|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Oxaliplatin plus S-1 or capecitabine as neoadjuvant or adjuvant chemotherapy for locally advanced gastric cancer with D2lymphadenectomy: 5-year follow-up results of a phase II-III randomized trial显示文摘Objective: To compare the effect of neoadjuvant chemotherapy(NACT) with adjuvant chemotherapy(ACT)using oxaliplatin plus S-1(SOX) or capecitabine(CapeOX) on gastric cancer patients with D2 lymphadenectomy.Methods: This was a two-by-two factorial randomized phase II-III trial, and registered on ISRCTN registry(No. ISRCTN12206108). Locally advanced gastric cancer patients were randomized to neoadjuvant SOX,neoadjuvant CapeOX, adjuvant SOX, or adjuvant CapeOX arms. Primary analysis was performed on an intentionto-treat(ITT) basis using overall survival(OS) as primary endpoint.Results: This trial started in September 2011 and closed in December 2012 with 100 patients enrolled.Treatment completion rate was 56%, 52%, 38% and 30% in the four arms, respectively. NACT group had fewer dropouts due to unacceptable toxicity(P=0.042). Surgical complication rate did not differ by the four groups(P=0.986). No survival significant difference was found comparing NACT with ACT(P=0.664; 5-year-OS: 70% vs.74% respectively), nor between the SOX and CapeOX groups(P=0.252; 5-year-OS: 78% vs. 66% respectively).Subgroup analysis showed SOX significantly improved survival in patients with diffuse type(P=0.048).Conclusions: No significant survival difference was found between NACT and ACT. SOX and CapeOX had good safety and efficacy as neoadjuvant regimens. Diffuse type patients may survive longer due to SOX. | Kan Xue Xiangji Ying Zhaode Bu Aiwen Wu Zhongwu Li Lei Tang Lianhai Zhang Yan Zhang Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 10 |
| 2 | Oxidation-Induced C--H Functionalization: A Formal Way for C--H Activation显示文摘 | Yichang Liu Hong Yi Aiwen Lei | 2018 | Chinese Journal of Chemistry2018，36，8： | 8 |
| 3 | Electrochemical Intramolecular C-H/O-H Cross-Coupling of 2-Arylbenzoic Acidst显示文摘 | Ailong Shao Na Li Yong Gao Jirui Zhan Chien-Wei Chiang Aiwen Lei | 2018 | Chinese Journal of Chemistry2018，36，7： | 7 |
| 4 | Electrochemical Oxidative Csp^3—H/S—H Cross-Coupling with Hydrogen Evolution for Synthesis of Tetrasubstituted Olefins显示文摘Tetrasubstituted olefins are significant scaffolds as they are prevalent in many biologically active compounds and versatile building blocks for organic synthesis. Herein, we report an electrochemical oxidative Csp^3—H/S—H cross-coupling reaction, in which various tetrasubstituted olefins were prepared under base-free, transition metal-free, and oxidants-free reaction conditions. | Fangling Lu Zengzhuan Yang Tao Wang Tianhao Wang Yuying Zhang Yong Yuan Aiwen Lei | 2019 | Chinese Journal of Chemistry2019，37，6： | 5 |
| 5 | Electrochemical Oxidative C-H Sulfenylation of Imidazopyridines with Hydrogen Evolution显示文摘Summary of main observation and conclusion Selective oxidative C-H sulfenylation of imidazopyridine heterocycles is achieved using an undivided electrolytic cell.The reaction avoids the use of stoichiometric amount of external chemical oxidant and produces hydrogen gas as the only byproduct. Both aryl and aliphatic thiols demonstrate good reactivity for C-S bond formation. | Yong Yuan Yangmin Cao Jin qiao Yueping Lin Xiaomei Jiang Yaqing Weng Shan Tang Aiwen Lei | 2019 | Chinese Journal of Chemistry2019，37，1： | 5 |
| 6 | Recent Applications of Homogeneous Catalysis in Electrochemical Organic Synthesis显示文摘Although the combination of electrochemistry and homogeneous catalysis has proven to be a powerful strategy for achieving a diverse array of novel transformations,some challenges such as controlling the diffusion of catalyst-related species and the instability of catalysts at electrodes remain to be overcome.Herein,we review recent advances in electrochemical homogeneous catalysis,focusing on electrochemical noble-transition-metal catalysis,photoelectrochemical catalysis,and electrochemical enantioselective catalysis.The topics discussed include:(1)how the noblemetal catalystworks in the presence of cathodic hydrogen evolution,(2)how the photocatalyst gets enhanced redox property,and(3)how the enantioselectivity is regulated in a catalytic electrochemical reaction. | Xu Cheng Aiwen Lei Tian-Sheng Mei Hai-Chao Xu Kun Xu Chengchu Zeng | 2022 | CCS Chemistry2022，4，4： | 5 |
| 7 | Synergy of Anodic Oxidation and Cathodic Reduction Leads to Electrochemical C—H Halogenation显示文摘We herein uncovered an electrochemical C—H halogenation protocol that synergistically combines anodic oxidation and cathodic reduction for C—X bond formation. The reaction was demonstrated under exogenous-oxidant-free conditions. Moreover, this is the first example of activating CBr4, CHBr3, and CCl3Br under electrochemical conditions. | Zhilin Zhou Yong Yuan Yangmin Cao Jin Qiao Anjin Yao Jing Zhao Wanqing Zuo Wenjie Chen Aiwen Lei | 2019 | Chinese Journal of Chemistry2019，37，6： | 4 |
| 8 | Tuning radical reactivity for selective radical/radical cross-coupling显示文摘Radical/radical cross-coupling represents a straightforward way for the construction of new chemical bonds in theory and has received more and more attention over the past several years. Until now, it is challenging to achieve the selective bond formation between two transient radicals since selective radical cross-coupling usually happens between persistent radical and transient radical. However, the number of persistent radicals is much less than that of transient radicals. These issues limit the application of radical/radical cross-coupling in the construction of new chemical bonds. To solve this, we proposed a novel strategy ‘‘tuning radical reactivity' that could tune transient radical into persistent radical. This paper will introduce the concept and recent developments of ‘‘tuning radical reactivity'. | Shengchun Wang Shan Tang Aiwen Lei | 2018 | Science Bulletin2018，63，15： | 4 |
| 9 | Photocatalytic decarboxylative coupling between α-oxocarboxylicacids and alkenes显示文摘Photocatalytic decarboxylative cross-coupling which achieves the derivatization of widespread organic acids has become a hot topic in organic synthesis.As special acids,α-oxocarboxylicacids show the great potential in running decarboxylation to construct ketone derivatives.In this article,we have developed a photocatalytic decarboxylative cross-coupling ofα-oxocarboxylic acids and olefins to the synthesis of diverse aryl ketones.Various alkenes andα-oxocarboxylicacids were compatible,generating the desired products in up to 90%yield.Preliminary mechanism studies suggest that a free radical pathway is involved in this process. | Ziyue Chen Fangling Lu Feng Yuan Juanjuan Sun Linyu Du Zhen Li Meng Gao Renyi Shi Aiwen Lei | 2019 | Science China Chemistry2019，62，11： | 2 |
| 10 | Electrochemical Palladium-Catalyzed Intramolecular C-H Amination of 2-Amidobiaryls for Synthesis of Carbazoles显示文摘The synthesis of carbazoles based on the electrochemical Pd-catalyzed intramolecular C-H amination of 2-amidobiaryls through oxidative cross coupling has been achieved under mild reaction conditions.The reaction can be carried out in undivided cell without the addition of external chemical oxidant.Besides good functional group compatibility,the desired carbazoles can be scaled up and modified easily.Compared with previous methods,this protocol affords a simple and sustainable avenue for the construction of car-bazoles. | Qingqing Wang Xiaojing Zhang Pan Wang Xinlong Gao Heng Zhang Aiwen Lei | 2021 | Chinese Journal of Chemistry2021，39，1： | 1 |
| 11 | Simulating the strong ground motion of the 2022 MS6.8 Luding,Sichuan,China Earthquake显示文摘Stochastic finite-fault simulations are effective for simulating ground motions and are widely used in engineering to determine the impacts of ground motion and develop relevant predictive equations.In this study,the source,path,and site amplification coefficient of western Sichuan Province,China,and stochastic finite-fault simulations were used to simulate the acceleration time series,Fourier amplitude spectra,and 5%damped response spectra of 28 strong-motion stations with rupture distances within 300 km of the 2022 MS6.8 Luding earthquake.The simulation results of 14 stations at rupture distances of 45-185 km match the observation.However,the simulation results of 3 near-and 6 far-field stations at rupture distances of 12-36 km and 222-286 km,respectively,were obviously deviated from the observations.Simulation results of the near-field stations are larger than the observations at high frequencies(>6 Hz).The discrepancy likely comes from the nonlinear site effect of near-field stations,which reduced the site amplification at high frequencies.Simulation result of the far-field stations is smaller than the observation at frequencies above 1 Hz.As these stations are located close to the Longmenshan Fault Zone(LFZ),thus,we obtained a new quality factor(Q)from data of historical events and stations located around LFZ.Using the new Q value,the discrepancies of the high-frequency simulation results of the far-field stations were corrected.This result indicated that the laterally varying Q values can be used to address the impact of strong crustal lateral heterogeneity on simulation. | Libao Zhang Lei Fu Aiwen Liu Su Chen | 2023 | Earthquake Science2023，36，4： | 1 |
| 12 | Oxidative cross-coupling: an alternative way for C–C bond formations显示文摘Coupling reaction usually refers to the direct C–C bond formation between two carbon fragments.Generally, cross-coupling reactions between nucleophiles and electrophiles have been extensively studied and become the classic model for bond constructions. Another reaction model, bond formation from two nucleophiles through oxidative cross-coupling, has received more and more attention over the past few years. This paper will discuss the concept of oxidative cross-coupling and give an overview of its recent development. | Zhiyuan Huang Shan Tang Aiwen Lei | 2015 | Science Bulletin2015，60，16： | 1 |
| 13 | Rational Design of a Palladium‐Catalyzed C<sub>sp</sub>–C<sub>sp</sub> Cross‐Coupling Reaction Inspired by Kinetic Studies显示文摘 | Yue Weng Ben Cheng Chuan He Aiwen Lei | 2012 | Angew Chem Int Ed2012，，38： | 1 |
| 14 | Electrooxidation-Induced C(sp^(3))-H/C(sp^(2))-H Radical-Radical Cross-Coupling between Xanthanes and Electron-Rich Arenes显示文摘The arylation of C(sp^(3))-H bonds has been a priority research topic in organic synthesis.Minsici reactions have been the powerful methods for C(sp^(3))-C(sp^(2))bonds formation.Despite its mature development,the scopes of arenes are usually suitable for elec-tron-deficient heterocyclic compounds,rather than electron-rich arenes.Herein,we report an electrooxidation-induced alkylation of electron-rich arenes with H_(2) evolution under exogenous oxidant-free conditions,avoiding the utilization of metal catalysts.This pro-tocol is well performed with various electron-rich aniline derivatives and nitrogen-containing heterocyclic compounds.We anticipate that this electro-oxidative C(sp^(3))-H arylation represents an important expansion for the classic arenes alkylation,thereby proving an attractive strategy for the developments of radical cross-coupling chemistry. | Yuwei Liang Linbin Niu Xing-An Liang Shengchun Wang Pengjie Wang Aiwen Lei | 2022 | Chinese Journal of Chemistry2022，40，12： | 1 |
| 15 | Oxidation-induced ortho-selective C–H bond functionalization of 2-naphthylamine derivative显示文摘Selective C–H bond functionalization has been emerged as a versatile strategy for the construction of new chemical bonds. In the past decades, the directing group(DG)-assisted C–H bond activation has been developed as one of the most efficient methods for selective C–H functionalization. Although a great progress has been made by utilizing this traditional method, developing new strategy for selective C–H bond functionalization is still highly demanded. Hence, a novel oxidation-induced C–H bond functionalization method was demonstrated in this work. By this new method, ortho-C(sp2)–H chlorination of N-substituted 2-naphthylamine was realized in a highly selective manner. | Dongchao Zhang Zhiliang Huang Aiwen Lei | 2018 | Science China Chemistry2018，61，10： | 1 |
| 16 | Electrochemical Dearomative Halocyclization of Tryptamine and Tryptophol Derivatives显示文摘Summary of main observation and conclusion Owing to the easy functionalization of 3-haloindolines to many biologically active compounds,extensive efforts have been made for their efficient preparation.Herein,an electrochemical dearomative bromo-and chloro-cyclization of tryptamine and tryp-tophol derivatives has been developed under undivided electrolytic conditions.In this protocol,neither external chemical oxidants nor harsh conditions are needed,and a wide range of substituted hexahydropyrroloindolines/tetrahydrofuroindolines are obtained with halide ion in high efficiencies.Moreo-ver,this electrolysis could also be scaled up to gram synthesis with good yields. | Kun Liu Yuqi Deng Wenxu Song Chunlan Song Aiwen Lei | 2020 | Chinese Journal of Chemistry2020，38，10： | 1 |
| 17 | Research and development of hot-rolled ultra-high strength steel at Baosteel显示文摘The effects of the composition and cooling process on the microstructures and properties of hot-rolled ultra-high strength low alloy(HSLA)steel,complex phase steel and martensite steel were studied in the laboratory.And S700MC and MP1200 ultra-high strength steels were trial produced at the 1 880 mm hot-rolling line of Baosteel.Compared with conventional hot-rolled high strength products,the idea that water is alloy was applied in the newly developed hot-rolled ultra-high strength steel.By the use of the economical composition design and controlled cooling after hot-rolling effectively,ultra-high strength steel of different steel grades can be obtained. | ZHENG Lei ZHANG Aiwen TANG Wenjun | 2010 | Baosteel Technical Research2010，4，2： | 1 |
| 18 | Oxidative Cross-Coupling Reactions between Two Nucleophiles显示文摘What is the most favorite and original chemistry developed in your research group?Oxidative Cross-Coupling-The chemistry between two'nucleophiles'.How do you get into this specific field?Could you please share some experiences with our readers?My first contact with palladium chemistry was the halopalladation of acetylene in 1998.Then I worked on palladium enolate and found it could initiate a transmetalation reaction.Until 2006,I found that desyl chloride(a halogenated hydrocarbon)showed different reactivity with orga no metallic reagents due to the halophilic and oxyphilic properties,thus we achieved the cross-coupling between two orga no metallic reagents. | Lijun Lu Hao Li Aiwen Lei | 2022 | Chinese Journal of Chemistry2022，40，2： | 1 |
| 19 | Ultra-small Pd clusters supported by chitin nanowires as highly efficient catalysts显示文摘 | Xianglin Pei Yi Deng Bo Duan Ting-Shan Chan Jyh-Fu Lee Aiwen Lei Lina Zhang | 2018 | Nano Research2018，11，6： | 1 |
| 20 | Regioselective electrochemical radical cascade cyclization of internal alkynes to selenated and trifluoromethylated dihydropyran显示文摘Dihydropyran(DHP)compounds are not only found in natural products and bioactive molecules,but also serve as important precursors in organic synthesis.Nonetheless,traditional methods for the construction of such compounds are usually limited to disubstituted DHPs.To address this synthetic challenge,reported here is an efficient electrochemical strategy toward the selenated and trifluoromethylated DHP compounds.The reaction proceeded smoothly under mild electrolysis conditions.The broad substrate scope(>50 examples)and scalable synthesis demonstrated the complexity-building potential of the strategy.Initial mechanistic studies reveal that cyclization may involve a radical process.This protocol may promote the further development of diversified synthesis of multi-substituted dihydropyran. | Mingming Yu Tiantian Huang Lin Zhang Muhammad Shabbir Yuhan Gao Yi-Hung Chen Hong Yi Aiwen Lei | 2023 | Science China Chemistry2023，66，11： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员