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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Tolyporphins J and K,two further porphinoid metabolites from the cyanobacterium tolypothrix nodosa 显示文摘 | Prinsep M R Patterson G M L Larsen L K | 1998 | J Nat Prod1998，61，： | 2 |
| 3 | Molecular identification and characterization of novel coronavlruses infecting graylag geese, feral pigeons and mallards显示文摘 | Christine H I Kofstad T Larsen I L | 2005 | Journal of General Virology2005，86，： | 1 |
| 4 | CO methanation over supported bimetallic Ni-Fe catalysts: From computational studies towards catalyst optimization 显示文摘 | Kustov A L Frey A M Larsen K E | 2007 | Appl Catal A2007，320，： | 1 |
| 5 | Discovery of technical methanation catalysts based on computational screening显示文摘 | Sehested J Larsen K E Kustov A L | 2007 | Topics in Catalysis2007，45，： | 1 |
| 6 | Persistence and fate of 17- estradiol and testosterone in agricultural soils显示文摘 | Z Fan FXM Casey G L Larsen | 2007 | Chemosphere2007，67，： | 1 |
| 7 | Vibrio anguillarum resistance to rainbow trout (Oncorhynchus mykiss) serum: Role of O-antigen structure of lipopolysaccharide显示文摘 | Boesen H T Pedersen K Larsen J L | 1999 | Infect Immun1999，67，1： | 1 |
| 8 | Tidally driven sediment transport on the East China Sea continental shelf显示文摘 | Sternberg R W Larsen L H Miao Y T | 1985 | Continental Shelf Research1985，4，1： | 1 |
| 9 | Monofocal outer retinitis associated with hand,foot,and mouth disease caused by coxsackievirus显示文摘 | Kessel L Larsen M | 2000 | Am J Ophthalmol2000，129，： | 1 |
| 10 | Suppressors of cytokine signaling:SOCS显示文摘 | Larsen L Ropke C | 2002 | APMIS2002，110，12： | 1 |
| 11 | A randomized controlled trial of asoprisnil, a novel se- lective progesterone receptor modulator, in women with u- terine leiomyoma 显示文摘 | CHWALISZ K LARSEN L MATYIA-GOLDBERG C | 2007 | Fertility And Sterility2007，87，6： | 1 |
| 12 | Molecular identification and characterization of novel coronaviruses infecting graylag geese (Anser anser), feral pigeons (Columbia livia) and mallards (Anas platyrhynchos) 显示文摘 | Jonasseo C M Kofstad T Larsen I L | 2005 | J Gen Virol2005，86，： | 1 |
| 13 | 3-D elastic numerical modeling of a complex salt structure显示文摘 | House L Larsen S Bednar J B | 2000 | SEG Expanded Abstracts2000，19，： | 1 |
| 14 | Incidence of bacteremia after chew- ing, tooth brushing and scaling in individuals with periodontal inflammation 显示文摘 | Foruer L Larsen T Kilian M | 2006 | J Clin Periodontal2006，33，6： | 1 |
| 15 | Measurements of the wind stress, heat flux, and turbulence intensity during storm con- ditions over the North Sea显示文摘 | Geernaert G L Larsen S E Hansen F | 1987 | Journal of Geophysical Research1987，92，13： | 1 |
| 16 | Lipidated alpha- peptide/beta-peptoid hybrids with potent anti-inflammatory activity显示文摘 | Skovbakke S L Larsen C J Heegaard P M | 2015 | Journal of medicinal chemistry2015，，： | 1 |
| 17 | Helium isotope composition of the early Iceland mantle plume inferred from the Tertiary picrites of West Greenland显示文摘 | LARSEN L M HANAN B B | 1998 | Earth Planet Sci Lett1998，160，： | 1 |
| 18 | Trimodal island distribution of Ge nanodots on (001)Si显示文摘 | Balle J Hansen J L Larsen A N | 2006 | J Appl Phys2006，100，06： | 1 |
| 19 | Automated detection of subpixel hyperspectral targets with continuous and discrete wavelet 显示文摘 | Bruce L M Morgan C Larsen S | 2001 | IEEE Transaction on Geoscience and Remote Sensing2001，39，10： | 1 |
| 20 | Vibrio damsela as a pathogenic agent causing mortality in cultured turbot (Scophthalmus maximus)显示文摘 | FOUZ B LARSEN J L TORANZO A E | 1991 | Bull Eur Assoc Fish Pathol1991，11，： | 1 |
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