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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | The bifunctional x-amylase/subtilisin inhibitor of barley: nucleotide sequence and patterns of seed-specific ex- pression 显示文摘 | Leah R Mundy J | 1989 | Plant Mol Bio1989，12，6： | 1 |
| 3 | Modelling of cells,stacks and sustems based around metal-supported planar IT-SOFC cells with CGO eletrolytes operating at 500~600℃显示文摘 | Leah R T BrTandon N P Aguiar P | | 0，，： | 1 |
| 4 | Development of highly robust,volume manufacturable metal-supported sofcs for operation be-low 600℃显示文摘 | Leah R Selcuk A Corcoran D | | 0，，01： | 1 |
| 5 | Modelling of cells,stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 500 ~ 600 ℃显示文摘 | LEAH R T BRANDON N P AGUIAR P | 2005 | Power Sources2005，145，2： | 1 |
| 6 | Identification of a methyl jasmonate-responsive region in the promoter of a lipoxygenase 1 gene expressed in barley grain显示文摘 | Rouster J Leah R Mundy J Cameron-Mills | | 0，，03： | 1 |
| 7 | Identification of a methyl jasmonate-responsive region in the promoter of a lipoxygenase 1 gene expressed in barley grain显示文摘 | ROUSTER J LEAH R MUNDY J | 1997 | The Plant Journal1997，11，3： | 1 |
| 8 | Modeling of ceils, stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 500-600显示文摘 | Leah R T Brandon N P Aguiar P | 2005 | Journal of Power Sources2005，145，2： | 1 |
| 9 | Biochemical and molecular characterization of three barley seed protein with antifungal properties显示文摘 | LEAH R TOMMERUP H SVENDSEN I | 1991 | Y Bid Chem1991，266，： | 1 |
| 10 | Identifieation of a methyljasmonate -responsive region in the promoter of a lipoxygenase1 gene expressed in barley grain显示文摘 | Rouster J Leah R Mundy J | 1997 | Plant J1997，11，3： | 1 |
| 11 | Identification of a methyl jasmonate-responsive region in the promoter of a lipoxygenase 1 gene expressed in barley grain 显示文摘 | Rouster J Leah R Mundy J | 1997 | The Plant Journal1997，11，3： | 1 |
| 12 | Identification of a methyl jasmonate - responsive region in the promoter of a lipoxygenase 1 gene expressed in barley grain 显示文摘 | Rouster J Leah R Mundy J V | 1997 | Plant J1997，11，3： | 1 |
| 13 | Distributed intelligent architecture for logistics (DIAL) 显示文摘 | Goutam Satapathy Kumara Soundar R T Leah M Moore | 1998 | Expert Systems With Applications1998，14，4： | 1 |
| 14 | Accuracy of neural network approximator in simulation-optimization显示文摘 | Virginia M J Leah L R | 2000 | Journal of Water Resources Planning and Management ASCE2000，126，2： | 1 |
| 15 | Association between elevated activity of aryl aeylamidase and propanil resistance in jungle-rice, Echinochloa colona 显示文摘 | Leah J M Caseley J C Riches C R | 1994 | Pesticide Science1994，42，4： | 1 |
| 16 | The bifunctional c-amylase/ subtilisin inhibitor of barley: nucleotide sequence and patterns of seed-specific expression显示文摘 | Leah R Mundy J | 1989 | Plant Molecular Biology1989，12，： | 1 |
| 17 | Age-related mechanisms of propanil tolerance in jungle-rice, Echinochloa colona 显示文摘 | Leah J M Caseley J C Riches C R | 1995 | Pesticide Science1995，43，4： | 1 |
| 18 | Modelling of cells, stacks and systems based around metal-supported planar IT-SOFC cells with CGO electrolytes operating at 50-600 ℃ 显示文摘 | LEAH R T BRANDON N P AGUIAR P | 2005 | J Power Sources2005，145，： | 1 |
| 19 | Glucose sensor for low-cost lifetime-based sensing using a genetically engineered protein显示文摘 | Leah T Ignacy G Lisa R E | 1999 | Analytical Biochemistry1999，267，1： | 1 |
| 20 | Structure,expression and phylogenetic analysis of the gene encoding actin I in Pneumocystis carinii显示文摘 | LEAH D F JOHN M M RICHARD R T | 1994 | Genetics1994，137，： | 1 |
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