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| 1 | Orthopedic disorders of the knee in hemophilia:A current concept review显示文摘The knee is frequently affected by severe orthopedic changes known as hemophilic arthropathy(HA) in patients with deficiency of coagulation factor Ⅷ or Ⅸ and thus this manuscript seeks to present a current perspective of the role of the orthopedic surgeon in the management of these problems.Lifelong factor replacement therapy(FRT) is optimal to prevent HA,however adherence to this regerous treatment is challenging leading to breakthrough bleeding.In patients with chronic hemophilic synovitis,the prelude to HA,radiosynovectomy(RS) is the optimal to ameliorate bleeding.Surgery in people with hemophilia(PWH) is associated with a high risk of bleeding and infection,and must be performed with FRT.A coordinated effort including orthopedic surgeons,hematologists,physical medicine and rehabilitation physicians,physiotherapists and other team members is key to optimal outcomes.Ideally,orthopedic procedures should be performed in specialized hospitals with experienced teams.Until we are able to prevent orthopedic problems of the knee in PWH will have to continue performing orthopedic procedures(arthrocentesis,RS,arthroscopic synovectomy,hamstring release,arthroscopic debridement,alignment osteotomy,and total knee arthroplasty).By using the aforementioned procedures,the quality of life of PWH will be improved. | E Carlos Rodriguez-Merchan Leonard A Valentino | 2016 | World Journal of Orthopedics2016，7，6： | 9 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | 平衡试验和平衡反应—脑卒中后的能力变化显示文摘平衡评定是许多病人特别是脑卒中病人康复评定的一个组成部分。许多研究表明卒中病人有平衡损伤。临床上虽采取了各种方法来训练卒中病人的平衡能力,包括体重转移,生物反馈和斜板训练,但有关这些训练效果的报道较少。本文旨在回顾卒中病人在平衡反应和平衡试验中的变化以及有关平衡治疗效果的研究。姿势摇摆静站时姿势摇摆,健康人15~60岁基本相似,小于15岁或大于60岁明显增加。 | Leonard E 燕铁斌 | 1991 | 国外医学(物理医学与康复学分册)1991，11，2： | 5 |
| 4 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 5 | Iontophoresis enhanced absorptive flux of polar molecules across intestinal tissue in vitro 显示文摘 | Leonard M Creed E Brayden D | 2000 | Pharmaceutical Research2000，17，4： | 1 |
| 6 | Sentinel node localization should be interpreted with caution in midline vulvar cancer显示文摘 | Louis-Sylvestre C Evangelista E Leonard F | 2005 | Gynecol Oncol2005，97，： | 1 |
| 7 | Coordinated patterns of unit speed particles on a closed curve显示文摘 | ZHANG F LEONARD N E | 2007 | Systems and Control Letters2007，56，6： | 1 |
| 8 | Antichymotrypsin is the Human Plasma Inhibitor of Macrophage Ectoenzymes That Cleave Pro-macrophage Stimulating Protein显示文摘 | Skeel A Leonard E J | 2001 | J Biol Chem2001，276，21： | 1 |
| 9 | Chronic kidney disease and bone fracture : a growing concern 显示文摘 | Nickolas TL Leonard MB Shane E | 2008 | Kidney Int2008，74，6： | 1 |
| 10 | Cooperative control of mobile sensor networks: Adaptive gradient climbing in a distributed environment显示文摘 | Ogren P Fiorelli E Leonard N E | 2004 | Automatic Control2004，49，8： | 1 |
| 11 | Strain improve- ment of recombinant Escherichia coli for efficient produc- tion of plant flavonoids 显示文摘 | Leonard E Yan Y Fowler Z L | 2008 | Molecular Pharmaceutics2008，5，2： | 1 |
| 12 | Model-based feedback control of autonomous underwater gliders 显示文摘 | LEONARD N E CRAVER J G | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 13 | Evaluation of the Caco-2 monolayer as a model epithelium for iontophoretic transport 显示文摘 | Leonard M Creed E Brayden D | 2000 | Pharmaceutical Research2000，17，10： | 1 |
| 14 | Chronic kidneydisease and bone fracture: a growing concern 显示文摘 | Nickolas TL Leonard MB Shane E | 2008 | Kidney Int2008，74，6： | 1 |
| 15 | Polyvinyl alcohol-coated macroporous polystyrene particles as stationary phases for the chromatography of protein 显示文摘 | Leonard M Fournier C Dellacherie E | 1995 | Journal of Chromatography B1995，664，： | 1 |
| 16 | Environmental Pollution显示文摘 | de Boer Jacob Wester Peter G van der Horst Aschwin Leonard Pim E G | 2003 | 122 : 632003，122，： | 1 |
| 17 | Lp norms and the Sinc function显示文摘 | Borwein D Borwein J M Leonard I E | 2010 | American Mathematical Monthly2010，117，6： | 1 |
| 18 | Self-care and quality of life ofheart failure patients at a multidisciplinary heart function clinic显示文摘 | Seto E Leonard KJ Cafazzo JA | 2011 | J Card-iovasc Nurs2011，26，5： | 1 |
| 19 | An assess-ment of the effects of central interleukin-1茁,-2,-6and tumornecrosis factor alpha administration on some behaviouralneurochemical endocrine and immune parameters in the rat显示文摘 | CONNOR T J SONG C LEONARD B E | 1998 | Neuroscience1998，84，3： | 1 |
| 20 | Statistical Inference for Probabilistic Functions of Finite State Markov Chains 显示文摘 | Leonard E B Ted P | 1966 | The Annals of Mathemat- ical Statistics1966，37，6： | 1 |
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