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您的检索式：作者名="LE X Chris"
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| 1 | HPLC-DRC-ICP-MS检测四种尿砷化合物显示文摘拟建立检测尿液中As(Ⅲ)、DMA(Ⅴ)、MMA(Ⅴ)和As(Ⅴ)4种砷化合物形态的HPLC—DRC-ICP—MS的方法。采用DRCTM(反应气为O2)与HPLC联用作为检测器,Phenomenex ODS-3作为分离柱,5 mmol/L四丁基羟胺,3 mmol/L丙二酸,5%(体积分数)甲醇为流动相(pH=5.0~6.0),建立了同时分析尿液中As(Ⅲ)、DMA(Ⅴ)、MMA(Ⅴ)和As(Ⅴ)的方法。实验结果显示:该分析方法对上述4种砷化合物的检测限均在0.1μg/L以下,在1~20μg/L范围内线性关系良好,准确度和精密度良好,回收率为89%~106%,样品中的Cl^-1对测定没有影响。所建立的HPLC-DRC-ICP—MS分析方法稳定、可靠,适用于快速、批量测定尿砷形态。 | 邓国栋 郑宝山 王学 李社红 王明国 李波 胡军 Xiufen LU X Chris Le | 2008 | 地球与环境2008，36，3： | 2 |
| 2 | Inhibition of nucleotide excision repair by arsenic显示文摘Inhibition of DNA repair is one proposed mechanism for the co-mutagenicity/co-carcinogenicity of arsenic.This review summarizes the current literature on the effects of arsenic compounds on nucleotide excision repair(NER).Several possible mechanisms for the observed NER inhibition have been proposed.Modulation of the expression of NER proteins has been considered to be one possibility of impairing the NER process.However,data on the effects of arsenic on the expression of NER proteins remain inconsistent.It is more likely that arsenic inhibits the induction of accessory or other key proteins involved in cellular control of DNA repair pathways,such as p53.For example,arsenic affects p53 phosphorylation and p53 DNA binding activity,which could regulate NER through transcriptional activation of downstream NER genes.Although it is important to study possible direct inactivation of NER proteins by arsenic binding,indirect inactivation of proteins having thiol residues critical to their function or zinc finger proteins cannot be negated.For example,nitric oxide(NO) induced in arsenic-treated cells serves as a specific inhibitor of NER,possibly through NO-induced S-nitrosylation of proteins related to DNA repair.Poly(ADP-ribose) polymerase-1,a zinc finger protein implicated in both NER and base excision repair(BER),deserves special attention because of its involvement in NO production and its broad range of protein substrates including many repair enzymes. | SHEN Shengwen WANG Chuan WEINFELD Michael LE X Chris | 2013 | Chinese Science Bulletin2013，58，2： | 1 |
| 3 | Effect of arsenosugar ingestion on urinary arsenic spectiation显示文摘 | Mingsheng Ma and X Chris Le | 1998 | Clinical Chemistry1998，44，： | 1 |
| 4 | Aptamer-Modified Monolithic Capillary Chromatography for Protein Separation and Detection 显示文摘 | Zhao Qiang Xing Fang Li X Chris Le | 2008 | Anal Chem2008，80，10： | 1 |
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