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| 1 | 缺血性脑卒中和出血性脑卒中患者发病前后血压的变化显示文摘《中国高血压防治指南2010》指出,急性脑卒中的血压处理缺乏足够的临床试验证据,参考建议如下:急性脑卒中溶栓前血压应控制在<185/110mm Hg(1mm Hg=0.133kPa)。对急性缺血性脑卒中发病24h内血压升高的患者应谨慎处理,收缩压≥180mm Hg或舒张压≥100mm Hg或伴有严重心功能不全、主动脉夹层、高血压脑病者,一般不予降压。降压的合理目标是24h内血压降低约15%。有高血压病史且正在服用降压药物者,如神经功能平稳,可于脑卒中发病后24h开始使用降压药物。因此,了解脑卒中患者发病前后的血压情况对临床治疗有重要的意义。Fischer等研究者探讨缺血性脑卒中和出血性脑卒中患者发病前后血压的变化情况。结果表明,缺血性脑卒中患者发病后首次测量的收缩压低于出血性脑卒中。与发病前比较,缺血性脑卒中发病后收缩压略升高(约10.6mm Hg),24h内轻度降低(约13.6mm Hg);而出血性脑卒中发病后,收缩压明显升高(约40.7mm Hg),24h内明显下降(约41.1mm Hg)。出血性脑卒中发病前几天及几周的平均收缩压逐渐增加,而缺血性脑卒中无明显变化。出血性脑卒中患者发病3h内的最高收缩压比发病前高50.0 mm Hg,而缺血性脑卒中则低5.2mm Hg。综上所述,与发病前比较,出血性脑卒中发病后收缩压升高,而缺血性脑卒中无明显变化。 | Fischer U Cooney MT Bull LM Silver LE Chalmers J Anderson CS Mehta Z Rothwell PM 林东杰 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 13 |
| 2 | Comparison of two remote sensing models for estimating evapotranspiration: algorithm evaluation and application in seasonally arid ecosystems in South Africa显示文摘Remote sensing tools are becoming increasingly important for providing spatial information on water use by different ecosystems. Despite significant advances in remote sensing based evapotranspiration(ET) models in recent years, important information gaps still exist on the accuracy of the models particularly in arid and semi-arid environments. In this study, we evaluated the Penman-Monteith based MOD16 and the modified Priestley-Taylor(PT-JPL) models at the daily time step against three measured ET datasets. We used data from two summer and one winter rainfall sites in South Africa. One site was dominated by native broad leaf and the other by fine leafed deciduous savanna tree species and C4 grasses. The third site was in the winter rainfall Cape region and had shrubby fynbos vegetation. Actual ET was measured using open-path eddy covariance systems at the summer rainfall sites while a surface energy balance system utilizing the large aperture boundary layer scintillometer was used in the Cape. Model performance varied between sites and between years with the worst estimates(R2<0.50 and RMSE>0.80 mm/d) observed during years with prolonged mid-summer dry spells in the summer rainfall areas. Sensitivity tests on MOD16 showed that the leaf area index, surface conductance and radiation budget parameters had the largest effect on simulated ET. MOD16 ET predictions were improved by:(1) reformulating the emissivity expressions in the net radiation equation;(2) incorporating representative surface conductance values;and(3) including a soil moisture stress function in the transpiration sub-model. Implementing these changes increased the accuracy of MOD16 daily ET predictions at all sites. However, similar adjustments to the PT-JPL model yielded minimal improvements. We conclude that the MOD16 ET model has the potential to accurately predict water use in arid environments provided soil water stress and accurate biome-specific parameters are incorporated. | Sebinasi DZIKITI Nebo Z JOVANOVIC Richard DH BUGAN Abel RAMOELO Nobuhle P MAJOZI Alecia NICKLESS Moses A CHO David C LE MAITRE Zanele NTSHIDI Harrison H PIENAAR | 2019 | Journal of Arid Land2019，11，4： | 4 |
| 3 | 神经病理性疼痛的新机制:脊髓背角氯离子失衡导致5-HT下行抑制作用转变为易化作用显示文摘急性痛对机体具有保护作用。过度疼痛激活内源性镇痛系统,从而有效控制疼痛。内源性痛觉调制系统如何参与神经病理性疼痛,近年来备受关注。法国波尔多大学的研究者发现:神经损伤引起脊髓背角氯离子失衡,导致内源性5-HT系统由下行抑制转变为下行易化,进而诱导神经病理性疼痛。第一部分研究主要在正常小鼠上进行,发现RMg的5-HT能神经元投射到脊髓背角,产生内源性镇痛作用(既发挥下行抑制的作用)。 | 刘风雨(译) Aby F Lorenzo LE Grivet Z | 2022 | 中国疼痛医学杂志2022，28，9： | 2 |
| 4 | Caspase activation and neuroprotection in caspase-3 deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation 显示文摘 | Le D Wu Y Huang Z | 2002 | Proc Natl Acad Sci2002，99，15： | 1 |
| 5 | Characterization and comparative profiling of the smallRNA transcriptomes in two phases of locust显示文摘 | Wei Y Y Chen S Yang P C Ma Z Y Le K | 2009 | Genome Bilogy2009，10，： | 1 |
| 6 | Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites显示文摘 | Guan X Wang LE Liu Z | 2013 | J Cell Mol Med2013，17，7： | 1 |
| 7 | Cloning and expression of five heat shock protein genes in relation to cold hardening and development in the leafminer, Liriomyza sativa 显示文摘 | Huang L H Wang C Z Le K | 2009 | Journal of lnsect Physiology2009，55，： | 1 |
| 8 | 显示文摘 | Le Baron PC Wang Z Pinnavaia T | 1999 | J Appl Clay Sci1999，15，12： | 1 |
| 9 | Interleukin-18/interleukin-18 binding protein signaling modulates ischemia-in duced neovascularization in mice hind limb显示文摘 | Silvestre JS Le Ricousse-Roussanne S | 2002 | Cire Res2002，91，5： | 1 |
| 10 | p53 transgenic mice are highly susceptible to 1, 2- dimethylhydrazine-induced uterine sarcomas 显示文摘 | Zhang Z Li J Lantry LE | 2002 | Cancer Res2002，62，11： | 1 |
| 11 | Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome显示文摘 | LE L Q KABAROWSKI J H WENG Z | 2001 | Immunity2001，14，5： | 1 |
| 12 | Support for product data from design to production显示文摘 | KOVACS Z LE GOFF J-M MC Clatchey R | 1998 | Computer Integrated Manufacturing Systems1998，11，4： | 1 |
| 13 | Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum显示文摘 | Le Saux O Urban Z Tschuch C | 2000 | Nat Genet2000，25，1： | 1 |
| 14 | Antipsychotic drugs cause glial cell line-derived neurotrophic factor secretion from (;6 glioma cells 显示文摘 | Shao Z Dyck LE Wang H | 2006 | J Psychiatry Neurosci2006，31，： | 1 |
| 15 | Spectroscopic, stability and antioxidant properties of a novel pigment from Gardenia显示文摘 | Yang C Le C Can Z | 2008 | Food Chemistry2008，109，： | 1 |
| 16 | Evolution of trypsinogen activation peptides显示文摘 | Chen J M Kukor Z Le Marechal C | 2003 | Mol Biol Evol2003，，20： | 1 |
| 17 | Measurement and rectification of PCB image errors显示文摘 | Zhu H Xu Z H Le J | 2002 | Preliminary Program of ISIST''2002，，4： | 1 |
| 18 | Glomus tumor of the nail area显示文摘 | Foucher C Le Viet Dailiana Z | 1999 | Rew Chit Orthop Reparatrice Appor Mot1999，85，4： | 1 |
| 19 | Preparation of nano-copper oxide modified glassy carbon electrode by a novel film plating/potential cycling method and its characterization 显示文摘 | Le W Z Liu Y Q | 2009 | Sensors and Actuators B: Chemical2009，141，1： | 1 |
| 20 | Anti-apoptotic role of caspase-eleaved GAB1 adaptor protein in hepatocyte growth factor/scatter factor-MET receptor protein signaling显示文摘 | LE GOFF A JI Z LECLERCQB | 2012 | J Biol Chem2012，287，35： | 1 |
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