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| 1 | New therapeutic options opened by the molecular classification of gastric cancer显示文摘Gastric cancer(GC) is one of the most lethal and aggressive cancers, being the third cause of cancer related death worldwide. Even with radical gastrectomy and the latest generation of molecular chemotherapeutics, the numbers of recurrence and mortality remains high. This is due to its biological heterogeneity based on the interaction between multiple factors, from genomic to environmental factors, diet or infections with various pathogens. Therefore, understanding the molecular characteristics at a genomic level is critical to develop new treatment strategies. Recent advances in GC molecular classification provide the unique opportunity to improve GC therapy by exploiting the biomarkers and developing novel targeted therapy specific to each subtype. This article highlights the molecular characteristics of each subtype of gastric cancer that could be considered in shaping a therapeutic decision, and also presents the completed and ongoing clinical trials addressed to those targets. The implementation of the novel molecular classification system will allow a preliminary patient selection for clinical trials, a mandatory issue if it is desired to test the efficacy of a certain inhibitor to the given target. This will represent a substantial advance as well as a powerful tool for targeted therapy. Nevertheless, translating the scientific results into new personalized treatment opportunities is needed in order to improve clinical care, the survival and quality of life of patients with GC. | Mihaela Chivu-Economescu Lilia Matei Laura G Necula Denisa L Dragu Coralia Bleotu Carmen C Diaconu | 2018 | World Journal of Gastroenterology2018，24，18： | 14 |
| 2 | Therapies targeting cancer stem cells: Current trends and future challenges显示文摘Traditional therapies against cancer, chemo- and radiotherapy, have multiple limitations that lead to treatment failure and cancer recurrence. These limitations are related to systemic and local toxicity, while treatment failure and cancer relapse are due to drug resistance and self-renewal, properties of a small population of tumor cells called cancer stem cells(CSCs). These cells are involved in cancer initiation, maintenance, metastasis and recurrence. Therefore, in order to develop efficient treatments that can induce a longlasting clinical response preventing tumor relapse it is important to develop drugs that can specifically target and eliminate CSCs. Recent identification of surface markers and understanding of molecular feature associated with CSC phenotype helped with the design of effective treatments. In this review we discuss targeting surface biomarkers, signaling pathways that regulate CSCs self-renewal and differentiation, drug-efflux pumps involved in apoptosis resistance, microenvironmental signals that sustain CSCs growth, manipulation of mi RNA expression, and induction of CSCs apoptosis and differentiation, with specific aim to hamper CSCs regeneration and cancer relapse. Some of these agents are under evaluation in preclinical and clinical studies, most of them for using in combination with traditional therapies. The combined therapy using conventional anticancer drugs with CSCs-targeting agents, may offer a promising strategy for management and eradication of different types of cancers. | Denisa L Dragu Laura G Necula Coralia Bleotu Carmen C Diaconu Mihaela Chivu-Economescu | 2015 | World Journal of Stem Cells2015，7，9： | 10 |
| 3 | Land -cover change model validation by an ROC method for the lpswichwatershod, Massachusetts,USA显示文摘 | Pontius R G Jr Laura C S | 2001 | Agriculture Ecosystems and Environment2001，8，5： | 1 |
| 4 | Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors显示文摘 | Laura C Luciana G Alessandro G | 2001 | PNAS2001，98，11： | 1 |
| 5 | Wallerian degeneration : an e- merging axon death pathway linking injury and disease 显示文摘 | Laura C Jonathan G Coleman MP | 2014 | Nature Reviews Neuroscience2014，15，： | 1 |
| 6 | HPLC residues of enrofloxacin and ciprofloxacin in eggs of layings hens显示文摘 | NORA G ENRIQUE C LAURA U | 1997 | International Journal of Antimicrobial Agents1997，8，： | 1 |
| 7 | Influence of red mud,zeolite and lime on heavy metal immobilization, culturableheterotrophic microbial populations and enzyme activitiesin a contaminated soil显示文摘 | Giovanni G Paola C Laura S | 2007 | Geoderma2007，142，： | 1 |
| 8 | Influence of red mud, zeolite and lime on heavy metal immobilization, culturable heterotrophic microbial populations and enzyme activities in a contaminated soil显示文摘 | GIOVANNI G PAOLA C LAURA S | 2007 | Geoderma2007，142，12： | 1 |
| 9 | Micromechanical adhesion force measurements between hydrate particles in hydrocarbon oils and their modifications显示文摘 | Laura E D Zachary M A Nathan C G | 2009 | Energy Fuels2009，23，： | 1 |
| 10 | Expression of Iipoprotein lipase in ovaries of the guinea pig 显示文摘 | Laura C Mats G Manuel R | 1990 | Biol Reprod1990，42，： | 1 |
| 11 | The impact of urban development on hydrologic regime from catchment to basin scales 显示文摘 | Yang G Laura C B Keith A C | 2011 | Landsc Urban Plan2011，103，： | 1 |
| 12 | Land cover change model validation by an ROC method for the Ipswich watershed,Massachusetts,USA显示文摘 | Pontius R G Jr Schneider Laura C | 2001 | Agriculture Ecosystems and Environment2001，85，： | 1 |
| 13 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 14 | Sorption of As, Cd and Tl as influenced by industrial by-products applied to an acidic soil : equilibrium and kinetic experiments 显示文摘 | JAVIER A C FERMANDO G LAURA B | 2006 | Chemosphere2006，65，11： | 1 |
| 15 | Effect of inhibitors released during steam-explosion treatment of poplar wood on subsequent enzymatic hydrolysis and SSF显示文摘 | Maria C Laura C Alberto G | 2004 | Biotechnology Progress2004，20，1： | 1 |
| 16 | Land-cover change model Validation by an ROC method for Ipswich Watershed,Massachusetts显示文摘 | PONTIUS G G JR LAURA C S | 2001 | USA Agriculture Ecosystems and Environment2001，85，： | 1 |
| 17 | Neural stem cells and cholinergic neurons:Regulation by immunolesion and treatment with mitogens,retinoic acid,and nerve growth factor显示文摘 | Laura C Alessandro G Mercedes F | 2003 | Pnas2003，100，12： | 1 |
| 18 | 查看详情显示文摘 | Rachman C Laura B David G B | | 0，，9： | 1 |
| 19 | Influence of red mud,zeolite and lime on heavy metal immobilization,culturable hetero- trophlc microbial populations and enzyme activities in a contaminated soil显示文摘 | Giovanni G Paola C Laura S | 2007 | Geoderma2007，1427，： | 1 |
| 20 | Endothelial protection by high-density lipoproteins : from bench to bedside 显示文摘 | Laura C Monica G Guido E | 2003 | Arterioscler Thromb Vase Biol2003，23，： | 1 |
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