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    题名 作者 年代 出处 被引量
1Probiotic bacte- ria as biological control agents in aquaculture:a review显示文摘Lauren V Greert R Patrick S 2000Microbiology and Molecular Biology Reviews2000,64,4:1
2Two new biologi cally active triterpenoidal saponins acylated with salicylic acid from Albizia adianthifolia显示文摘Haddad T Miyamoto Laurens V 2003Nat Prod2003,66,:1
3Neural stem cell adhesion and proliferation on phospholipid bilayers functionalized with RGD peptides 显示文摘Badriprasad Ananthanarayanan Lauren Little David V Schaffer 2010Biomaterials2010,31,:1
4Gas chromatographic-mass spectrometric confirmation of atractyloside in a patient poisoned with Callilepis laureola显示文摘Laurens J B Bekker L C Steenkamp V 2001J Chromatogr B2001,765,2:1
5Optical coherence tomography-guided retinal prosthe- sis design: model of degenerated retinal curvature and thickness for patient-specific devices显示文摘Nicholas L Opie Lauren N Ayton Nicholas V Apollo 2014Health science2014,38,6:1
6Recombinant human angiostatin by twice-daily subcutaneous injection in advanced cancer:a pharmacokinetic and long-term safety study显示文摘LAURENS V BEEREPOOT 2003Clin Cancer Res2003,9,11:1
7Imaging of nitric oxide in a living vertebrate using a diamino-fluoreseein probe 显示文摘Lepiller S Laurens V Bouchot A 2007Free Radic Biol Med2007,43,4:1
8Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments.Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis 2022Stroke & Vascular Neurology2022,7,2:1
9Visualizing data using t-SNE显示文摘Laurens V D Hinton G 0,,:1
10Matrix metalloproteinase inhi- bition protects rat livers from prolonged cold ischemia-warm repcrfu- sion injury显示文摘Defamie V Laurens M Patrono D 2008nepatology2008,47,1:1
11Behavior,capture and initiation of some trace elements during combustion of refuse-derived char from municipal solid waste显示文摘Vassilev S V Braekman - Danheux C Lauren P 1999Fuel1999,,78:1
12Automatic detection of rib borders in chest radiographs显示文摘YUE Zhan-Jun Gohtasby Ardeshir Ackerman Laurens V 1995IEEE Transactions on Medical Imaging1995,14,3:1
13Fuzzy cognitive maps and cellular automata:An evolutionary approach for social systems modeling显示文摘Kumar M V Laurens B Papageorgiou Elpiniki I 2012Applied Soft Computing2012,12,12:1
14Market segmentation and product technology selection for remanufacturable products显示文摘Laurens G D Toktay L B Wassenhove L N V 2005Management Science2005,51,8:1
15Gas chromato-graphic-mass spectrometric confirmation of atractyloside in a pa-tient poisoned with Callilepis laureola显示文摘Laurens J B Bekker L C Steenkamp V 2001J Chromatogr B2001,765,2:1
16The Vh8 lo- cus of a new gene-for-gene interaction between Venturia inae- qualis and the wild apple Malus sieversii is closely linked to the Vh2 locus in Malus pumila R12740 - 7A显示文摘Bus V G Laurens F N van de Weg W E 2005New Phytolo- gist2005,166,3:1
17Nursing schools to teach new ways to cope with death 显示文摘Lauren V 2011CMAJ2011,183,4:1
18Recombinant Human Angiostatin by Twice-Daily Subcutaneous Injection in Advanced Cancer:A Pharmacokinetic and Long-Term Safety Study显示文摘Laurens V Beerepeot 2003Clin Cancer Res2003,9,11:1
19Microalgae as biodiesel & biomass feedstocks:Review & analysis of the biochemistry,energetics & economics显示文摘Williams V J B Laurens L M L 2010Energy Env Sci2010,3,5:1
20Involvement of phenolic compounds in host resistance against Botrytis cinerea in leaves of the two commercially important kiwffruit eultivars显示文摘 GEORGE M P LAUREN D R 2003New Zealand J of Crop and Hort Science2003,31,3:1
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