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15篇 您的检索式：作者名="LEOPOLD PL"

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		题名	作者	年代	出处	被引量
	1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
	2	Modification of gene expression of the small airway epithelium in response to cigarette smoking显示文摘	Harvey BG Heguy A Leopold PL	2007	J Mol Med (Bed)2007，85，1：	1
	3	Smoking is associat- ed with shortened airway cilia显示文摘	Leopold PL O'Mahony MJ Lian XJ	2009	PLoS One2009，4，12：	1
	4	Smoking is associated with shortened airway cilia显示文摘	Leopold PL O'Mahony MJ Lian XJ	2009	PLoS One2009，4，12：	1
	5	Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog显示文摘	Sato N Leopold PL Crystal RG	1999	J Clin Invest1999，104，7：	1
	6	Adenovirus-mediated transfer of a minigene expressing multiple isoforms of VEGF is more effective at inducing angiogenesis than comparable vectors expressing individual VEGF cDNAs显示文摘	Whitlock PR Hackett NR Leopold PL	2004	Mol Ther2004，9，1：	1
	7	Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia显示文摘	Sato N Leopold PL Crystal RG	2001	J Natl Cancer Inst2001，93，24：	1
	8	Intntpleural administration of a serotype 5 adeno-associated virus coding for alphal-antitrypsin mediates persistent, high lung and serum levels of alphal-antitrypsin显示文摘	De B Heguy A Leopold PL	2004	Mol Ther2004，10，6：	1
	9	Adenovirus serotype 7 retention in a late endosomal compartment prior to cytosol escape is modulated by fiber protein显示文摘	Miyazawa N Crystal RG Leopold PL		0，，03：	1
	10	Smoking is associated with shortened airway cilia显示文摘	Leopold PL O'Mahony MJ Lian XJ	2009	PLoS One2009，4，：	1
	11	A comparison of epithe- lial-to-mesenchymal transition and reepithelialization 显示文摘	Leopold PL Vincent J Wang H	2012	Semin Cancer Biol2012，22，：	1
	12	Human em- bryonic stem cells and gene therapy显示文摘	Strulovici Y Leopold PL O'connor TP	2007	Mol Ther2007，15，5：	1
	13	Induction of the hair growth phase in postnatal mice by localized, transient expression of Sonic hedgehog显示文摘	Sato N Leopold PL Crystal RG	1999	J Clin Invest1999，104，7：	1
	14	Role of alveolar macrophages in rapid elimination of adenovirus vectors administered to the epithelial surface of the respiratory tract 显示文摘	WORGALL S LEOPOLD PL WOLFF G	1997	Hum Gene Ther1997，8，14：	1
	15	Association of adenovirus withthe microtubule organizing center 显示文摘	Bailey CJ Crystal RG Leopold PL	2003	J Virol2003，77，13：	1

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