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| 1 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 2 | Effective mass and Fermi surface complexity factor from ab initio band structure calculations显示文摘The effective mass is a convenient descriptor of the electronic band structure used to characterize the density of states and electron transport based on a free electron model.While effective mass is an excellent first-order descriptor in real systems,the exact value can have several definitions,each of which describe a different aspect of electron transport.Here we use Boltzmann transport calculations applied to ab initio band structures to extract a density-of-states effective mass from the Seebeck Coefficient and an inertial mass from the electrical conductivity to characterize the band structure irrespective of the exact scattering mechanism.We identify a Fermi Surface Complexity Factor:N_(v)^(*)K^(*) from the ratio of these two masses,which in simple cases depends on the number of Fermi surface pockets eN_(v)^(*) T and their anisotropy K^(*),both of which are beneficial to high thermoelectric performance as exemplified by the high values found in PbTe.The Fermi Surface Complexity factor can be used in high-throughput search of promising thermoelectric materials. | Zachary M.Gibbs Francesco Ricci Guodong Li Hong Zhu Kristin Persson Gerbrand Ceder Geoffroy Hautier Anubhav Jain G.Jeffrey Snyder | 2017 | npj Computational Materials2017，，1： | 11 |
| 3 | The Development of Protein Microarrays and Their Applications in DNA-Protein and Protein-Protein Interaction Analyses of Arabidopsis Transcription Factors显示文摘 | Wei Gong Kun He Mike Covington S. R Dinesh-Kumar Michael Snyder Stacey L. Harmer Yu-Xian Zhu Xing Wang Denga | 2008 | Molecular Plant2008，1，1： | 7 |
| 4 | Grain boundary engineering with nano-scale InSb producing high performance In_(x)Ce_(y)Co_(4)Sb_(12+z)skutterudite thermoelectrics显示文摘Thermoelectric semiconductors based on CoSb_(3)hold the best promise for recovering industrial or automotive waste heat because of their high efficiency and relatively abundant,lead-free constituent elements.However,higher efficiency is needed before thermoelectrics reach economic viability for widespread use.In this study,n-type In_(x)Ce_(y)Co_(4)Sb_(12+z)skutterudites with high thermoelectric performance are produced by combining several phonon scattering mechanisms in a panoscopic synthesis.Using melt spinning followed by spark plasma sintering(MS-SPS),bulk In_(x)Ce_(y)Co_(4)Sb_(12+z)alloys are formed with grain boundaries decorated with nano-phase of InSb.The skutterudite matrix has grains on a scale of 100-200 nm and the InSb nano-phase with a typical size of 5e15 nm is evenly dispersed at the grain boundaries of the skutterudite matrix.Coupled with the presence of defects on the Sb sublattice,this multi-scale nanometer structure is exceptionally effective in scattering phonons and,therefore,InxCey-Co_(4)Sb_(12)/InSb nano-composites have very low lattice thermal conductivity and high zT values reaching in excess of 1.5 at 800 K. | Han Li Xianli Su Xinfeng Tang Qingjie Zhang Ctirad Uher G.Jeffrey Snyder Umut Aydemir | 2017 | Journal of Materiomics2017，3，4： | 7 |
| 5 | Calculation and Simulation of Evapotranspiration of Applied Water显示文摘The University of California,Davis and the California Department of Water Resources have developed a weather generator application program 'SIMETAW' to simulate weather data from climatic records and to estimate reference evapotranspiration (ET o) and crop evapotranspiration (ET c) with the generated simulation data or with observed data.A database of default soil depth and water holding characteristics,effective crop rooting depths,and crop coefficient (K c) values to convert ET o to ET c are input into the program.After calculating daily ET c,the input and derived data are used to determine effective rainfall and to generate hypothetical irrigation schedules to estimate the seasonal and annual evapotranspiration of applied water (ET aw),where ET aw is the net amount of irrigation water needed to produce a crop.In this paper,we will discuss the simulation model and how it determines ET aw for use in water resources planning. | Richard L Snyder Shu Geng Morteza Orang Sara Sarreshteh | 2012 | Journal of Integrative Agriculture2012，11，3： | 7 |
| 6 | Thermal conductivity of complex materials显示文摘In the discussion and analysis of thermal properties(e.g.heat capacity,thermal conductivity)the Debye approximation is typically used to describe the collective behavior of lattice vibrations(phonons)in solid materials.Because the Debye model has been successful in explaining many properties of materials,particularly in contrast to the non-dispersive model considered by Einstein,the Debye model is often the starting point of introductory textbooks in solid state physics.Yet the more we learn about the full spectrum of lattice vibrations. | G.Jeffrey Snyder Matthias T.Agne Ramya Gurunathan | 2019 | National Science Review2019，6，3： | 6 |
| 7 | 茶园防霜机不同时间尺度作用效果研究显示文摘在发生晚霜的茶园中,试验研究了防霜机不同时间尺度启闭的防霜效果。在茶树萌芽前不同天数、降霜前和日出后不同时间,分别设定开始启用和启闭防霜机的处理,测定其对茶树生长、冠层温度和防霜范围的影响。结果表明:在茶树萌芽前20、15、7 d开始启用防霜机,使新梢长度、芽密度和百芽质量均比对照增加20%以上;防霜机在降霜前2.0、1.5、1.0 h启动,对茶树防霜效果更显著,作用半径比对照增大60%以上;防霜机在日出后2.0、1.5、1.0 h延停,在开始的1 h内可平均减缓冠层温升45.76%,并减小茶树叶片光合强度的降幅。所以,晚霜时为保持茶树较好的长势和产量,应在茶树萌芽前不少于7 d开始启用防霜机,且合适的启动和延停时机分别为降霜前1.0 h和日出后1.0 h。 | 胡永光 朱霄岚 赵梦龙 Richard L Snyder 李萍萍 | 2013 | 农业机械学报2013，44，12： | 6 |
| 8 | 药物重整:美国俄亥俄州两家医院的成功经验显示文摘药物重整(Medication Reconciliation)是指在药物治疗的每个不同阶段(如患者入院、转科或出院时),医疗卫生人员(医师、护士或药师)通过复核及沟通患者在医疗交接前后的用药情况,对患者所用药物和过敏史等情况进行详细全面的记录,来保证患者用药安全。 药物重整具体流程如下:首先,医疗卫生人员(医师、护士或药师)收集整理患者药物治疗记录,制定监测和评估计划;其次,问诊前打印第一步的药物治疗清单;第三,问诊时向患者提供药物治疗清单,患者更新并确认该清单;第四,与患者再次确认清单内容无误;第五,更新患者治疗记录。最后,当患者转到另外一个治疗场所或达到另外一个治疗阶段后,再重复第一步。 | Kathleen Cubera David Custodio Mary Starbuck Denise Snyder | 2012 | 中国继续医学教育2012，4，2： | 5 |
| 9 | 肩关节镜下单排缝合技术治疗肩袖撕裂显示文摘目的探讨肩关节下南加州骨科研究所单排缝合技术(SCOI row)治疗大中型肩袖撕裂的疗效。方法对2018年6月至2018年8月南方医科大学第五附属医院关节外科使用SCOI row技术缝合治疗的大中型肩袖撕裂患者进行回顾性研究。纳入中型或者大型肩袖撕裂,排除依从性较差合并其他损伤的患者,共纳入26例患者,男10例,女16例;平均年龄(64±5)岁。SCOI row技术即采用单排3线锚钉固定结合足印区周围扩多个骨髓孔技术。术前关节镜下测量肩袖撕裂范围为2~4 cm,其中冈上肌撕裂9例(34.6%),冈上肌、肩胛下肌撕裂11例(42.4%),冈上肌、冈下肌、肩胛下肌撕裂3例(11.5%),冈上肌、冈下肌撕裂3例(11.5%)。术后6个月通过MRI评判肩袖是否愈合,测量足印区新组织厚度,比较术前与术后6个月疼痛视觉模拟评分(VAS)及肩关节功能评分(UCLA)及肩关节主、被动活动度。术前与术后6个月的数据比较采用配对t检验。结果所有患者术后获(7.9±1.6)个月随访。术前、术后6个月VAS评分分别为(6.5±1.7)、(2.1±0.8)分,差异有统计学意义(t=10.225,P<0.05)。UCLA评分术前为(12.7±3.8)、术后6个月(31.1±1.6)分,差异有统计学意义(t=-3.066,P<0.05)。术后6个月足印区新组织厚度平均为(7.08±0.28)mm。术后6个月患者被动前屈、主动前屈、被动外展、主动外展、中立位被动外旋、中立位主动外旋活动度分别为(162.1±10.5)°、(155.3±38.5)°、(138.2±29.3)°、(130.4±22.4)°、(26.2±8.2)°、(15.3±7.3)°,均较术前明显提高(t=-7.913、-11.263、-8.286、-7.285、-11.734、-4.891,均为P<0.05)。术后6个月MRI显示肩袖撕裂足印区完全愈合为24例,再次撕裂2例,愈合率92.3%。结论SCOI row技术缝合肩袖撕裂通过MRI评判愈合较高,肩关节功能恢复较好,疼痛缓解,是一种治疗肩袖撕裂的有效方法。 | 何河北 潘乘龙 李宝龙 宋斌 Stephen Snyder 王涛 胡勇 朱惠峰 陈玉书 | 2020 | 中华关节外科杂志(电子版)2020，14，4： | 5 |
| 10 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 11 | 利用LC/Q-TOF和Mass Profiler Professional软件筛查水中新兴化学污染物显示文摘利用Agilent 6540 Q-TOF LC/MS和Agilent Mass Profiler Professional软件(MPP)灵敏地表征城市污水中复杂的化学成分.通过MPP多变量统计分析软件包对Q-TOF高分辨质谱数据进行处理,揭示了在污水处理过程中有机化学品分布类型的变化.利用这项技术能够测定循环水臭氧氧化过程中有机污染物的减少、反弹和形成.MPP的热图提供了分布图,可用来评估水质的细微变化并鉴别特定水源或处理过程中特有的新兴污染物. | Sylvain Merel Shane Snyder | 2016 | 环境化学2016，35，3： | 5 |
| 12 | Role of simple biomarkers in predicting fibrosis progression in HCV infection显示文摘AIM: To examine the accuracy of the aspartate aminotransferase (AST)/Platelet Ratio Index (APRI) and FIB-4, in predicting longitudinal changes in liver histology in hepatitis C virus (HCV) patients.METHODS: Patients that underwent repeat liver biopsies at least 1 year apart from 1999 to 2007 were identified. Liver fibrosis was staged on needle core biopsies evaluated by a single expert liver pathologist. Only laboratory values within 3 mo of the liver biopsies were used.RESULTS: Thirty-six patients met the inclusion criteria with 50% stage 1 on initial biopsy, 25% stage 2, and 22% stage 3. Nineteen of 36 (53%) had progression of fibrosis on repeat biopsies, while 16 (44%) showed no change in stage, and one (3%) showed improvement. Patients that showed progression of fibrosis had significantly higher alanine aminotransferase and aspartate aminotransferase levels than the group that did not show progression. A significant correlation was seen between change in stage of fibrosis and change in APRI (r2 = 0.39, P = 0.00001) and a change in FIB-4 (r2 = 0.31, P = 0.00004). A change in APRI (ΔAPRI) of 0.18 had 80% positive predictive value (PPV) and 67% nega- tive predictive value (NPV) for progression of fibrosis. A change in FIB-4 (ΔFIB-4) of 0.39 had 75% PPV and 75% NPV for predicting progression of fibrosis. CONCLUSION: ΔAPRI and ΔFIB-4 parallel changes in fibrosis progression, and could be useful tools for clinicians in following patients with active chronic HCV infection. | Rajasekhara R Mummadi John R Petersen Ned Snyder | 2010 | World Journal of Gastroenterology2010，16，45： | 4 |
| 13 | No country is an island in regulating food safety:How the WTO monitors Chinese food safety laws through the Trade Policy Review Mechanism(TPRM)显示文摘Established within the framework of the World Trade Organization(WTO),the Trade Policy Review Mechanism(TPRM) reviews periodically the trade policies of all WTO Members. The review includes many aspects of food safety regulation. China's trade policy is reviewed every two years. This paper analyses in detail the reviews of China's trade policy in 2006,2008,2010,2012 and 2014. It focuses in particular on food safety laws and types of standards,alignment of domestic standards with international standards,the role of different domestic institutions,transparency and notification of food safety measures under the WTO agreements on Sanitary and Phytosanitary Measures(SPS) and on Technical Barriers to Trade(TBT Agreement),import and export,and geographical indications(GIs). It concludes that the WTO TPRM can contribute,within its mandate,to reform of Chinese food safety laws and improvement of food safety in China. It notes that China has already undertaken substantial reforms of its system for regulating food safety. It recommends that China should continue to participate actively in the TPRM,follow its own path with regard to alignment and learn selectively from other WTO Members. | Francis Snyder | 2015 | Journal of Integrative Agriculture2015，14，11： | 4 |
| 14 | Genomic era diagnosis and management of hereditary and sporadic colon cancer显示文摘The morbidity and mortality attributable to heritable and sporadic carcinomas of the colon are substantial and affect children and adults alike. Despite current colonoscopy screening recommendations colorectal adenocarcinoma(CRC) still accounts for almost 140000 cancer cases yearly. Familial adenomatous polyposis(FAP) is a colon cancer predisposition due to alterations in the adenomatous polyposis coli gene, which is mutated in most CRC. Since the beginning of the genomic era next-generation sequencing analyses of CRC continue to improve our understanding of the genetics of tumorigenesis and promise to expand our ability to identify and treat this disease. Advances in genome sequence analysis have facilitated the molecular diagnosis of individuals with FAP, which enables initiation of appropriate monitoring and timely intervention. Genome sequencing also has potential clinical impact for individuals with sporadic forms of CRC, providing means for molecular diagnosis of CRC tumor type, data guiding selection of tumor targeted therapies, and pharmacogenomic profiles specifying patient specific drug tolerances. There is even a potential role for genomic sequencing in surveillance for recurrence, and early de-tection, of CRC. We review strategies for diagnostic assessment and management of FAP and sporadic CRC in the current genomic era, with emphasis on the current, and potential for future, impact of genome sequencing on the clinical care of these conditions. | Edward David Esplin Michael Paul Snyder | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 15 | Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study显示文摘 | William C Huang Andrew S Levey Angel M Serio Mark Snyder Andrew J Vickers Ganesh V Raj Peter T Scardino Paul Russo | 2006 | Lancet Oncology2006，，9： | 4 |
| 16 | Functional Analysis of a Rice Oxidosqualene Cyclase through Total Gene Synthesis显示文摘Dear Editor, Plants produce a large range of triterpenoids that serve as chemical defenses against pathogens.For example,β-amyrin synthase (AsbAS1) performs the initial enzymatic step in the biosynthesis of the potent antimicrobial avencins in oats (Haralampidis et al.,2001).Additionally,other triterpenoids such as glycyrrhizin and QS21 are known to have beneficial or detrimental effects for human health (Osbourn et al.,2011).For some time,heterologous expression of plant oxidosqualene cyclases (OSCs) in yeast has been a powerful methodology for the functional characterization of this important family of triterpene biosynthetic enzymes.The foundational work in this area employed the lanosterol-deficient Saccharomyces cerevisiae strain SMY1 to characterize the function of Arabidopsis thaliana cycloartenol synthase (CAS)(Corey et al.,1993). | Juncong Sun Xia Xu Zheyong Xue John Hugh Snyder Xiaoquan Qi | 2013 | Molecular Plant2013，6，5： | 4 |
| 17 | Microstructure and composition engineering Yb single-filled CoSb_(3) for high thermoelectric and mechanical performances显示文摘A broad tunability of the thermoelectric and mechanical properties of CoSb_(3) has been demonstrated by adjusting the composition with the addition of an increasing number of elements.However,such a strategy may negatively impact processing repeatability and composition control.In this work,singleelement-filled skutterudite is engineered to have high thermoelectric and mechanical performances.Increased Yb filling fraction is found to increase phonon scattering,whereas cryogenic grinding contributes additional microstructural scattering.A peak zT of 1.55 and an average zT of about 1.09,which is comparable to the reported results of multiple-filled SKDs,are realized by the combination of simple composition and microstructure engineering.Furthermore,the mechanical properties of Yb single-filled CoSb_(3) skutterudite are improved by manipulation of the microstructure through cryogenic grinding.These findings highlight the realistic prospect of producing high-performance thermoelectric materials with reduced compositional complexity. | Zhenxing Zhou Matthias T.Agne Qihao Zhang Shun Wan Qingfeng Song Qing Xu Xiaofang Lu Shijia Gu Yuchi Fan Wan Jiang Gerald Jeffrey Snyder Lianjun Wang | 2019 | Journal of Materiomics2019，5，4： | 4 |
| 18 | 番茄野生种L.pennellii核心种质抗虫性初步评价显示文摘以番茄属中近源野生种L.pennellii的16份核心种质为试材,开展对红蜘蛛和蚜虫抗虫特性的鉴定和评估。结果表明,16份核心种质中除LA1920高感红蜘蛛外,其余15份均对红蜘蛛表现出明显的抗性。15份抗红蜘蛛的材料中,1份表现免疫,12份表现高抗。试验还表明,16份材料对蚜虫均表现出很高的抗性,野生材料单株上的蚜虫数均明显少于栽培番茄,其中9份材料对蚜虫表现免疫,7份表现高抗。 | 柴敏 于拴仓 姜立纲 唐晓伟 John Snyder | 2006 | 华北农学报2006，21，5： | 4 |
| 19 | Cell Stem Cell:利用干细胞制造出的心肌细胞有助精准心血管医疗取得进展显示文摘在一项新的研究中。来自美国斯坦福大学医学院的研究人员发现利用人诱导性多能干细胞(iPS细胞)制造的心肌细胞忠实地反映供者天然的心脏组织中关键基因的表达模式。因此,这些细胞能够被用来预测病人是否可能经历药物相关的心脏损伤。相关研究结果在线发表在Cell Stem Cell期刊上。论文标题为"Transcriptome Profiling of Patient -Specific Human iPSC - ardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro". | Elena Matsa Paul W. Burridge Kun-Hsing Yu John H. Ahrens Vittavat Termglinchan Haodi Wu Chun Liu Praveen Shukla Nazish Sayed Jared M. Churko Ningyi Shao Nicole A. Woo Alexander S. Chao Joseph D. Gold Ioannis Karakikes Michael P. Snyder Joseph C. Wu | 2016 | 现代生物医学进展2016，0，32： | 4 |
| 20 | 圈养大熊猫性情、饲养管理和社群-性行为的关系(英文)显示文摘以往研究表明,许多成年雄性大熊猫在圈养状态下不能表达正常的社群性行为。我们设计了一个实验来研究大熊猫正常社群性行为与性情特征、展示、以及饲养管理的关系。通过调查获得大熊猫展示和饲养管理的数据,询问饲养员得知2001年繁殖季节中大熊猫的社群性行为发生频次,然后评估社群性行为能力。研究对象是分布在中国4个繁育中心的37头(12头雄性和25头雌性)成体大熊猫。通过提供新物品和气味来评估大熊猫情绪反应状况。情绪反应分为3类:畏惧、访问和访问玩耍。在有饲养员陪同玩耍的一组里,雌、雄大熊猫的'访问玩耍'的分值都较高。'畏惧'类的雌性大熊猫气味标记行为少,表达的性行为也少,并且更多地攻击接近它们的雄性,或者不理睬雄性。在繁殖季节前就接近雄性大熊猫围栏的雌性,表现出更多的气味标记行为和性行为。这些雌性的'访问玩耍'分值也高。'访问'分值高的雄性大熊猫,接近雌性的行为更多。那些与饲养员接触时间少的雄性大熊猫倾向于攻击雌性,与那些攻击性小的雄性相比,这些雄性倾向于能够接受丰富性低的环境。这些结果表明,应该采取措施减少大熊猫的畏惧,在大熊猫和饲养员之间建立积极的关系,在繁殖季节之前,增加雌性和雄性之间的熟悉程度。 | David POWELL 林虹 Kathy CARLSTEAD Devra KLEIMAN 张和民 张贵权 张志和 余建秋 张金国 卢雁平 Timothy S.K.NG Jason C.L.TANG Rebecca SNYDER | 2008 | 动物学报2008，54，1： | 3 |
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