| 1 | Application of Blockchain Sharding Technology in Chinese Medicine Traceability System显示文摘Traditional Chinese Medicine(TCM)is one of the most promising programs for disease prevention and treatment.Meanwhile,the quality of TCM has garnered much attention.To ensure the quality of TCM,many works are based on the blockchain scheme to design the traceability scheme of TCM to trace its origin.Although these schemes can ensure the integrity,sharability,credibility,and immutability of TCM more effectively,many problems are exposed with the rapid growth of TCM data in blockchains,such as expensive overhead,performance bottlenecks,and the traditional blockchain architecture is unsuitable for TCM data with dynamic growth.Motivated by the aforementioned problems,we propose a novel and lightweight TCM traceability architecture based on the blockchain using sharding(LBS-TCM).Compared to the existing blockchain-based TCM traceability system,our architecture utilizes sharding to develop a novel traceability mechanism that supports more convenient traceability operations for TCM requirements such as uploading,querying,and downloading.Specifically,our architecture consists of a leader shard blockchain layer as its main component,which employs a sharding mechanism to conveniently TCM tracing.Empirical evaluations demonstrated that our architecture showed better performance in many aspects compared to traditional blockchain architectures,such as TCM transaction processing,TCM transaction querying,TCM uploading,etc.In our architecture,tracing TCM has become a very efficient operation,which ensures the quality of TCM and provides great convenience for subsequent TCM analysis and retrospective research. | Fuan Xiao Tong Lai Yutong Guan Jiaming Hong Honglai Zhang Guoyu Yang Zhengfei Wang | 2023 | Computers, Materials & Continua2023，，7： | 0 |
| 2 | Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellular carcinoma with liver cirrhosis显示文摘Postoperative hepatic insulin-like growth factor-1(IGF-1)production may be severely disturbed in patients with liver cirrhosis.Complex alterations in the GH/IGF-1 axis are thought to play an important role in the protein catabolism that complicates major surgical procedures.The aim of this study was to explore the effects of parenteral nutrition(PN)with and without growth hormone(GH)on the GH/IGF-1 axis after hepatectomy for hepatocellular carcinoma(HCC)with cirrhosis and evaluate the potential roles of recombinant human GH(rhGH)therapy.Twenty-four patients with HCC with cirrhosis who underwent hepatectomy were randomly divided into two groups:a PN group(n=12)and an rhGH+PN group(n=12).Liver function,serum GH,IGF-1 and IGFBP-3 were measured before the operation and at postoperative days(POD)1 and 6.Insulin-like growth factor-1 and IGFBP-3 mRNA in the liver tissue was detected by RT-PCR.The liver Ki67 immunohistochemistry staining was studied.At the same time,12 patients with cholelithiasis or liver hemangioma who underwent operation served as normal control group.On POD 6,serum prealbumin,GH,IGF-1,IGFBP-3,hepatic IGF-1 mRNA,IGFBP-3 mRNA and liver Ki67 LI were higher in the rhGH+PN group than in the PN group.There was no significant difference in the 6-and 12-month tumor-free survival rate and the median tumor-free survival time between the PN group and the rhGH+PN group(P>0.05).These data indicate that rhGH+PN could ameliorate the changes in the GH/IGF-1 axis after hepatectomy for HCC in the setting of cirrhosis. | CAO Jie LUO Shimin LIANG Lijian LAI Jiaming CHEN Shanming | 2007 | Frontiers of Medicine2007，1，3： | 0 |
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