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| 1 | Wnt signaling and Loxl2 promote aggressive osteosarcoma显示文摘Osteosarcoma(OS)is the most frequent primary malignant bone tumor in urgent need of better therapies.Using genetically modified mouse models(GEMMs),we demonstrate that Wnt signaling promotes c-Fos-induced OS formation via the actions of the collagen-modifying enzyme Loxl2.c-Fos/AP-1 directly regulates the expression of the Wnt ligands Wnt7b and Wnt9a in OS cells through promoter binding,and Wnt7b and Wnt9a in turn promote Loxl2 expression in murine and human OS cells through the transcription factors Zeb1 and Zeb2.Concordantly,inhibition of Wnt ligand secretion by inactivating the Wnt-less(Wls)gene in osteoblasts in c-Fos GEMMs either early or in a therapeutic setting reduces Loxl2 expression and progression of OS.Wls-deficient osteosarcomas proliferate less,are less mineralized and are enriched in fibroblastic cells surrounded by collagen fibers.Importantly,Loxl2 inhibition using either the pan-Lox inhibitor BAPN or a specific inducible shRNA reduces OS cell proliferation in vitro and decreases tumor growth and lung colonization in murine and human orthotopic OS transplantation models.Finally,OS development is delayed in c-Fos GEMMs treated with BAPN or with specific Loxl2 blocking antibodies.Congruently,a strong correlation between c-FOS,LOXL2 and WNT7B/WNT9A expression is observed in human OS samples,and c-FOS/LOXL2 co-expression correlates with OS aggressiveness and decreased patient survival.Therefore,therapeutic targeting of Wnt and/or Loxl2 should be considered to potentiate the inadequate current treatments for pediatric,recurrent,and metastatic OS. | Kazuhiko Matsuoka Latifa Bakiri Lena I.Wolff Markus Linder Amanda Mikels-Vigdal Ana Patiño-García Fernando Lecanda Christine Hartmann Maria Sibilia Erwin F.Wagner | 2020 | Cell Research2020，30，10： | 5 |
| 2 | Systematic review and meta-analysis on the association of tuberculosis in Crohn's disease patients treated with tumor necrosis factor-α inhibitors(Anti-TNFα)显示文摘AIM To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis(TB) infection in Crohn's disease(CD) patients treated with tumor necrosis factoralpha(TNFα) inhibitors.METHODS A meta-analysis of randomized, double-blind, placebocontrolled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction(EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds.RESULTS Twenty-three clinical trial studies were identified, including 5669 patients. Six TB infection cases were reported across 5 studies, all from patients receiving TNFα inhibitors. Eighteen studies reported no TB infection cases in placebo and TNFα inhibitor treatment arms. TB infection risk was significantly increased among patients receiving TNFα inhibitors, with a risk difference of 0.028(95%CI: 0.0011-0.055). The odds ratio was 4.85(95%CI: 1.02-22.99) with EBC and 5.85(95%CI: 1.13-30.38) without EBC.CONCLUSION The risk of TB infection is higher among CD patients receiving TNFα inhibitors. Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly Mycobacterium avium subspecies paratuberculosis, which ultimately could worsen their clinical condition. | Brent L Cao Ahmad Qasem Robert C Sharp Latifa S Abdelli Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，25： | 4 |
| 3 | Assessment of renal insufficiency in gestational proteinuric hypertension in third trimester pregnancy显示文摘 | Khatun A Latifa S Shahla K | 2003 | Bangladesh Med Res Counc Bull2003，29，3： | 1 |
| 4 | RANKL/OPG in primary cultures of osteoblasts from post-menopausal women. Differences between osteoporotic hip fractures and osteoarthritis显示文摘 | Mercè Giner M a José Rios M a José Montoya M a Angeles Vázquez Latifa Naji Ramón Pérez-Cano | 2008 | Journal of Steroid Biochemistry and Molecular Biology2008，，1： | 1 |
| 5 | A comparative study between laparoscopically assisted vaginal hysterectomy and total abdominal hysterectomy in patients with type2 diabetes显示文摘 | Jahan Samsad Akter Latifa Baki A | 2009 | Journal of Gynecologic Surgery2009，25，4： | 1 |
| 6 | Effects of organic acids and salts on the development of Penicillium italicum:The Causal Agent of Citrus Blue Mold显示文摘 | Latifa A Idriss T Hassan B | 2011 | Plant Pathology Journal2011，10，3： | 1 |
| 7 | Assessment of renal insufficiency in gestational protein uric hypertension in third trimester pregnancy 显示文摘 | Khatun A Latifa S Shahla K | 2003 | Bangladesh Med Res Counc Bull2003，29，3： | 1 |
| 8 | Electrochemical and SEM study on Type 254 SMO stainless steel in chloride solutions显示文摘 | Abd E1 Meguid E A Abd E1 LatifA A | 2004 | Corrosion Science2004，46，10： | 1 |
| 9 | CFAR threshold optimization by EMS-GA in non homogeneous backgrounds显示文摘 | Latifa A Faouzi S | 2006 | Asian Journal of Information Technology2006，5，12： | 1 |
| 10 | Effects of organic acids and salts on the development of Penicillium italicum: the causal agent of citrus blue mold 显示文摘 | LATIFA A IDRISS T HASSAN B | 2011 | Plant Pathology Journal2011，10，3： | 1 |
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