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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Free cupric ion concentration and Cu speciation in a eutrophic lake显示文摘 | XUE H B LAURA S | 1993 | Limnol Oceanogr1993，38，6： | 1 |
| 3 | Biologicalmarkers for evaluation of root resorption显示文摘 | Laura B Amsaveni R J ianjun H | 2007 | Arch Oral Biol2007，52，3： | 1 |
| 4 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 5 | Seed bank formation during early secondary succession in a temperate deciduous forest 显示文摘 | Laura A H Brenda B C | 2000 | Journal of Ecology2000，88，： | 1 |
| 6 | The chemistry of suspended particulate material in a highly contarninated embayment of port Jackson(Australia) under quiescent,high-wind and heavy-rainfall conditions显示文摘 | Gavin B Laura O H | | 0，，03： | 1 |
| 7 | Association between high - risk human papilloma virus DNA load and pre - cursor lesions of cervical cancer in Mexican women 显示文摘 | DULCE M H LAURA O B MIRIAM G J | 2003 | Gyne Onco2003，90，： | 1 |
| 8 | Measuring core- stability显示文摘 | Wendell P L Ted A B Laura H G | 2005 | J Strength Condres2005，19，3： | 1 |
| 9 | Wolbachia:master manipulators of invertebrate biology显示文摘 | Werren J H Laura B Clark M E | 2008 | Nature Reviews Microbiology2008，6，10： | 1 |
| 10 | Defective Rac-mediated proliferation and survival after targeted mutation of the β1 integrin cytodomain显示文摘 | Emilio H Laura B Mara B | 2002 | J Cell Biol2002，157，3： | 1 |
| 11 | Who are the Active Investors:Evidence from Venture Capital 显示文摘 | Bottazzi B Laura M Marco D R Thomas H | 2008 | Journal of Fi-nancial Economics2008，，3： | 1 |
| 12 | Nanosilver Particle Effects on Drug Metabolism In Vitro 显示文摘 | JOHN G L LAURA B H MARK A M | 2010 | Drug Metab Dispos2010，38，12： | 1 |
| 13 | Association belwen high risk human papillomarirus DNA load and precursor Lesions of lervical cancer in Mexican women显示文摘 | DULEE M H LAURA O B MIRIAM G J | 2003 | Gyno Onco2003，90，： | 1 |
| 14 | Endogenous mechanisms of neuroprotection : role of zinc, copper, and carnosine 显示文摘 | Michelle S H Laura J B Paul Q T | 2000 | Brain Research2000，852，： | 1 |
| 15 | A critical review of priority setting in the health sector: the methodology of the 1993 world development report显示文摘 | Waria P Henk B Laura H | 1993 | Health Policy and Planning1993，13，： | 1 |
| 16 | Measuring core stability显示文摘 | WENDELLPL TED A B LAURA H G | | 0，，03： | 1 |
| 17 | Sleep disturbance in hospi- talized recipients of stem cell transplantation 显示文摘 | Laura B Karen H Sarah J | 2011 | Clinical Journal of Oncology Nursing2011，15，3： | 1 |
| 18 | Computer networks as social net- works : collaborative work, telework, and virtual communit), 显示文摘 | WELLMAN B JANET S DIMITRINA D LAURA G MILE- NA G CAROLINE H | 1996 | Annual Review of Sociology1996，22，： | 1 |
| 19 | In vitro cytotoxicity of nanoparticles in mammalian germline stem cells显示文摘 | Laura B Saber H John J | 2005 | Toxicological Sciences2005，88，： | 1 |
| 20 | Coupled phasetransfor- mation,chemical decomposition, and deformation in plastic- bonded explosive: Simulations 显示文摘 | Valeryl L Bryan F H Laura B S etal | 2007 | Journal of Applied Physics2007，102，10： | 1 |
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