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| 1 | Hygiene hypothesis in inflammatory bowel disease: A criticalreview of the literature显示文摘The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hypothesis in IBD is unclear. We aimed to systematically review the literature to determine which hygiene-related factors are associated with the development of IBD. Publications identified from a broad based MEDLINE and Current Contents search between 1966 and 2007 on key terms relevant to the 'hygiene hypothesis' and IBD including H pylori exposure, helminths, cold chain hypothesis, measles infection and vaccination, antibiotic use, breastfeeding, family size, sibship, urban upbringing, day care attendance and domestic hygiene were reviewed. The literature suggests that the hygiene hypothesis and its association with decreased microbial exposure in childhood probably plays an important role in the development of IBD, although the strength of the supporting data for each of the factors varies considerably. The most promising factors that may potentially be associated with development of IBD include H pylori exposure, helminths, breastfeeding and sibship. However, the vast majority of studies in this area are plagued by serious methodological shortcomings, particularly the reliance on retrospective recall of information making it difficult to truly ascertain the importance of a 'hygiene hypothesis' in IBD. The 'hygiene hypothesis' in IBD is an important area of research that may give clues to the aetiology of this disease. Directions for future research are recommended. | Natasha A Koloski Laurel Bret Graham Radford-Smith | 2008 | World Journal of Gastroenterology2008，14，2： | 16 |
| 2 | The role of endoscopy in the evaluation of suspected choledocholithiasis显示文摘 | John T. Maple Tamir Ben-Menachem Michelle A. Anderson Vasundhara Appalaneni Subhas Banerjee Brooks D. Cash Laurel Fisher M. Edwyn Harrison Robert D. Fanelli Norio Fukami Steven O. Ikenberry Rajeev Jain Khalid Khan Mary Lee Krinsky Laura Strohmeyer Jason A | 2010 | Gastrointestinal Endoscopy2010，，1： | 2 |
| 3 | Enzymatic activity of prostate-specific antigen and its reaction with extracellular serine proteinase inhibitors显示文摘 | Christensson A Laurell CB Lilja H | 1996 | Eur J Biochem1996，194，1： | 1 |
| 4 | Citation Analysis of Education Disserta- tions for Collection Development 显示文摘 | Laurel A Haycock | 2004 | Library Resources & Technical Services2004，，2： | 1 |
| 5 | The SHG-response of different phases in proton exchanged lithium niobate waveguides显示文摘 | KORKISHKO Y N FEEX)ROV V A LAURELL F | 2000 | IEEE Journal of Selected Topics in Quantum Electronics2000，6，1： | 1 |
| 6 | Long-term progressionfree survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell rescue:a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Group显示文摘 | Geisler CH Kolstad A Laurell A | 2008 | Blood2008，112，7： | 1 |
| 7 | Nordic MCL2 trial update:sixyear follow-up after intensive immunochemotherapy for untreated mantle cell lymphoma followed by BEAM or BEAC+autologous stem-cell support:still very long survival but late relapses do occur显示文摘 | Geisler CH Kolstad A Laurell A | 2012 | Haematol2012，158，3： | 1 |
| 8 | Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors显示文摘 | Christensson A Laurell C B Lilja H | 1990 | Eur J Biochem1990，194，3： | 1 |
| 9 | Blood flow independent accumulation of cisplatin in the guinea pig cochlea显示文摘 | Miettinen S Laurell G Andersson A | 1997 | Acta Otolaryngol1997，117，1： | 1 |
| 10 | Characterization of a Novel A Influenza Virus hemagglutinin subtype(H16) obtained from black - headed gulls 显示文摘 | RON A M F VINCENT M LAUREL G | 2005 | Journal of Virology2005，79，5： | 1 |
| 11 | Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome显示文摘 | Tobin G Thunberg U Laurel A | | 0，，04： | 1 |
| 12 | Lodging reduce yield of rice by self-shading and reductions in canopy photosynthesis显示文摘 | Setter T L Laureles E V Mazaredo A M | 1997 | Field Crops Research1997，49，： | 1 |
| 13 | Enzymatic activity of the prostate specific antigen and its reactions with extracellular serine protease inhibitors 显示文摘 | CHRISTENSSON A LAURELL CB LILJA H | 1990 | Eur J Biochem1990，194，： | 1 |
| 14 | α 1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages显示文摘 | Laurel A Grisanti Andrew P Woster Julie Dahlman | 2011 | J Pharmaeol Exp Ther2011，338，2： | 1 |
| 15 | Long-term progres- sinn-free survival of mantle cell lymphoma after intensive front-line immunochemotherapy with in vivo-purged stem cell res- cue: a nonrandomized phase 2 multicenter study by the Nordic Lymphoma Croup显示文摘 | Geisler CH Kolstad A Laurell A | 2008 | Blood2008，112，7： | 1 |
| 16 | Lodging reduces yield of rice by self - shading and reductions in canopy photosyn- thesis显示文摘 | Setter T L Laureles E V Mazaredo A M | 1997 | Field Crop Res1997，49，： | 1 |
| 17 | Ototoxicity, nephrotoxicity and pharmacokinetics of cisplatin and its monohydrated complex in the guinea pig显示文摘 | Ekbom A Lindberg A laurel G | 2003 | Cancer Chemother Pharmacol2003，51，1： | 1 |
| 18 | The Mande Cell Lympho- ma International Prognostic Index (MIPI) is superior to the Interna- tional Prognostic Index (IPI) in predicting survival following inten- sive first-line immunochemotherapy and autologous stem cell trans- plantation (ASCT) 显示文摘 | Geisler CH Kolstad A Laurell A | 2010 | Blood2010，115，8： | 1 |
| 19 | Enzymatic activity of the prostate-specific antigen and its reactions with extracellular serine protease inhibitors 显示文摘 | CHRISTENSSON A LAURELL C B LILJA H | 1990 | Eur J Biochem1990，194，： | 1 |
| 20 | The impact of hyperglycemia on patients with severe brain injury显示文摘 | Elan J Laurel A O Michael D | 2005 | J Trauma2005，58，1： | 1 |
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