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| 1 | Lysine-specific demethylase 1 inhibitor rescues the osteogenic ability of mesenchymal stem cells under osteoporotic conditions by modulating H3K4 methylation显示文摘Bone tissue engineering may be hindered by underlying osteoporosis because of a decreased osteogenic ability of autologous seed cells and an unfavorably changed microenvironment in these patients. Epigenetic regulation plays an important role in the developmental origins of osteoporosis; however, few studies have investigated the potential of epigenetic therapy to improve or rescue the osteogenic ability of bone marrow mesenchymal stem cells(BMMSCs) under osteoporotic conditions. Here, we investigated pargyline, an inhibitor of lysine-specific demethylase 1(LSD1), which mainly catalyzes the demethylation of the di- and mono-methylation of H3K4. We demonstrated that 1.5 mmol·L^(- 1)pargyline was the optimal concentration for the osteogenic differentiation of human BMMSCs. Pargyline rescued the osteogenic differentiation ability of mouse BMMSCs under osteoporotic conditions by enhancing the dimethylation level of H3K4 at the promoter regions of osteogenesis-related genes. Moreover, pargyline partially rescued or prevented the osteoporotic conditions in aged or ovariectomized mouse models, respectively. By introducing the concept of epigenetic therapy into the field of osteoporosis, this study demonstrated that LSD1 inhibitors could improve the clinical practice of MSC-based bone tissue engineering and proposes their novel use to treat osteoporosis. | Longwei Lv Wenshu Ge Yunsong Liu Guanyou Lai Hao Liu Wenyue Li Yongsheng Zhou | 2016 | Bone Research2016，4，4： | 11 |
| 2 | DBPM signal processing with field programmable gate arrays显示文摘DBPM system performance is determined by the design and implementation of beam position signal processing algorithm.In order to develop the system,a beam position signal processing algorithm is implemented on FPGA.The hardware is a PMC board ICS-1554A-002(GE Corp.)with FPGA chip XC5VSX95T.This paper adopts quadrature frequency mixing to down convert high frequency signal to base.Different from conventional method,the mixing is implemented by CORDIC algorithm.The algorithm theory and implementation details are discussed in this paper.As the board contains no front end gain controller,this paper introduces a published patent-pending technique that has been adopted to realize the function in digital logic.The whole design is implemented with VHDL language. An on-line evaluation has been carried on SSRF(Shanghai Synchrotron Radiation Facility)storage ring.Results indicate that the system turn-by-turn data can measure the real beam movement accurately,and system resolution is 1.1μm. | LAI Longwei LENG Yongbin YI Xing YAN Yingbing ZHANG Ning YANG Guisen WANG Baopeng XIONG Yun | 2011 | Nuclear Science and Techniques2011，22，3： | 10 |
| 3 | RF front-end for digital beam position monitor signal processor显示文摘RF circuit board has a significant impact on performance of the Digital Beam Position Monitor (DBPM) in storage ring of a synchrotron radiation facility.In this paper,a front-end RF board is designed for DBPM,and schematics of the RF board and the test results are given.In view of the inevitable inconsistency in the multi-channel circuit,a calibration circuit is designed to reduce such an influence.The test results show that the calibration method is useful for beam current dependence which is sensitive to channels inconsistency. | YI Xing LENG Yongbin LAI Longwei ZHANG Ning YANG Guisen | 2011 | Nuclear Science and Techniques2011，22，2： | 4 |
| 4 | A beam position measurement system of fully digital signal processing at SSRF显示文摘This fully digital beam position measurement instrument is designed for beam position monitoring and machine research in Shanghai Synchrotron Radiation Facility. The signals received from four position-sensitive detectors are narrow pulses with a repetition rate up to 499.654 MHz and a pulse width of around 100 ps, and their dynamic range could vary over more than 40 dB in machine research. By the employment of the under-sampling technique based on high-speed high-resolution A/D conversion, all the processing procedure is performed fully by the digital signal processing algorithms integrated in one single Field Programmable Gate Array. This system functions well in the laboratory and commissioning tests, demonstrating a position resolution (at the turn by turn rate of 694 kHz) better than 7 μm over the input amplitude range of -40 dBm to 10 dBm which is well beyond the requirement. | YAN Han ZHAO Lei LIU Shubin CHEN Kat WU Weihao AN Qi LENG Yongbin YI Xing YAN Yingbing LAI Longwei | 2012 | Nuclear Science and Techniques2012，23，2： | 3 |
| 5 | An embedded single-board computer for BPM of SSRF显示文摘An embedded single-board computer (SBC) system based on AT91RM9200 was designed for monitoring and controlling the digital beam position monitor system of Shanghai Synchrotron Radiation Facility (SSRF) through the Virtex-4 FPGA in the digital processing board.The SBC transfers the configuration commands from the remote EPICS to the FPGA,and calculates the beam position data.The interface between the FPGA and the SBC is the Static Memory Controller (SMC) with a peak transfer speed of up to 349 Mbps.The 100 Mb Ethernet is used for data transfer between the EPICS and SBC board,and a serial port serves as monitoring the status of the embedded system.Test results indicate that the SBC board functions well. | CHEN Kai LIU Shubin YAN Han WU Weihao ZHAO Lei AN Qi LENG Yongbin YI Xing YAN Yingbing LAI Longwei | 2011 | Nuclear Science and Techniques2011，22，4： | 0 |
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