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| 1 | Lithospheric Electrical Structure across the Eastern Segment of the Altyn Tagh Fault on the Northern Margin of the Tibetan Plateau显示文摘Project INDEPTH(Inter National DEep Profiling of Tibet and the Himalaya) is an interdisciplinary program designed to develop a better understanding of deep structures and mechanics of the Tibetan Plateau. As a component of magnetotelluric(MT) work in the 4th phase of the project, MT data were collected along a profile that crosses the eastern segment of the Altyn Tagh fault on the northern margin of the plateau. Time series data processing used robust algorithms to give high quality responses. Dimensionality analysis showed that 2D approach is only valid for the northern section of the profile. Consequently, 2D inversions were only conducted for the northern section, and 3D inversions were conducted on MT data from the whole profile. From the 2D inversion model, the eastern segment of the Altyn Tagh fault only appears as a crustal structure, which suggests accommodation of strike slip motion along the Altyn Tagh fault by thrusting within the Qilian block. A large-scale off-profile conductor within the mid-lower crust of the Qilian block was revealed from the 3D inversion model, which is probably correlated with the North Qaidam thrust belt. Furthermore, the unconnected conductors from the 3D inversion model indicate that deformations in the study area are generally localized. | ZHANG Letian YE Gaofeng JIN Sheng WEI Wenbo Martyn UNSWORTH Alan G.JONES JING Jianen DONG Hao XIE Chengliang Florian LE PAPE Jan VOZAR | 2015 | Acta Geologica Sinica(English Edition)2015，89，1： | 1 |
| 2 | Mechanisms and applications of antitumor immunotherapy of responsive drug-loaded nanoparticles in breast cancer显示文摘During the chemotherapy of tumors,the cytotoxic effect of drugs is vital to kill tumor cells,and the delivery of a chemotherapeutic agent is of great importance for optimal therapeutic effects.The high in vivo clearance rate and low delivery efficiency of conventional chemotherapeutic agents affect the therapeutic effect.In recent years,the responsive drug delivery nanosystem has received increasing concern owing to its excellent biocompatibility,stable delivery performance,and controlled drug release strategies.To lucidly explain the cytocidal and immunotherapeutic effects of such responsive nanosystems in breast cancer,this review discusses the various stimuli and responses of drug-loaded liposomal nanosystems.The light/magnetic response of drug-loaded bionic membranes nanosystems and the heat/magnetic response of drug-loaded iron oxide nanosystems are also elaborated.Their cancer cell-killing efficacy and antitumor immunotherapeutic effects are also scrutinized. | LETIAN JIN HETING CHEN QI RUAN RUI LIU YIFENG FAN XIUFANG XU DAJIANG WANG JIAHUI LU | 2023 | BIOCELL2023，47，7： | 0 |
| 3 | The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation显示文摘The coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a severe global health crisis;its structural protein envelope(E)is critical for viral entry,budding,production,and induction of pathology which makes it a potential target for therapeutics against COVID-19.Here,we find that the E3 ligase RNF5 interacts with and catalyzes ubiquitination of E on the 63rd lysine,leading to its degradation by the ubiquitin-proteasome system(UPS).Importantly,RNF5-induced degradation of E inhibits SARS-CoV-2 replication and the RNF5 pharmacological activator Analog-1 alleviates disease development in a mouse infection model.We also found that RNF5 is distinctively expressed in different age groups and in patients displaying different disease severity,which may be exploited as a prognostic marker for COVID-19.Furthermore,RNF5 recognized the E protein from various SARS-CoV-2 strains and SARS-CoV,suggesting that targeting RNF5 is a broad-spectrum antiviral strategy.Our findings provide novel insights into the role of UPS in antagonizing SARS-CoV-2 replication,which opens new avenues for therapeutic intervention to combat the COVID-19 pandemic. | Zhaolong Li Pengfei Hao Zhilei Zhao Wenying Gao Chen Huan Letian Li Xiang Chen Hong Wang Ningyi Jin Zhao-Qing Luo Chang Li Wenyan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
| 4 | Correction To:The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation显示文摘Correction to:Signal Transduction and Targeted Therapy http://gffzzd3cc09b8251d45dfswxb66oc955ov6fun.ffgz.tsg.suse.edu.cn/10.1038/s41392-023-01335-5,published online 03 February 2023 In the process of collating the raw data,the authors noticed 7 inadvertent mistakes occurred in Figs.3a,3b,3e,5d,6b,6d and 6e that need to be corrected after online publication of the article.1 The correct data are provided as follows.The key findings of the article are not affected by these corrections.The original article has been corrected. | Zhaolong Li Pengfei Hao Zhilei Zhao Wenying Gao Chen Huan Letian Li Xiang Chen Hong Wang Ningyi Jin Zhao-Qing Luo Chang Li Wenyan Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
| 5 | A micro-sized vaccine based on recombinant Lactiplantibacillus plantarum fights against SARS-CoV-2 infection via intranasal immunization显示文摘COVID-19 has globally spread to burden the medical system.Even with a massive vaccination,a mucosal vaccine offering more comprehensive and convenient protection is imminent.Here,a micro-sized vaccine based on recombinant Lactiplantibacillus plantarum(rLP)displaying spike or receptor-binding domain(RBD)was characterized as microparticles,and its safety and protective effects against SARS-CoV-2 were evaluated.We found a 66.7%mortality reduction and 100%protection with rLP against SARS-CoV-2 in a mouse model.The histological analysis showed decreased hemorrhage symptoms and increased leukocyte infiltration in the lung.Especially,rLP:RBD significantly decreased pulmonary viral loads.For the first time,our study provides a L.plantarum-vectored vaccine to prevent COVID-19 progress and transmission via intranasal vaccination. | Letian Li Jiayi Hao Yuhang Jiang Pengfei Hao Yuwei Gao Jing Chen Guoqing Zhang Ningyi Jin Maopeng Wang Chang Li | 2023 | Acta Pharmaceutica Sinica B2023，13，7： | 0 |
| 6 | Transmembrane domain of IFITM3 is responsible for its interaction with influenza virus HA_(2) subunit显示文摘Interferon-inducible transmembrane protein 3(IFITM3)inhibits influenza virus infection by blocking viral membrane fusion,but the exact mechanism remains elusive.Here,we investigated the function and key region of IFITM3 in blocking influenza virus entry mediated by hemagglutinin(HA).The restriction of IFITM3 on HAmediated viral entry was confirmed by pseudovirus harboring HA protein from H5 and H7 influenza viruses.Subcellular co-localization and immunocoprecipitation analyses revealed that IFITM3 partially co-located with the full-length HA protein and could directly interact with HA_(2) subunit but not HA_(1) subunit of H5 and H7 virus.Truncated analyses showed that the transmembrane domain of the IFITM3 and HA_(2) subunit might play an important role in their interaction.Finally,this interaction of IFITM3 was also verified with HA_(2) subunits from other subtypes of influenza A virus and influenza B virus.Overall,our data demonstrate for the first time a direct interaction between IFITM3 and influenza HA protein via the transmembrane domain,providing a new perspective for further exploring the biological significance of IFITM3 restriction on influenza virus infection or HA-mediated antagonism or escape. | Wang Xu Yuhang Wang Letian Li Xiaoyun Qu Quan Liu Tiyuan Li Shipin Wu Ming Liao Ningyi Jin Shouwen Du Chang Li | 2022 | Virologica Sinica2022，37，5： | 0 |
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