly suggested for intermediate stage patients with HBV DNA>5 log10 U/L or PLT<200�109/L and antiviral therapy should be considered for such patients. | Deliang Huang Guangde Zhou Jinghan Peng Qinxian Cai Guojun Li Hong Yu Zhibing Zhu Yuanyuan Chen Huiyi Lai Jinyan Jiang Hong Yu Jun Chen | 2023 | iLABMED2023，1，3： | 0 |
| 6 | Study of A Stable High Power W-band Gyrotron Traveling Wave Tube Amplifier显示文摘 | LAI Guojun JIA Yunfeng LIU Pukun | 2005 | Chinese Journal of Electronics2005，14，4： | 0 |
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