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| 1 | The association between the genetic polymorphisms of LMP2/LMP7 and the outcomes of HCV infection among drug users显示文摘Objective:To investigate a possible association of LMP2/LMP7 genes with chronic hepatitis C virus(HCV) infection,and to assess whether LMP2/LMP7 genes could influence the outcomes of HCV infection among drug users.Methods:Genomic DNAs of 362 anti-HCV sero-positive drug users and 225 control drug users were extracted from the peripheral blood leukocytes.The sero-positive patients were divided into those who had persistent infection and those who had spontaneously cleared the infection.Polymorphisms of LMP genes were determined by PCR combined with restriction fragment length polymorphism(RFLP).Results:The distribution of LMP2 genotypes among the control,persistent infection and spontaneous clearance groups were not different.However,the LMP7 codon 145 Gln/Lys,Lys/Lys,and Gln/Lys+Lys/Lys genotypes were found significantly more frequent in the persistent infection group than in control group(OR=1.75,95%CI=1.06~2.90;OR=3.16,95%CI=1.23-8.12;OR=1.94,95%CI=1.21-3.12,respectively).Similarly,the frequencies of the codon 145 Gln/Lys,Lys/Lys,and Gln/Lys+Lys/Lys genotypes were found significantly more frequent in the persistent infection group than in the spontaneous clearance group(OR=1.64,95%CI=1.04-2.57;OR=2.40,95%CI=1.09-5.28;OR=1.76,95%CI=1.152.69,respectively).Stratified analysis indicated that combined genotype Gln/Lys+Lys/Lys of the LMP7 gene was related to an increasing susceptibility to HCV infection(OR=1.91,95%CI=1.02-3.55;OR=2.19,95%CI=1.243.89;OR=1.91,95%CI=1.05-3.48,OR=2.86,95%CI=1.41-5.78,respectively)and the risk of persistent HCV infection(OR=1.94,95%CI=1.12-3.34;OR=2.02,95%CI=1.21-3.38;OR=1.78,95%CI=1.12-2.85,OR=2.23,95%CI=1.09-4.58,respectively)among>30-year-old,males,the injection drug user(IDU)subjects and/or the shorter duration drug users(≤5 y).Conclusion:These results suggest that polymorphism of the LMP7 gene may have an influence on the outcomes of HCV infection,and is one of the factors accounting for the genetic susceptibility to HCV infection among drug users. | Qian Cui Yongxiang Zhang Jing Su Chao Shi Na Lei Keqin Ding Jun Li Rongbin Yu L u Wang Ning Wang | 2010 | The Journal of Biomedical Research2010，24，5： | 6 |
| 2 | Cryo-EM structure of human heptameric Pannexin 1 channel显示文摘Dear Editor,Cellular communication is crucial during basic development and in the maintenance of homeostasis in adult organisms,and such communication involves the connexin and pannexin(PANX)families of large-pore channels.The PANX family was identified in 20001 and consists of PANX1,PANX2,and PANX3.2 Among the three subtypes,the most studied is PANX1 because of its potential effects on multiple physiological and pathological functions,3 including microbial infection,cancer progression,ischemia,and neurological disorders.Very recently,we also identified mutations in PANX1 causing familial female infertility characterized by oocyte death.4 PANX1 is a major ATP release and nucleotide permeation channel,which is N-glycosylated and forms three species,GLYO,GLY1,and GLY2.5 Cleavage of the C-terminus by Caspase 3/7 activates the channel and causes the release of ATP and UTP,which functions as a 'find-me'signal during apoptosis. | Ronggui Qu Lili Dong Jilin Zhang Xuekui Y u Lei Wang Shujia Zhu | 2020 | Cell Research2020，30，5： | 4 |
| 3 | Increased circulating level of interleukin-6 and CD8+T cell exhaustion are associated with progression of COVID-19显示文摘Background: Coronavirus disease 2019(COVID-19)is pandemic.It is critical to identify COVID-19 patients who are most likely to develop a severe disease.This study was designed to determine the clinical and epidemiological features of COVID-19 patients associated with the development of pneumonia and factors associated with disease progression.Methods:: Seventy consecutive patients with etiologically confirmed COVID-19 admitted to PLA General Hospital in Beijing,China from December 27,2019 to March 12,2020 were enrolled in this study and followed-up to March 16,2020.Differences in clinical and laboratory findings between COVID-19 patients with pneumonia and those without were determined by theχ2 test or the Fisher exact test(categorical variables)and independent group t test or Mann–Whitney U test(continuous variables).The Cox proportional hazard model and Generalized Estimating Equations were applied to evaluate factors that predicted the progression of COVID-19.Results: The mean incubation was 8.67(95%confidence interval,6.78–10.56)days.Mean duration from the first test severe acute respiratory syndrome coronavirus 2-positive to conversion was 11.38(9.86–12.90)days.Compared to pneumonia-free patients,pneumonia patients were 16.5 years older and had higher frequencies of having hypertension,fever,and cough and higher circulating levels of neutrophil proportion,interleukin-6,low count(<190/µl)of CD8+T cells,and neutrophil/lymphocyte ratio.Thirteen patients deteriorated during hospitalization.Cox regression analysis indicated that older age and higher serum levels of interleukin-6,C-reactive protein,procalcitonin,and lactate at admission significantly predicted the progression of COVID-19.During hospitalization,circulating counts of T lymphocytes,CD4+T cells,and CD8+T cells were lower,whereas neutrophil proportion,neutrophil/lymphocyte ratio,and the circulating levels of interleukin-6,C-reactive protein,and procalcitonin were higher,in pneumonia patients than in pneumonia-free patients.CD8+lymphocyte count in pneumonia patients did not recover when discharged.Conclusions: Older age and higher levels of C-reactive protein,procalcitionin,interleukin-6,and lactate might predict COVID-19 progression.T lymphocyte,especially CD8+cell-mediated immunity is critical in recovery of COVID-19.This study may help in predicting disease progression and designing immunotherapy for COVID-19. | Peng-Hui Yang Yi-Bo Ding Zhe Xu Rui Pu Ping U Jin Yan Ji-Luo Liu Fan-Ping Meng Lei Huang Lei Shi Tian-Jun Jiang En-Qiang Qin Min Zhao Da-Wei Zhang Peng Zhao Ling-Xiang Yu Zhao-Hai Wang Zhi-Xian Hong Zhao-Hui Xiao Qing Xi De-Xi Zhao Peng Yu Cai-Zhong Zhu Zhu Chen Shao-Geng Zhang Jun-Sheng Ji Fu-Sheng Wang Guang-Wen Cao | 2020 | Infectious Diseases of Poverty2020，9，6： | 3 |
| 4 | Paging area optimization based on interval estimation in wireless personal communication networks显示文摘 | CEM U SARAYDAR | 2000 | Mobile Networks and Applications2000，，5： | 1 |
| 5 | Effects of activated carbon surface chemistry and pore structure on the adsorption of organic contaminants from aqueous solution显示文摘 | Li Lei Patricia A Quinlivan Detlif R U Knappe | 2002 | Carbon2002，40，： | 1 |
| 6 | Facile hydro thermal synthesis of novel Bi12 TiO20-Bi2WO6 hetero- structure photocatalyst with enhanced photocatalytic ac- tivity显示文摘 | Xiang Zhang Lei Zhang Jin Song H u | 2015 | Applied Surface Science2015，346，： | 1 |
| 7 | IIR approximation of FIR filters via discrete-time vector fitting显示文摘 | WONG N LEI C U | 2008 | IEEE Transactions on Signal Processing2008，56，3： | 1 |
| 8 | Effects of activated carbon surface chemistry and pose structure on the adsorption of organic contaminants from aqueous solution显示文摘 | LI Lei PATRICIA A Q DETLEF R U K | 2002 | Carbon2002，40，12： | 1 |
| 9 | Passivity Check of S-Parameter Descriptor Systems Via S-Parameter Generalized Hamiltonian Methods显示文摘 | Zhang Z Lei C U Wong N | 2010 | IEEE Trans on Advanced Packaging2010，33，4： | 1 |
| 10 | Bioelectrocatalysis by redox enzymes at modified electrodes显示文摘 | SCHELLER F W WOLLENBERGER U LEI C H | 2002 | Reviews in Moleucular Biotechnology2002，82，： | 1 |
| 11 | Cytochrome c/Clay-modified electrode显示文摘 | Lei C Lisdat F Wollenberger U | 1999 | Electroanalysis1999，11，4： | 1 |
| 12 | Effects of activated carbon surface chemistry and pore structure on the adsorption of organic contaminants from aqueous solution 显示文摘 | Li Lei Patricia A Quinlivan Detlef R U Knappe | 2002 | Carbon2002，40，12： | 1 |
| 13 | Chloride ion activity and susceptibility of Al alloys 7075-T6 and 5083-H131 to stress corrosion cracking显示文摘 | RICKER R E LEE E U TAYLOR R LEI C PREGGER B LIPNICKAS E | 2013 | Metallurgical and Materials Transactions A2013，44，3： | 1 |
| 14 | Chemokine CXCL16 expression suppresses migration and invasiveness and induces apoptosis in breast cancer cells显示文摘 | Fang Y Henderson FC Jr Yi Q Lei Q U Y Chen N | 2014 | Mediators InjZamm2014，2014，47： | 1 |
| 15 | Electron Transfer of Haemoglobin at Electrodes Modified with Colloidal Clay Nanoparticles SP显示文摘 | LEI C WOLLENBERGER U BISTOLAS N | 2002 | Anal Bioanal Chem2002，372，： | 1 |
| 16 | Eicosanoid synthesis in the isolated human renal peivis,ureter and bladder显示文摘 | Zwergel U Zwergel TH Leis HJ et a1 | 1991 | Br J Urol1991，67，3： | 1 |
| 17 | New Opportunities for High-Field In Vivo MRS in Studying Brain Bioenergetics and Function显示文摘 | Xiao-Hong Zhu Fei Du Nanyin Zhang Hao Lei Kamil U?urbil Wei Chen | 2008 | Brain Imaging and Behavior2008，，4： | 1 |
| 18 | Effects of activated carbon characteristics on the simultaneous adsorption of aqueous organic micropollutants and natural organic matter显示文摘 | QUINLIVAN P A LI Lei KNAPPE D R U | 2005 | Water Research2005，39，8： | 1 |
| 19 | Research on the Production Efficiency andUtilizing Rate of Potassium Fertilizer for Rape in Yunnan Province 显示文摘 | Minglian FU Genze U Xiaoyan YUAN Derong CHENG Xuan ZHU Shengguang WEI Hongyan LJ Shi PENG Yuankuan LEI Bin HE Heming WEN Shaowei YU | 2011 | Agricultural Science & Technology2011，12，14： | 1 |
| 20 | Effects of activated carbon surface chemistry and pore structure on the adsorption of organic contaminants from aqueous solution显示文摘 | Patricia A Q Detlef R U K | 2002 | Carbon2002，40，： | 1 |
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