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85篇 您的检索式：作者名="LAURENCE T"

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	题名	作者	年代	出处	被引量
1	New synthesis method of a Si nanocomposite anode for Li - ion batteries 显示文摘	Laurence L O Monique T David Z	2008	Chem Mater2008，20，4：	1
2	Interleukin - 2 sig -naling via STAT5 constrains T helper 17 cell generation显示文摘	Laurence A Tato C M Davidson T S	2007	Im- munity2007，26，3：	1
3	Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina显示文摘	Stefan B Laurence T Christoph B	2002	Circulation2002，106，1：	1
4	Interleukin - 2 signaling via STATS constrains T helper 17 cell generation显示文摘	LAURENCE A TATO C M DAVIDSON T S	2007	Immunity2007，26，3：	1
5	Niosomes and Polymeric Chitosan Based Vesicles Bearing Transferrin and Glucose Ligands for Drug Targeting显示文摘	CHRISTINE D ANDREAS G S LAURENCE T	2000	Pharmaceutical Research(S0724-8741)2000，17，10：	1
6	Adhesion molecules and atherosclerosis显示文摘	Stefan B Sandrine B Laurence T	2013	Atherosclemsis2013，170，2：	1
7	Retinoic acid inhibits Thl7 polarization and enhances FoxP3 expression through a Stat -3/Stat -5 independent signaling Pathway 显示文摘	Elias K M Laurence A Davidson T S	2008	Blood2008，111，3：	1
8	TPGF : Geographic routing in wireless multimedia sensor networks 显示文摘	Lei Shu Yan Zhang Yang Laurence T	2010	Telecommunication Systems2010，44，1：	1
9	NF-κB signaling pros and cons of altering NF-κB as a therapeutic approach显示文摘	Laurence J Murat T	2006	Ann N Y Acad Sci2006，1072，：	1
10	Staticarbitrage upper bounds for the prices of basket options 显示文摘	Hobson D Laurence P M Wang T H	2005	Quantitative Finance2005，5，：	1
11	Convergence to steady states for radially symmetric solutions to a qua- silinear degenerate diffusive Hamilton-Jaeobi equation显示文摘	BARLES G LAURENC A)T P STINNER C	2010	Asymptot Anal2010，67，34：	1
12	Patient satisfaction with point-of-care testing in general practice 显示文摘	Laurence CO Gialamas A Bubner T	2010	Br J Gen Pract2010，60，572：	1
13	A systematic review ofa liver-first approach in patients with colorectal cancer andsynchronous colorectal liver metastases 显示文摘	Lam VW Laurence JM Pang T	2014	HPB (Oxford )2014，16，：	1
14	Interleukin-2 signaling via STATS constrains T helper 17 cell generation显示文摘	LAURENCE A TATO C M DAVIDSON T S	2007	Immunity2007，26，：	1
15	An evaluation of three clustering procedures for use in synoptic classification显示文摘	Guanri T Jon A S	1987	American Meteorological Society1987，26，5：	1
16	Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH.	Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet	2022	Bone Research2022，10，1：	1
17	Realistic modeling approaches of structure-function properties of CPPs in non-covalent complexes 显示文摘	Annick T Laurence L Gilles D	2010	Biochimica et Biophysica Acta2010，1798，：	1
18	Single-molecule protein folding:diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor显示文摘	Deniz A A Laurence T A Beligere G S		0，，：	1
19	Metallic-like photoluminescence and absorption in fused silica surface flaws显示文摘	Laurence T A Bude J D Shen N	2009	Applied Physics Letters2009，94，15：	1
20	The effect of viewpoint on perceived visual roughness显示文摘	Yun-Xian Ho Laurence T Maloney	2007	Joumal of Vision2007，7，1：	1

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