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| 1 | Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis显示文摘background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain unknown.Methods We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral arteries.Stroke mechanism,collateral circulation,and degree and length of stenosis were analysed.The primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or death.Other outcome variables included modified Rankin Scale(mRS)score on discharge and last follow-up.results Of 6369 patients with AIS/TIA,91(1.43%)had ISBAS.Seventy-three(80.2%)patients presented with AIS and 18(19.8%)with TIA.Twenty-nine(31.9%)were women and the median age was 66.8±13.6 years.The mean follow-up time was 2.7 years.The most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral circulation.Approximately 13% of patients with ISBAS presented with complete BA occlusion.Conclusion ISBAS is an uncommon(1.43%)cause of TIA and AIS.Men in their 60s are mostly affected,and artery-to artery embolism is the most common stroke mechanism.Mid-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis. | Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira | 2019 | Stroke & Vascular Neurology2019，4，4： | 10 |
| 2 | Plasma metallopro teinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke显示文摘 | Castellanous M Leira R Serena S | 2003 | Stroke2003，34，： | 1 |
| 3 | Dynamic Response and Fluid/structure Interaction of Submerged Floating Tunnels显示文摘 | SVEIN Remseth BERNT J leira KNUT M Okstad | 1999 | Computers & Structures1999，72，4： | 1 |
| 4 | Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke显示文摘 | Castellanos M Leira R Serena J | 2003 | Stroke2003，34，1： | 1 |
| 5 | Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke显示文摘 | Castellanos M Leira R Serena J | 2003 | Stroke2003，34，1： | 1 |
| 6 | Determination of DSP toxins:comparative study of HPLC and bioassay to reduce the observation time of the mouse bioassay 显示文摘 | Vieites J M Leira F Botana L M | 1996 | Arch Toxicol1996，70，44： | 1 |
| 7 | Topiramate for patients with refractory migraine:an observational,multiccnter study in Spain显示文摘 | Pascual J Sanchez del Rio M Mateos V Lainez JM HernandezGallego J Leira R | 2003 | Neurologia2003，18，7： | 1 |
| 8 | Hyperthermia is a surrogate marker of inflammation - mediated cause of brain damage in acute ischemic stroke显示文摘 | LEIRA R RODRIGUEZ -YANEZ M CASTELLANOS M | 2006 | J Intern Med2006，260，4： | 1 |
| 9 | Metalloproteinases and neurovas-cu- lar injury 显示文摘 | Castillo J Leira R Blanco M | 2004 | Neurologia2004，19，6： | 1 |
| 10 | Age determines the effects of blood preessure lowerig during the acute phase of ishemic stroke: The TICA study显示文摘 | Leira R Millan M Diez-Tejedor E | 2010 | Hypertension2010，54，4： | 1 |
| 11 | Plasma metalloproteinase- 9 concentration predicts hemorrhagic transformation in acute ische- mic stroke显示文摘 | Castellanos M Leira R Serena J | 2003 | Stroke2003，34，： | 1 |
| 12 | Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke显示文摘 | Castellanous M Leira R Serena J | 2003 | Stroke2003，34，： | 1 |
| 13 | Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke显示文摘 | Castellanos M Leira R Serena J | 2003 | Stroke2003，34，1： | 1 |
| 14 | Dynamic response and fluid/structure interaction of submerged floating tunnels 显示文摘 | REMSETH S LEIRA J B OKSTAD M K | 1999 | Computers and Structures1999，72，： | 1 |
| 15 | Plasma metalloproteinase -9 concentration predicts hemorrhagic transfonnation in acute ischemicstroke显示文摘 | Castellanos M Leira R Serena J | 2003 | Stroke2003，34，1： | 1 |
| 16 | Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke显示文摘 | Castellanos M Leira R Serena J | 2003 | Stroke2003，34，5： | 1 |
| 17 | Predictors of good outcome in medium to large spontaneous supratentorial intracerebral haemorrhages显示文摘 | Leira R Tejada J | 2005 | J Neurol Neurosurg Psychiatry2005，76，： | 1 |
| 18 | Hyperthermia is a surrogate marker of inflammation-mediated cause of brain damage in a- cute ischaemic stroke 显示文摘 | Leira R Rodriguez-yanez M Castellanos M | 2006 | J Intern Med2006，260，4： | 1 |
| 19 | Plasma cellular fibronectconcentration predicts hemorrhagic transformation after thrombolytictherapy in acute ischemic stroke 显示文摘 | Castellanos M Leira R Serena J | 2004 | Stroke2004，35，7： | 1 |
| 20 | Effects of water-level fluctuations on lakes: An annotated bibliography 显示文摘 | Leira M Cantonati M | 2008 | Hydrobiologia2008，613，： | 1 |
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