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| 1 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 2 | Serum humanepididymis protein 4 vs carbohydrate antigen 125 for ovariancancer diagnosis显示文摘 | Ferrar S Braga F Lanzoni M | 2013 | Clin Pathol2013，66，4： | 1 |
| 3 | An embedded portable biosensor system for bacterial concentration detection显示文摘 | GROSSI M LANZONI M POMPEI A | | 0，，03： | 1 |
| 4 | Serum human epididymis protein 4 vs carbohydrate antigen125 for ovarian cancer diagnosis:a systematic review显示文摘 | Ferraro S Braga F Lanzoni M | 2013 | Clin Pathol2013，66，： | 1 |
| 5 | Serum human epidid- ymis protein 4 vs carbohydrate antigen 125 for ovarian cancer diagnosis: a systematic review显示文摘 | Ferraro S Braga F Lanzoni M | 2013 | J Clin Pathol2013，66，4： | 1 |
| 6 | Carcinosarcoma of the liver:A case report显示文摘 | Garcez-Silva M H Gonzalez A M Moura R A Linhares M M Lanzoni V P Trivino T | 2006 | Transplant Proc2006，38，： | 1 |
| 7 | Morphological equilibrium of short channels dissecting the tidal fiats of coastal lagoons显示文摘 | Toffolon M Lanzoni S | 2010 | J Geophys Res2010，115，04： | 1 |
| 8 | Advanced electrical-level modeling of EEPROM cells显示文摘 | Lanzoni M Sune J Olivo P | 1993 | Electron Devices1993，40，5： | 1 |
| 9 | Adherence to statin therapy and patients' cardiovascular risk: a pharmacoepidemiological study in Italy显示文摘 | Poluzzi E Strahinja P Lanzoni M | 2008 | Eur J Clin Pharmacol2008，64，4： | 1 |
| 10 | Spontaneous tidal network formation within a constructed salt marsh: observations and morphodynamic modelling显示文摘 | D'Alpaos A Lanzoni S Marani M | 2007 | Geomorphology2007，91，3： | 1 |
| 11 | A simple method for iden- tifying bone marrow mesenchymal stromal cells with a high immu- nosuppressive potential 显示文摘 | Rizzo R Lanzoni G Stignani M | 2011 | Cytotherapy2011，13，5： | 1 |
| 12 | Tidal network ontogeny: Channel initiation and early development 显示文摘 | D'Alpaos A Lanzoni S Marani M | 2005 | Journal of Geophysical Research: Earth Surface (2003-2012)2005，110，2： | 1 |
| 13 | The calcium-channel blocker lacidipine reduces the development of atherosclerotic lesions in the apoE-deficient mouse显示文摘 | Cristofori P Lanzoni A Quartaroli M | 2000 | J Hypertens2000，18，10： | 1 |
| 14 | RNA expression induced by cisplatin in an organ of Corti-derived immortalized cell line显示文摘 | Previati M Lanzoni I Corbacella E | 2004 | Hear Res2004，196，： | 1 |
| 15 | Modeling the influence of hydroperiod and vegetation on the cross-section formation of tidal channels显示文摘 | D'ALPAOS A LANZONI S MUDD S M | 2006 | Estuarine Coast and Shelf Science2006，69，： | 1 |
| 16 | Serum human epididymis protein 4 vs carbohydrate antigen 125 for ovarian cancer diagnosis 显示文摘 | FERRARO S BRAGA F LANZONI M | 2013 | Clin Patho12013，66，4： | 1 |
| 17 | The calcium-channel blocker lacidipine reduces the development of atherosclerotic lesions in the apoE-deficient mouse 显示文摘 | Cristofofi P Lanzoni A Quartaroli M | 2000 | J Hypertens2000，18，10： | 1 |
| 18 | RNA expression induced by cisplatin in an organ of Corti-defived immortalized cell line 显示文摘 | Previati M Lanzoni I Corbacella E | 2004 | Hear Res2004，196，12： | 1 |
| 19 | Serum human epididymisprotein 4 vs carbohydrate antigen 125 for ovarian cancer diagnosis :a systematic review 显示文摘 | Ferraro S Braga F Lanzoni M | 2013 | J Clin Pathol2013，66，4： | 1 |
| 20 | The calcium-channel blocker laciclipinc reduces the develpment of atherosclecrotic lesions in the apoEdeficient mouse 显示文摘 | Cristofori P Lanzoni A Quartaroli M | 2000 | J Hypertens2000，18，10： | 1 |
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