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	题名	作者	年代	出处	被引量
1	Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD.	Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao	2017	Bone Research2017，5，1：	9
2	Operator controlled device-to-device communications in LTE-advanced networks显示文摘	LEI L ZHONG Z D LIN C	2012	IEEE Wireless Communications2012，19，3：	1
3	Atmospheric distribution and long-range transport behavior of organochlorine pesticides in North America et al显示文摘	SHEN L WANIA F LEI Y D	2005	Environ Sci Technol2005，，39：	1
4	Cerebral amyloid angiopathies 显示文摘	Masson C Leys D Buee L	2000	Presse Med2000，29，31：	1
5	Atmospheric distribution and long-range transport behavior of organochlorine pesticides in North America et al显示文摘	SHEN L WANIA F LEI Y D	2006	Environ Sci Technol2006，，40：	1
6	查看详情显示文摘	Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y		0，，：	1
7	Clinical outcome in 287 consecutive young adults (15-45years) with ischemic stroke显示文摘	Leys D Bandu L Henon H	2002	Neurology2002，59，：	1
8	Structural and electrochemical sta- bility of CoAl layered double hydroxide in alkali solutions 显示文摘	HU M JI X D LEI L X	2013	Electrochimica Acta2013，105，：	1
9	Develop- ment and calibration of a resin-based passive sampling system for monitoring persistent organ- ic pollutants in the atmosphere显示文摘	WANIA F SHEN L LEI Y D	2003	Environ Sci Technol2003，37，7：	1
10	Investigation on the Bar Clamping Position of a New Type of Precision Cropping System with Variable Frequency Vibration显示文摘	Zhang L J Zhao S D Lei J	2007	International Journal of Machine Tools and Manufacture2007，47，7：	1
11	Characterization of Pgp3, a Chlamydia trachomatis plasmid-encoded immunodominant antigen 显示文摘	Chen D Lei L Lu C	2010	J Bacteriol2010，192，22：	1
12	Direct electron transfer from electrode to electrochemically active bacteria in a bioelectrochemical dechlorination system 显示文摘	LIU D LEI L C YANG B	2013	Bioresource Technology2013，148，：	1
13	Structuring research and development teams in the technological conversion process显示文摘	Cardinal L B Lei D Beyerlein M M	2000	Team Performance Management2000，6，3：	1
14	Preparation and photoluminescence of highly ordered TiO2 nanowire arrays 显示文摘	LEI Y ZHANG L D MENG G W LI G H ZHANG X Y LIANG C H CHEN W WANG S X	2001	Applied Physics Letters2001，78，8：	1
15	Preparation and photoluminescence of highly ordered TiO2 nanowire arrays 显示文摘	Zhang L D	2001	Appl Phys Lett2001，78，：	1
16	Hexachlorocyclohexanes in North American atmosphere 显示文摘	SHEN L WANIA F LEI Y D	2004	Environ Sci Technol2004，38，4：	1
17	Fabrication and characterization of hexagohal mgsoporous silica monolith via post-synthesized hydrothermal process显示文摘	Lei J H Liu D Guo L P	2006	Sol-Gel Sci Techn2006，39，：	1
18	Hapten synthesis and anti- body production for the development of a melamine immunoas- say显示文摘	Lei H T Shen Y D Song L J	2010	Analytica Chimica Acta2010，665，：	1
19	Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos显示文摘	Bao J Lin H Ouyang Y Lei D Osman A Kim TW Mei L Dai P Ohlemiler KK Ambron RT		0，，：	1
20	The effect of cobalt on the electro- chemical performances of Ni-Al layered double hydroxides used in Ni-MH battery 显示文摘	HU M JI X D LEI L X ct al	2013	Journal of Alloys and Compounds2013，578，：	1

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