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您的检索式：作者名="WEINFELD Michael"
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| 1 | Inhibition of nucleotide excision repair by arsenic显示文摘Inhibition of DNA repair is one proposed mechanism for the co-mutagenicity/co-carcinogenicity of arsenic.This review summarizes the current literature on the effects of arsenic compounds on nucleotide excision repair(NER).Several possible mechanisms for the observed NER inhibition have been proposed.Modulation of the expression of NER proteins has been considered to be one possibility of impairing the NER process.However,data on the effects of arsenic on the expression of NER proteins remain inconsistent.It is more likely that arsenic inhibits the induction of accessory or other key proteins involved in cellular control of DNA repair pathways,such as p53.For example,arsenic affects p53 phosphorylation and p53 DNA binding activity,which could regulate NER through transcriptional activation of downstream NER genes.Although it is important to study possible direct inactivation of NER proteins by arsenic binding,indirect inactivation of proteins having thiol residues critical to their function or zinc finger proteins cannot be negated.For example,nitric oxide(NO) induced in arsenic-treated cells serves as a specific inhibitor of NER,possibly through NO-induced S-nitrosylation of proteins related to DNA repair.Poly(ADP-ribose) polymerase-1,a zinc finger protein implicated in both NER and base excision repair(BER),deserves special attention because of its involvement in NO production and its broad range of protein substrates including many repair enzymes. | SHEN Shengwen WANG Chuan WEINFELD Michael LE X Chris | 2013 | Chinese Science Bulletin2013，58，2： | 1 |
| 2 | Palmitic Acid -Modified Poly-L-Lysinc for Non-Viral Delivery of Plasmid DNA to Skin Fibroblasts显示文摘 | Meysam Abbasi Hasan Uludag Vanessa lncani Cori Olson Xiaoyue Lin Bastiak Aetian Clements Dorothy Rutkowski Aziz Ghahary Michael Weinfeld | 2007 | Biomacromolecules2007，8，4： | 1 |
| 3 | 砷对核苷酸切除修复的抑制显示文摘砷对DNA修复的抑制被认为是其产生共致突变作用/共致癌作用的一种途径.本文综述了有关砷化合物影响核苷酸切除修复(NER)的报道.对于核苷酸切除修复是如何被砷抑制的,目前已有好几种推测机制. | 沈胜文 王川 Michael Weinfeld 乐晓春 | 2012 | 科学通报2012，57，33： | 0 |
| 4 | 格莱美发掘小鸡!显示文摘颁奖嘉宾:格莱美年度最佳专辑获奖者是……“南方小鸡”。记者:“南方小鸡”赢得了五个格莱美提名的全部奖项,包括年度最佳专辑、年度最佳唱片、年度最佳单曲以及其它两个奖项。她们在批评布什总统之后深受影响。 | Michael Weinfeld 凯文 | 2007 | 疯狂英语(初中天地)2007，，5： | 0 |
| 5 | XRCC1磷酸化增强核酸单链断裂修复中聚核苷酸激酶的活性显示文摘生物体长期暴露于离子辐射可诱导一系列核酸损伤。如果这些损伤不能得以及时修复,可导致基因变异、诱发癌症的产生。人类X射线损伤修复交叉互补蛋白1(XRCC1) | 吕美玲 汪海林 Michael Weinfeld | 2009 | 生物物理学报2009，0，S1： | 0 |
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