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| 1 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 2 | Outcome of multimodal MRI-guided intravenous thrombolysis in patients with stroke with unknown time of onset显示文摘Objective Intravenous tissue plasminogen activator(tPA)is the standard therapy for patients with acute ischaemic stroke(AIS)within 4.5 hours of onset.Recent trials have expanded the endovascular treatment window to 24 hours.We investigated the efficacy and safety of using multimodal MRI to guide intravenous tPA treatment for patients with AIS of unknown time of onset(UTO).Methods Data on patients with AIS with UTO and within 4.5 hours of onset were reviewed.Data elements collected and analysed included:demographics,National Institutes of Health Stroke Scale(NIHSS)score at baseline and 2 hours,24 hours,7 days after thrombolysis and before discharge,the modified Rankin Scale(mRS)score at 3 months after discharge,imaging findings and any adverse event.results Forty-two patients with UTO and 62 in control group treated within 4.5 hours of onset were treated with intravenous tPA.The NIHSS scores after thrombolysis and/or before discharge in UTO group were significantly improved compared with the baseline(p<0.05).Between the two groups,no significant differences in NIHSS score were observed(p>0.05).Utilising the non-inferiority test,to compare mRS scores(0-2)at 3 months between the two groups,the difference was 5.2%(92%CI,OR 0.196).Patients in the UTO group had mRS scores of 0-2,which were non-inferior to the control group.Their incidence of adverse events was similar.Conclusions Utilising multimodal MRI to guide intravenous only thrombolysis for patients with AIS with UTO was safe and effective.In those patients with AIS between 6 and 24 hours of time of onset but without large arterial occlusion,intravenous thrombolysis could be considered an option. | Jie Zhao Hongmei Zhao Runtao Li Jiangtao Li Chang Liu Juan Lv Yanan Li Wei Liu Dongpu Ma Huaihai Hao Xinguang Xiao Junzhong Liu Yongfeng Yin Rongli Liu Qiaoyan Yu Yingjie Wei Pengyan Li Yue Wang Runqing Wang | 2019 | Stroke & Vascular Neurology2019，4，1： | 8 |
| 3 | Purification of starch and phosphorus wastewater using core-shell magnetic seeds prepared by sulfated roasting显示文摘Core-shell magnetic seeds with certain adsorption capacity that were prepared by sulfated roasting, served as the core of a magnetic separation technology for purification of starch wastewater. XRD and SEM results indicate that magnetite's surface transformed to be porous α-Fe_2O_3 structure. Compared with magnetite particles, the specific surface area was significantly improved to be 8.361 from 2.591 m^2/g, with little decrease in specific susceptibility. Zeta potential, FT-IR and XPS experiments indicate that both phosphate and starch adsorbed on the surface of the core-shell magnetic seeds by chemical adsorption, which fits well with the Langmuir adsorption model. The porous surface structure of magnetic seeds significantly contributes to the adsorption of phosphate and starch species, which can be efficiently removed to be 1.51 mg/L(phosphate) and 9.51 mg/L(starch) using magnetic separation. | Chunjie Du Jinsheng Yu Wei Sun Haisheng Han Yuehua Hu Pan Chen Panpan Hou Runqing Liu Li Wang Yue Yang Ruohua Liu Lei Sun | 2019 | Journal of Environmental Sciences2019，31，7： | 4 |
| 4 | Effectiveness of intravenous r- tPA versus UK for acute ischaemic stroke: a nationwide prospective Chinese registry study显示文摘Background Intravenous recombinant tissue plasminogen activator(r-tPA)and urokinase(UK)are both recommended for the treatment of acute ischaemic stroke(AIS)in China,but with few comparative outcome data being available.We aimed to compare the outcomes of these two thrombolytic agents for the treatment of patients within 4.5 hours of onset of AIS in routine clinical practice in China.Methods A pre-planned,prospective,nationwide,multicentre,real-world registry of consecutive patients with AIS(age≥18 years)who received r-tPA or UK within 4.5 hours of symptom onset according to local decision-making and guideline recommendations during 2017-2019.The primary effectiveness outcome was the proportion of patients with an excellent functional outcome(defined by modified Rankin scale scores 0 to 1)at 90 days.The key safety endpoint was symptomatic intracranial haemorrhage according to standard definitions.Multivariable logistic regression was used for comparative analysis,with adjustment according to propensity scores to ensure balance in baseline characteristics.Results Overall,4130 patients with AIS were registered but 320 had incomplete or missing data,leaving 3810 with available data for analysis of whom 2666 received r-tPA(median dose 0.88(IQR 0.78-0.90)mg/kg)and 1144 received UK(1.71(1.43-2.00)×104 international unit per kilogram).There were several significant intergroup differences in patient characteristics:r-tPA patients were more educated,had less history of stroke,lower systolic blood pressure,greater neurological impairment and shorter treatment times from symptom onset than UK patients.However,in adjusted analysis,the frequency of excellent outcome(OR 1.18,95%CI 1.00 to 1.40,p=0.052)and symptomatic intracranial haemorrhage(OR 0.70,95%CI 0.33 to 1.47,p=0.344)were similar between groups.Conclusions UK may be as effective and carry a similar safety profile as r-tPA in treating mild to moderate AIS within guidelines in China.Registration http://gffzzd5593dd32ed44506hkkfu6npbkqu96buc.ffgz.tsg.suse.edu.cn identifier:NCT02854592. | Xinhong Wang Xiaoqiu Li Yuming Xu Runhui Li Qingcheng Yang Yong Zhao Fengyun Wang Baoying Sheng Runqing Wang Shaoyuan Chen Lihua Wang Liying Shen Xiaowen Hou Yu Cui Duolao Wang Bin Peng Craig S Anderson Huisheng Chen On behalf of INTRECIS Investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 2 |
| 5 | Assessment of sustainable energy potential of non-plantation biomass resources in China显示文摘 | Li Junfeng Hu Runqing Song Yanqing | 2005 | Biomass and Bioenergy2005，29，： | 1 |
| 6 | Sustainable biomass production for energy in China显示文摘 | LI JUNFENG HU RUNQING | 2003 | Biomass and Bioenergy2003，25，： | 1 |
| 7 | Assessment of sustainable energy Potential of Non plantation biomass resources in China显示文摘 | Li Junfeng Hu Runqing Song Yanqin | 2005 | Biomass and Bioenergy2005，29，3： | 1 |
| 8 | Residual life predictions for ball bearings based on self-organizing map and back propagation neural network methods显示文摘 | Lifeng Xia Xinglin Li | 2007 | Mechanical Systems and Signal Processing2007，，21： | 1 |
| 9 | Sustainable biomass production for energy in China 显示文摘 | Li Junfeng Hu Runqing | 2003 | Biomass and Bioenergy2003，，25： | 1 |
| 10 | Assessment of sustainable energy potential of non-plantation biomass resources in China显示文摘 | Li Junfeng Hu Runqing Song yanqin | 2005 | Biomass and Bioenergy2005，29，3： | 1 |
| 11 | Assessment of sustainable energy potential of non-plantation biomass resources inChina显示文摘 | Li Junfeng Hu Runqing Song Yanqin | 2005 | Biomass and Bioenergy2005，29，3： | 1 |
| 12 | Residual life predic- tions for ball bearings based on self-organizing map and back propagation neural network methods 显示文摘 | Huang Runqing Xi Lifeng Li Xinglin | 2007 | Mechanical Systems and Signal Processing2007，21，1： | 1 |
| 13 | Residual life predictions for ball bearings based on self organizing map and back propagation neural network methods 显示文摘 | HUANG Runqing XIA Lifeng LI Xinglin | 2007 | Mechanical Systems and Signal Processing2007，，21： | 1 |
| 14 | Assessment of Sustainable Energy Potential of Non Plantation Biomass Resources in China显示文摘 | Li Junfeng Hu Runqing Song Yanqin | 2005 | Biomass and Bioenergy2005，29，3： | 1 |
| 15 | Residual life predictions for ball bearings based on self-organizing map and back propagation neural network methods显示文摘 | Runqing Huang Lifeng Xi Xinglin Li | 2007 | Mechanical Systems and Signal Process- ing2007，21，： | 1 |
| 16 | Sustainable biomass production for energy in China显示文摘 | Li Junfeng Hu Runqing | 2003 | Biomass and Bioenergy2003，，25： | 1 |
| 17 | Residual life predictions for ball bearings based on self-organizing map and back propagation neural network methods显示文摘 | HUANG Runqing XI Lifeng LI Xinglin | 2007 | Mechanical Systems and Signal Processing2007，21，1： | 1 |
| 18 | Residual life predictions for ball bearings based on self-organizing map and back propagation neural network methods 显示文摘 | Huang Runqing Xia Lifeng Li Xinglin | 2007 | Mechanical Systems and Signal Processing2007，，21： | 1 |
| 19 | Sustainable Biomass Production for Energy in China 显示文摘 | Li Junfeng Hu Runqing | 2003 | Biomass and Bioenergy2003，25，： | 1 |
| 20 | Correlation between growth parameter of spoilage microorganisms and shelf-life of pork stored under air and modified atmosphere at -2, 4 and 10 C显示文摘 | LIU Fang YANG Runqing LI Yunfei | 2006 | Food Microbiology2006，23，： | 1 |
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