|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 北京气候中心气候系统模式研发进展——在气候变化研究中的应用显示文摘较全面地介绍了北京气候中心气候系统模式(BCC_CSM)研发所取得的一些进展及其在气候变化研究中的应用,重点介绍了全球近280 km较低分辨率的全球海-陆-气-冰-生物多圈层耦合的气候系统模式BCC_CSM1.1和110 km中等大气分辨率的BCC_CSM1.1(m),以及大气、陆面、海洋、海冰各分量模式的发展。BCC_CSM1.1和BCC_CSM1.1(m)气候系统模式均包含了全球碳循环和动态植被过程。当给定全球人类活动导致的碳源排放后,就可以模拟和预估人类活动对气候变化的影响。BCC_CSM1.1和BCC_CSM1.1(m)已应用于IPCC AR5模式比较,为中外开展气候变化机理分析和未来气候变化预估提供了大量的试验数据。还介绍了BCC_CSM1.1和BCC_CSM1.1(m)参与国际耦合模式比较计划(CMIP5)的大量试验分析评估结果,BCC_CSM能够较好地模拟20世纪气温和降水等气候平均态和季节变化特征,以及近1000年的历史气候变化,所预估的未来100年气候变化与国际上其他模式的CMIP5试验预估结果相当。初步的分析表明,分辨率相对高的BCC_CSM1.1(m)在区域气候平均态的模拟上优于分辨率较低的BCC_CSM1.1。 | 吴统文 宋连春 李伟平 王在志 张华 辛晓歌 张艳武 张莉 李江龙 吴方华 刘一鸣 张芳 史学丽 储敏 张洁 房永杰 汪方 路屹雄 刘向文 魏敏 刘茜霞 周文艳 董敏 赵其庚 季劲钧 Laurent Li 周明煜 | 2014 | 气象学报2014，72，1： | 44 |
| 2 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 3 | An Overview of BCC Climate System Model Development and Application for Climate Change Studies显示文摘This paper reviews recent progress in the development of the Beijing Climate Center Climate System Model(BCC-CSM) and its four component models(atmosphere,land surface,ocean,and sea ice).Two recent versions are described:BCC-CSM1.1 with coarse resolution(approximately 2.8125°×2.8125°) and BCC-CSM1.1(m) with moderate resolution(approximately 1.125°×1.125°).Both versions are fully coupled climate-carbon cycle models that simulate the global terrestrial and oceanic carbon cycles and include dynamic vegetation.Both models well simulate the concentration and temporal evolution of atmospheric CO_2 during the 20th century with anthropogenic CO2 emissions prescribed.Simulations using these two versions of the BCC-CSM model have been contributed to the Coupled Model Intercomparison Project phase five(CMIP5) in support of the Intergovernmental Panel on Climate Change(IPCC) Fifth Assessment Report(AR5).These simulations are available for use by both national and international communities for investigating global climate change and for future climate projections.Simulations of the 20th century climate using BCC-CSMl.l and BCC-CSMl.l(m) are presented and validated,with particular focus on the spatial pattern and seasonal evolution of precipitation and surface air temperature on global and continental scales.Simulations of climate during the last millennium and projections of climate change during the next century are also presented and discussed.Both BCC-CSMl.l and BCC-CSMl.l(m) perform well when compared with other CMIP5 models.Preliminary analyses indicate that the higher resolution in BCC-CSM1.1(m) improves the simulation of mean climate relative to BCC-CSMl.l,particularly on regional scales. | 吴统文 宋连春 李伟平 王在志 张华 辛晓歌 张艳武 张莉 李江龙 吴方华 刘一鸣 张芳 史学丽 储敏 张洁 房永杰 汪方 路屹雄 刘向文 魏敏 刘茜霞 周文艳 董敏 赵其庚 季劲钧 Laurent LI 周明煜 | 2014 | Journal of Meteorological Research2014，28，1： | 32 |
| 4 | Recent advances in cytokines:Therapeutic implications for inflammatory bowel diseases显示文摘Inflammatory bowel diseases(IBDs) are complex and chronic disabling conditions resulting from a dysregulated dialogue between intestinal microbiota and components of both the innate and adaptive immune systems.Cytokines are essential mediators between activated immune and non-immune cells,including epithelial and mesenchymal cells.They are immunomodulatory peptides released by numerous cells and these have significant effects on immune function leading to the differentiation and survival of T cells.The physiology of IBD is becoming a very attractive field of research for development of new therapeutic agents.These include cytokines involved in intestinal immune inflammation.This review will focus on mechanisms of action of cytokines involved in IBD and new therapeutic opportunities for these diseases. | Guillaume Bouguen Jean-Baptiste Chevaux Laurent Peyrin-Biroulet | 2011 | World Journal of Gastroenterology2011，17，5： | 27 |
| 5 | Does CMIP6 Inspire More Confidence in Simulating Climate Extremes over China?显示文摘Based on climate extreme indices calculated from a high-resolution daily observational dataset in China during 1961–2005,the performance of 12 climate models from phase 6 of the Coupled Model Intercomparison Project(CMIP6),and 30 models from phase 5 of CMIP(CMIP5),are assessed in terms of spatial distribution and interannual variability.The CMIP6 multi-model ensemble mean(CMIP6-MME)can simulate well the spatial pattern of annual mean temperature,maximum daily maximum temperature,and minimum daily minimum temperature.However,CMIP6-MME has difficulties in reproducing cold nights and warm days,and has large cold biases over the Tibetan Plateau.Its performance in simulating extreme precipitation indices is generally lower than in simulating temperature indices.Compared to CMIP5,CMIP6 models show improvements in the simulation of climate indices over China.This is particularly true for precipitation indices for both the climatological pattern and the interannual variation,except for the consecutive dry days.The arealmean bias for total precipitation has been reduced from 127%(CMIP5-MME)to 79%(CMIP6-MME).The most striking feature is that the dry biases in southern China,very persistent and general in CMIP5-MME,are largely reduced in CMIP6-MME.Stronger ascent together with more abundant moisture can explain this reduction in dry biases.Wet biases for total precipitation,heavy precipitation,and precipitation intensity in the eastern Tibetan Plateau are still present in CMIP6-MME,but smaller,compared to CMIP5-MME. | Huanhuan ZHU Zhihong JIANG Juan LI Wei LI Cenxiao SUN and Laurent LI | 2020 | Advances in Atmospheric Sciences2020，37，10： | 27 |
| 6 | Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock显示文摘The mixed venous-to-arterial carbon dioxide(CO_2)tension difference[P(v-a) CO_2]is the difference between carbon dioxide tension(PCO_2) in mixed venous blood(sampled from a pulmonary artery catheter) and the PCO_2 in arterial blood.P(v-a) CO_2 depends on the cardiac output and the global CO_2 production,and on the complex relationship between PCO_2 and CO_2 content.Experimental and clinical studies support the evidence that P(v-a) CO_2 cannot serve as an indicator of tissue hypoxia,and should be regarded as an indicator of the adequacy of venous blood to wash out the total CO_2generated by the peripheral tissues.P(v-a) CO_2 can be replaced by the central venous-to-arterial CO_2 difference(△PCO_2),which is calculated from simultaneous sampling of central venous blood from a central vein catheter and arterial blood and,therefore,more easy to obtain at the bedside.Determining the △PCO_2 during the resuscitation of septic shock patients might be useful when deciding when to continue resuscitation despite a central venous oxygen saturation(SCVO_2) > 70%associated with elevated blood lactate levels.Because high blood lactate levels is not a discriminatory factor in determining the source of that stress,an increased △PCO_2(> 6 mmHg)could be used to identify patients who still remain inadequately resuscitated.Monitoring the △PCO_2 from the beginning of the reanimation of septic shock patients might be a valuable means to evaluate the adequacy of cardiac output in tissue perfusion and,thus,guiding the therapy.In this respect,it can aid to titrate inotropes to adjust oxygen delivery to CO_2 production,or to choose between hemoglobin correction or fluid/inotrope infusion in patients with a too low ScvO_2 related to metabolic demand.The combination of P(v-a) CO_2 or △PCO_2 with oxygen-derived parameters through the calculation of the P(v-a) CO_2 or △PCO_2/arteriovenous oxygen content difference ratio can detect the presence of global anaerobic metabolism. | Jihad Mallat Malcolm Lemyze Laurent Tronchon Beno?t Vallet Didier Thevenin | 2016 | World Journal of Critical Care Medicine2016，5，1： | 25 |
| 7 | Additional risk in extreme precipitation in China from 1.5℃to 2.0℃global warming levels显示文摘To avoid dangerous climate change impact, the Paris Agreement sets out two ambitious goals: to limit the global warming to be well below 2 ℃ and to pursue effort for the global warming to be below 1.5 ℃ above the pre-industrial level. As climate change risks may be region-dependent, changes in magnitude and probability of extreme precipitation over China are investigated under those two global warming levels based on simulations from the Coupled Model Inter-Comparison Projects Phase 5. The focus is on the added changes due to the additional half a degree warming from 1.5 ℃ to 2 ℃ . Results show that regional average changes in the magnitude do not depend on the return periods with a relative increase around 7% and 11% at the 1.5 ℃ and 2 ℃ global warming levels, respectively. The additional half a degree global warming adds an additional increase in the magnitude by nearly 4%. The regional average changes in term of occurrence probabilities show dependence on the return periods, with rarer events(longer return periods) having larger increase of risk. For the 100-year historical event, the probability is projected to increase by a factor of 1.6 and 2.4 at the 1.5 ℃ and 2 ℃ global warming levels, respectively.The projected changes in extreme precipitation are independent of the RCP scenarios. | Wei Li Zhihong Jiang Xuebin Zhang Laurent Li Ying Sun | 2018 | Science Bulletin2018，63，4： | 24 |
| 8 | Changes in temperature extremes over China under 1.5 ℃ and 2 ℃ global warming targets显示文摘 | SHI Chen JIANG Zhi-Hong CHEN Wei-Lin Laurent LI | 2018 | Advances in Climate Change Research2018，9，2： | 22 |
| 9 | Large balloon dilation post endoscopic sphincterotomy in removal of difficult common bile duct stones:A literature review显示文摘Endoscopic sphincterotomy(ES)is the standard therapy in common bile duct(CBD)stones extraction.Large stones(≥12 mm)or multiple stones extraction may be challenging after ES alone.Endoscopic sphincterotomy followed by large balloon dilation(ESLBD)has been described as an alternative to ES in these indications.Efficacy,safety,cost-effectiveness and technical aspects of the procedure have been here reviewed.PubMed and Google Scholar search resulted in fortyone articles dealing with CBD stone extraction with12 mm or more dilation balloons after ES.ESLBD is at least as effective as ES,and reduces the need for additional mechanical lithotripsy.Adverse events rates are not statistically different after ESLBD compared to ES for pancreatitis,bleeding and perforation.However,particular attention should be paid in patients with CBD strictures,which is identified as a risk factor of perforation.ESLBD is slightly cost-effective compared to ES.A small sphincterotomy is usually performed,and may reduce bleeding rates compared to full sphincterotomy.Dilation is performed with 12-20 mm enteral balloons.Optimal inflation time is yet to be determined.The procedure can be performed safely even in patients with peri-ampullary diverticula and surgically altered anatomy.ESLBD is effective and safe in the removal of large CBD stones,however,small sphincterotomy might be preferred and CBD strictures should be considered as a relative contraindication. | Olivier Rouquette Gilles Bommelaer Armo Abergel Laurent Poincloux | 2014 | World Journal of Gastroenterology2014，20，24： | 17 |
| 10 | 2型糖尿病患者服用吡格列酮的膀胱癌风险显示文摘背景
吡格列酮是一种有争议的噻唑烷二酮类口服降糖药物,可以有效降低糖化血红蛋白(HbA1c)浓度,且降低心血管事件的发生风险,但同时也与体重增加和充血性心力衰竭风险的增加有关。尽管目前数据有限,但还是有证据显示它可能还与膀胱癌患病风险的增加有关。 | Laurent Azoulay assistant professor Hui Yin statistician Kristian B Filion assistant professor Jonathan Assayag graduate student 王子贤(编译) | 2012 | 中国处方药2012，10，5： | 17 |
| 11 | Bifidobacterium lactis attenuates onset of inflammation in a murine model of colitis显示文摘AIM: To assess the anti-inflammatory effect of the probiotic Bifidobacterium lactis (B. lactis) in an adoptive transfer model of colitis. METHODS: Donor and recipient mice received either B. lactis or bacterial culture medium as control (deMan Rogosa Sharpe) in drinking water for one week prior to transfer of a mix of naive and regulatory T cells until sacrifice. RESULTS: All recipient mice developed signs of colonic inflammation, but a significant reduction of weight loss was observed in B. lactis-fed recipient mice compared to control mice. Moreover, a trend toward a diminution of mucosal thickness and attenuated epithelial damage was revealed. Colonic expression of pro-inflammatory and T cell markers was significantly reduced in B. lactis-fed recipient mice compared to controls. Concomitantly, forkhead box protein 3, a marker of regulatory T cells, was significantly up-regulated by B. lactis. CONCLUSION: Daily oral administration of B. lactis was able to reduce inflammatory and T cells mediators and to promote regulatory T cells specific markers in a mouse model of colitis. | David Philippe Laurent Favre Francis Foata Oskar Adolfsson Genevieve Perruisseau-Carrier Karine Vidal Gloria Reuteler Johanna Dayer-Schneider Christoph Mueller Stéphanie Blum | 2011 | World Journal of Gastroenterology2011，17，4： | 12 |
| 12 | Aerosol Optical Properties and Its Radiative Forcing over Yulin, China in 2001 and 2002显示文摘The aerosol optical properties and direct radiative forcing over the Mu Us desert of northern China, acquired through a CE318 sunphotometer of the ground-based Aerosol Robotic Network (AERONET), are analyzed. The seasonal variations in the aerosol optical properties are examined. The effect of meteorological elements (pressure, temperature, water vapor pressure, relative humidity and wind speed) on the aerosol optical properties is also studied. Then, the sources and optical properties under two different cases, a dust event and a pollution event, are compared. The results show that the high aerosol optical depth (AOD) found in Yulin was mostly attributed to the occurrence of dust events in spring from the Mu Us desert and deserts of West China and Mongolia, as well as the impacts of anthropogenic pollutant particles from the middle part of China in the other seasons. The seasonal variation and the probability distribution of the radiative forcing and the radiative forcing effciency at the surface and the top of the atmosphere are analyzed and regressed using the linear and Gaussian regression methods. | 车慧正 张小曳 Stephane ALFRARO Bernadette CHATENET Laurent GOMES 赵剑琦 | 2009 | Advances in Atmospheric Sciences2009，26，3： | 11 |
| 13 | Risk of Colorectal Cancer in Patients With Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies显示文摘 | Tine Jess Christine Rungoe Laurent Peyrin–Biroulet | 2012 | Clinical Gastroenterology and Hepatology2012，，6： | 11 |
| 14 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Definitions and diagnosis显示文摘 | Gert Van Assche Axel Dignass Julian Panes Laurent Beaugerie John Karagiannis Mathieu Allez Thomas Ochsenkühn Tim Orchard Gerhard Rogler Edouard Louis Limas Kupcinskas Gerassimos Mantzaris Simon Travis Eduard Stange | 2009 | Journal of Crohn’s and Colitis2009，，1： | 10 |
| 15 | Disease activity and cancer risk in inflammatory bowel disease associated with primary sclerosing cholangitis显示文摘AIM: To investigate the phenotype of inflammatory bowel disease associated with primary sclerosing cholangitis (PSC-IBD). METHODS: Data from 75 PSC-IBD patients evaluated in our tertiary center between 1963 and 2006 were collected and compared to 150 IBD patients without PSC, matched for sex, birth date, IBD diagnosis date and initial disease location regarding ileal, different colonic segments, and rectum, respectively. RESULTS: While PSC-IBD patients received more 5-aminosalicylates (8.7 years/patient vs 2.9 years/ patient, P < 0.001), they required less immuno-suppressors (24% vs 46% at 10 years; P < 0.001) and less intestinal resection (10% vs 44% at 10 years, P < 0.001). The 25-year cumulative rate of colectomy was 25.1% in PSC-IBD and 37.3% in controls (P = 0.004). The 25-year cumulative rate of colorectal cancer was 23.4% in PSC-IBD vs 0% in controls (P = 0.002). PSC was the only independent risk factor for the development of colorectal cancer (OR = 10.8; 95% CI, 3.7-31.3). Overall survival rate without liver transplantation was reduced in PSC-IBD patients (67% vs 91% in controls at 25 years, P = 0.001).CONCLUSION: This study confirms that patients with PSC-IBD have a particular disease phenotype independent of the initial disease location. Although their disease is less active and they use more 5-aminosalicylates, they present a higher risk of colorectal cancer. | Harry Sokol Jacques Cosnes Olivier Chazouilleres Laurent Beaugerie Emmanuel Tiret Raoul Poupon Philippe Seksik | 2008 | World Journal of Gastroenterology2008，14，22： | 10 |
| 16 | 单一端元岩浆流体的减压沸腾作用是钨-锡矿形成的一种重要机制显示文摘全球范围内的锡(Sn)和钨(W)矿化普遍与高演化花岗岩有关,但是达到经济品位的矿床较少,且矿化的类型也各有不同,其矿床成因机制一直存在较大争议。近日,《地质学》杂志报道了德国地球科学研究中心的Maximilian Korges等人关于上述问题的研究成果。该团队以位于德国和捷克的Erzgebirge山脉的ZinnwaldS n-W矿床为研究对象,进行了系统的流体包裹体地球化学研究。 | Maximilian Korges Philipp Weis Volker Lüders Oscar Laurent 袁超 | 2018 | 矿物岩石地球化学通报2018，37，2： | 10 |
| 17 | Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial显示文摘 | Axel Grothey Eric Van Cutsem Alberto Sobrero Salvatore Siena Alfredo Falcone Marc Ychou Yves Humblet Olivier Bouché Laurent Mineur Carlo Barone Antoine Adenis Josep Tabernero Takayuki Yoshino Heinz-Josef Lenz Richard M Goldberg Daniel J Sargent Frank Ciho | 2012 | The Lancet2012，，： | 10 |
| 18 | 蘑菇子实体内杀虫蛋白质的研究(英文)显示文摘许多蘑菇都对昆虫表现出毒性。为了证实与杀虫毒性有关的化合物 ,对 14种蘑菇的毒性在水溶性、热敏性和可透析性等方面进行了研究。研究数据表明 ,蛋白质对大多数蘑菇子实体的杀虫活性起着重要作用 ,也许是一种可以用于植物抵抗害虫的基因源。在数种蛋白质中 ,凝集素和溶血素因不受蛋白酶的影响而成为良好的杀虫剂候选材料。 | 王鸣 Verorique Triguercs Laurent Paquereau Louis Chavant Didier Fournier | 2002 | 云南植物研究2002，24，2： | 10 |
| 19 | Interplay between Kitaev interaction and single ion anisotropy in ferromagnetic CrI_(3) and CrGeTe_(3) monolayers显示文摘Magnetic anisotropy is crucially important for the stabilization of two-dimensional(2D)magnetism,which is rare in nature but highly desirable in spintronics and for advancing fundamental knowledge.Recent works on CrI3 and CrGeTe_(3) monolayers not only led to observations of the long-time-sought 2D ferromagnetism,but also revealed distinct magnetic anisotropy in the two systems,namely Ising behavior for CrI3 versus Heisenberg behavior for CrGeTe_(3).Such magnetic difference strongly contrasts with structural and electronic similarities of these two materials,and understanding it at a microscopic scale should be of large benefits.Here,firstprinciples calculations are performed and analyzed to develop a simple Hamiltonian,to investigate magnetic anisotropy of CrI3 and CrGeTe_(3) monolayers.The anisotropic exchange coupling in both systems is surprisingly determined to be of Kitaev-type.Moreover,the interplay between this Kitaev interaction and single ion anisotropy(SIA)is found to naturally explain the different magnetic behaviors of CrI3 and CrGeTe_(3).Finally,both the Kitaev interaction and SIA are further found to be induced by spin–orbit coupling of the heavy ligands(I of CrI3 or Te of CrGeTe_(3))rather than the commonly believed 3d magnetic Cr ions. | Changsong Xu Junsheng Feng Hongjun Xiang Laurent Bellaiche | 2018 | npj Computational Materials2018，，1： | 10 |
| 20 | Modeling of wireless SAW temperature sensor and associated antenna显示文摘Surface acoustic wave(SAW)resonator used as wireless sensor was characterized and the parameters of its MBVD(Modified Butterworth-Van Dyke)model were extracted versus temperature.The extracted parameters lead toevaluate the resonator performancesin terms of Temperature coefficient of frequency(TCF)and quality factor(Q).An antenna was then associated with the SAW resonator and the entire system has been characterized and modeled.The good agreement experiment-simulation allows to define the optimum operating conditions of the wireless sensor. | Laurent ALLIES Eloi BLAMPAIN Hamid M'JAHED Gerard PRIEUR Omar ELMAZRIA | 2014 | Instrumentation2014，1，1： | 10 |
您所在的机构暂未开通此部分的功能，请联系管理员