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| 1 | Clinical phenotype network: the underlying mechanism for perso- nalized diagnosis and treatment of traditional Chinese medicine显示文摘繁体中文药(TCM ) 在个性化的药的一个典型纲要调查临床的诊断和治疗整齐,它意味着有一样的疾病的个性化的病人将从不同 TCM 医生获得不同诊断和最佳的治疗。这个原则被 TCM 临床的专业人员认出并且粘住几千年了。然而,个性化的药不是的 TCM 的内在的机制到目前为止充分调查了并且仍然保持未知。这份报纸讨论 TCM 的框架在经典文学并且在真实世界的临床的背景的个性化的药,并且调查 TCM 的内在的机制从网络药的观点的个性化的药。在失眠上基于 246 个设计得好的门诊病人记录,由评估表明观察的个人偏爱和植物药方的偏爱,我们注意了每张植物药方的重要类似和每相遇的症状类似。为了调查 TCM 的内在的机制,个性化药,我们构造了一个临床的显型网络(CPN ) ,在哪个临床的显型实体喜欢症状并且诊断作为连接表现为在这些实体之间的节点和关联。这 CPN 被用来调查症候群和症状的同现的混杂的边界。小世界的拓扑的特征与高聚类结构在 CPN 被注意,它在 TCM 的合理性上提供卓见个性化的诊断和处理。这个网络上的调查将帮助我们在 TCM 的内在的机制上获得理解个性化的药并且将为 TCM 的精炼建议一个新观点个性化的临床的技巧。 | Xuezhong Zhou Yubing Li Yonghong Peng Jingqing HU Runshun Zhang Liyun He Yinghui Wang Lijie Jiang Shiyan Yan Peng Li Qi Xie Baoyan Liu | 2014 | Frontiers of Medicine2014，8，3： | 7 |
| 2 | Multistage analysis method for detection of effective herb prescription from clinical data显示文摘为特定的疾病条件或特别的耐心的组决定有效繁体中文药(TCM ) 治疗是因为复杂个性化的表明,在真实世界的病人和在临床的背景规定的个性化的联合治疗要求调查的一个困难的问题。在这研究,集成倾向大小写匹配的一个多级式的分析方法,复杂网络分析,和植物给了丰富分析被建议为特别疾病识别有效植物药方(例如,失眠) 。首先,匹配的倾向大小写被使用匹配临床的盒子。然后,核心网络抽取和植物集合丰富被联合检测核心有效植物药方。基于有效性的相互的信息被用来检测强壮的 herbsymptom 关系。这个方法在一个 TCM 临床的数据集合上被使用, 955 个病人从设计得好的观察研究收集了。结果与更高的有效性率揭示了那组植物药方(76.9% 对 42.8% 为匹配的样品;94.2% 对 84.9% 为所有样品) 与原版相比,药方被发现。有症状表明的特别的耐心的组也被识别帮助调查有效植物药方的指示。 | Kuo Yang Runshun Zhang Liyun He Yubing Li Wenwen Liu Changhe Yu Yanhong Zhang Xinlong Li Yan Liu Weiming Xu Xuezhong Zhou Baoyan Liu | 2018 | Frontiers of Medicine2018，12，2： | 5 |
| 3 | Hybrid interference alignment and power allocation for multi-user interference MIMO channels显示文摘This paper proposes a hybrid interference alignment scheme which combines maximizing signal-toleakage-noise ratio(Max-SLNR) at transmitter and maximizing signal-to-interference-noise ratio(Max-SINR) at receiver.The proposed scheme gives the same sum rate as the existing method using Max-SINR at both transmitter and receiver by avoiding the operation of reversing channel,thus it provides a simpler solution.Furthermore,two power allocation procedures are devised based on game theory and water filling.The gain of these schemes over equal power allocation increases to 2 bit/s/Hz in correlated fading channels as large-scale fading becomes significant.Additionally,user fairness is solved by introducing weighting factors. | SHU Feng YOU XiaoHu WANG Mao HAN YuBing LI Yang SHENG WeiXing | 2013 | Science China(Information Sciences)2013，56，4： | 5 |
| 4 | Predictions of mortality related to four major cancers in China,2020 to 2030显示文摘Background:Cancer has become a global health problem,and assessments of cancer mortality are important for effective public health policy-making and adequate resource allocation.In this study,we aimed to predict the mortality rates and numbers of deaths related to four common cancers(lung,liver,stomach,and esophagus)in China from 2020 to 2030 and to estimate the corresponding cancer burden caused by population aging and tobacco smoking.Methods:Cancer mortality data(2004-2017)were extracted from China’s death surveillance datasets,and China’s population figures(2020-2030)were obtained from the United Nations population projections.Smoking prevalence data were retrieved from a World Health Organization global report,and relative risks of smoking and cancers were derived from large-scale Asian studies.We predicted the deaths related to the four major cancers and age-standardized mortality rates using joinpoint regression and linear regression models.The tobacco smoking related burden of these four major cancers was estimated using the population attributable fraction.Results:Unlike lung cancer mortality which was predicted to continue to increase,the age-standardized mortality rates for digestive cancers(liver,stomach,and esophageal cancers)are predicted to decline over the next decade.The number of deaths caused by the four major cancers is predicted to increase from 1,490,304 in 2020 to 1,823,960 in 2030.The age-specific mortality rates of the four major cancers are predicted to increase with age after 40-45 years,peaking in the age groups of 80-84 and ≥85 years.In 2030,the combined number of deaths from the four examined cancers among adults aged ≥65 years is predicted to be 1,167,153,accounting for 64% of all deaths from these cancers.Tobacco smoking is predicted to contribute to nearly 29% of deaths fromthese cancers,corresponding to 527,577 deaths.Conclusions:The overall trend in the combined total mortality from four major cancers is predicted to decline over the next decade;however,the corresponding death toll is expected to surge,in the context of China’s population aging and high smoking prevalence.These estimates provide data-driven evidence for China to implement effective cancer control measures in the future. | Ning Li Peng Wu Yubing Shen Cuihong Yang Luwen Zhang Yali Chen Zixing Wang Jingmei Jiang | 2021 | Cancer Communications2021，41，5： | 4 |
| 5 | Multiple resonances with time delays in scale-free networks of Hodgkin-Huxley neurons subjected to non-Gaussian noise显示文摘The spiking behavior with varying time delay in scale-free networks of Hodgkin-Huxley neurons with non-Gaussian noise has been studied,and the effect of non-Gaussian noise on the delay-induced spiking behavior is discussed. It was found that multiple spatio-temporal resonances occur when the delay lengths are integer multiples of the spiking periods,and the resonances may be strengthened when the non-Gaussian noise is appropriate. This result shows that time delays can optimize the spiking temporal regularity and spatial synchronization,and appropriate non-Gaussian noise may enhance the delay-induced spiking behaviors. Our findings may help to further understand the joint roles of non-Gaussian noise and time delays in the spiking activity of scale-free neuronal networks. | HAO YingHang GONG YuBing LIN Xiu WANG Li | 2011 | Science China Chemistry2011，54，5： | 2 |
| 6 | Simple and efficient delivery of cellimpermeable organic fluorescent probes into live cells for live-cell superresolution imaging显示文摘Numerous commercial organic fluorophores with excellent optical properties are precluded from live-cell superresolution imaging due to poor cell permeability.Here,we develop a simple but effective strategy that renders cells permeable to cell-impermeable,organic fluorescent probes by using a novel peptide vehicle,PV-1.By simple coincubation with PV-1,22 different cell-impermeable,organic fluorescent probes were efficiently delivered into live cells and specifically labeled a variety of organelles.Moreover,PV-1 can simultaneously transfer up to three different probes into live cells.By using PV-1 and these cell-impermeable fluorescent probes,we obtained multicolor,longterm,live-cell superresolution images of various organelles,which allowed us to study the dynamic interactions between them.PV-1,together with these organic fluorescent probes,will greatly broaden the applications of superresolution imaging technology in diverse live-cell studies and opens up a new avenue in the design and application of peptide vehicles. | Meng Zhang Meihua Li Wenting Zhang Yubing Han Yu-Hui Zhang | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 7 | Application of non-equilibrium dendrite growth model considering thermo-kinetic correlation in twin-roll casting显示文摘Upon non-equilibrium solidifications, dendrite growth, generally as precursor of as-solidified structures,has severe effects on subsequent phase transformations. Considering synergy of thermodynamics and kinetics controlling interface migration and following conservation of heat flux in solid temperature field, a more flexible modeling for the dendrite growth is herein developed for multi-component alloys,where, two inherent problems, i.e. correlation between thermodynamics and kinetics(i.e. the thermokinetic correlation), and theoretical connection between dendrite growth model and practical processing,have been successfully solved. Accordingly, both the thermodynamic driving force G and the effective kinetic energy barrier Qeffhave been found to control quantitatively the dendrite growth(i.e. especially the growth velocity, V), as reflected by the thermo-kinetic trade-off. Compared with previous models, it is the thermo-kinetic correlation that guarantees quantitative connection between the practical processing parameters and the current theoretical framework, as well as more reasonable description for kinetic behaviors involved. Applied to the vertical twin-roll casting(VTC), the present model, realizes a good prediction for kissing points, which influences significantly alloy design and processing optimization.This work deduces quantitatively the thermo-kinetic correlation controlling the dendrite growth, and by proposing the parameter-triplets(i.e. G-Qeff-V), further opens a new beginning for connecting solidification theories with industrial applications, such as the VTC. | Yubing Zhang Jinglian Du Kang Wang Huiyuan Wang Shu Li Feng Liu | 2020 | Journal of Materials Science & Technology2020，44，9： | 2 |
| 8 | Chemical synaptic coupling-induced delay-dependent synchronization transitions in scale-free neuronal networks显示文摘Chemical synaptic couplings are more common than electric(gap junction) connections in neurons.In this paper,the firing synchronizations induced by chemical synaptic coupling in chemically delayed scale-free networks of modified Hodgkin-Huxley neurons have been studied.It was found that the chemical coupling-induced synchronization transitions are delay-dependent and much different for various delay lengths.In the absence of delay,the neurons exhibit a transition from chaotic bursting(CB) to bursting synchronization(BS) with desynchronized spikes in each burst;for smaller delay lengths,the firing evolves from CB to spiking synchronization(SS),but for larger delay lengths,there are transitions from CB to intermittently multiple SS behaviors.These findings show that the chemical coupling-induced firing synchronization transitions strongly depend on the chemical delay lengths,and intermittently multiple SS can only occur for larger delay lengths.This result would be helpful for better understanding the joint roles of the chemical coupling and chemical delay in the firing activity of the neurons. | GONG YuBing LIN Xiu WANG Li HAO YingHang | 2011 | Science China Chemistry2011，54，9： | 2 |
| 9 | Comparative studies on leaf epidermal micromorphology and mesophyll structure of Elaeagnus angustifolia L.in two different regions of desert habitat显示文摘In order to obtain qualitative and quantitative characteristics of leaf epidermal micromorphology and mesophyll structure to evaluate the responses of Elaeagnus angustifolia L.to different environmental factors,epidermal micromorphology was observed by scanning electron microscopy(SEM),and mesophyll structure was studied by light microscopy(LM) and transmission electron microscopy(TEM).Materials were selected from Linze County,Gansu Province(material A) and Qitai County,Xinjiang Uygur Autonomous Region(material B) of China.Results show that lamina thickness was higher in material A,with one layer of epidermal cells in both adaxial and abaxial surfaces,and epidermal cell radial length was significantly longer in the adaxial surface.E.angustifolia leaves are typically bifacial,with a higher ratio of palisade to spongy tissue in material A.The thickness of trichome layer of epidermis was thicker in material A.In contrast,cell wall and cuticular wax of the epidermal cells were thinner in material A than in material B.Chloroplast ultrastructure was different with the approximate spherical chloroplast containing numerous starch grains and osmiophilic granules in material A,while only the spindly chloroplast contained starch grains in material B.Multiple layers of peltate or stellate-peltate trichomes occupied both leaf surfaces in material A and the abaxial surface in material B,while the adaxial surface of material B contained few trichomes.Stomata were not observed on the leaf surfaces in materials A and B by SEM because of trichome obstruction.Our results indicate that the leaf structure of E.angustifolia is closely correlated with environmental factors,and the combination of leaf epidermal micromorphology and mesophyll structure afford resistance to environmental stress. | MengMeng Li YuBing Liu MeiLing Liu Dan Liu | 2015 | Research in Cold and Arid Regions2015，7，3： | 2 |
| 10 | Plant base editing and prime editing:The current status and future perspectives显示文摘Precise replacement of an allele with an elite allele controlling an important agronomic trait in a predefined manner by gene editing technologies is highly desirable in crop improvement.Base editing and prime editing are two newly developed precision gene editing systems which can introduce the substitution of a single base and install the desired short indels to the target loci in the absence of double-strand breaks and donor repair templates,respectively.Since their discoveries,various strategies have been attempted to optimize both base editor(BE)and prime editor(PE)in order to improve the precise editing efficacy,specificity,and expand the targeting scopes.Here,we summarize the latest development of various BEs and PEs,as well as their applications in plants.Based on these progresses,we recommend the appropriate BEs and PEs for both basic plant research and crop improvement.Moreover,we propose the perspectives for further optimization of these two editors.We envision that both BEs and PEs will become the routine and customized precise gene editing tools for both plant biological research and crop improvement in the near future. | Jingying Li Chen Zhang Yubing He Shaoya Li Lei Yan Yucai Li Ziwei Zhu Lanqin Xia | 2023 | Journal of Integrative Plant Biology2023，65，2： | 1 |
| 11 | Erratum to: Bimetallic clusters confined inside silicalite-1 for stable propane dehydrogenation显示文摘Erratum to Nano Research,2023,16(8):10881–10889 http://gffzzd3cc09b8251d45dfsw590pbovnf956w0o.ffgz.tsg.suse.edu.cn/10.1007/s12274-023-5953-y The equal contribution symbols were unfortunately missing.Instead of Xueer Wei1,Jiawei Cheng1,Yubing Li1,Kang Cheng1,2(✉),Fanfei Sun3,4(✉),Qinghong Zhang1(✉),and Ye Wang1,21 State Key Laboratory of Physical Chemistry of Solid Surfaces,Collaborative Innovation Center of Chemistry for Energy Materials,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,China 2 Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM),Xiamen 361005,China 3 Shanghai Synchrotron Radiation Facility,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai 201800,China 4 Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201204,China. | Xueer Wei Jiawei Cheng Yubing Li Kang Cheng Fanfei Sun Qinghong Zhang Ye Wang | 2024 | Nano Research2024，17，4： | 1 |
| 12 | Efficient silencing of the multicopy DUX4 gene by ABE-mediated start codon mutation in human embryos显示文摘The Dux gene plays an important role in mouse embryo development(De Iaco et al.,2017;Hendrickson et al.,2017;Whiddon et al.,2017).It participates in the maternal-to-zygotic transition(MTZ),which mainly includes maternal transcript degradation and zygotic genome activation(ZGA)and is the key process for embryonic development.Approximately 11-100 copies of the DUX4 gene form a tandem cluster in the human genome(Snider et al.,2009,2010). | Yubing Liu Xinmei Lu Min Ye Ling Wang Rongxin Tang Zhiyong Yang Bongkoch Turathum Chenchen Liu Yujing Xue Menghua Wu Yannan Yang Ermeng Gao Di Zhang Feng Yang Keh-Kooi Kee Xingxu Huang Guanglei Li Ri-Cheng Chian | 2022 | Journal of Genetics and Genomics2022，49，10： | 1 |
| 13 | Preparation and antioxidant activity of albumin binding Salen Schiff-base metal complexes显示文摘A kind of novel biopolymer antioxidant (BSA/HOSalenM, M=Co, Mn, Zn) is prepared with conjugation, which increases the antioxidant activity of the bovine serum albumin (BSA). The conjugations have been characterized by IR spectra, UV-Vis spectra, Fluorescence spectra, Circular dichroism (CD) spectra and Native-PAGE. The BSA is used as a biopolymer scaffold, and the insoluble Salen Schiff-base metal complexes HOSalenM make axial coordination with the amino acid residues of the BSA. The structure of the BSA is unchanged when the binding rate of HOSalenCo is less than 10. The HOSalenCo conjugations show an excellent hydroxyl radical (·OH) scavenging activity, and the activity (EC50 ) of BSA/HOSalenCo(10) (BSA : HOSalenCo=1 : 10) is improved by two orders of magnitude compared with the BSA, while the activity of the BSA/HOSalenMn is weak and the BSA/HOSalenZn shows no scavenging activity. | LI Gang ZHANG HuiFang WANG RongMin HE YuFeng XIONG YuBing | 2013 | Chinese Science Bulletin2013，58，24： | 1 |
| 14 | Dual-modulation difference stimulated emission depletion microscopy to suppress the background signal显示文摘Stimulated emission depletion(STED)nanoscopy is one of the most well-developed nanoscopy techniques that can provide subdiffraction spatial resolution imaging.Here,we introduce dual-modulation difference STED microscopy(dmdSTED)to suppress the background noise in traditional STED imaging.By applying respective time-domain modulations to the two continuous-wave lasers,signals are distributed discretely in the frequency spectrum and thus are obtained through lock-in demodulation of the corresponding frequencies.The background signals can be selectively eliminated from the effective signal without compromise of temporal resolution.We used nanoparticle,fixed cell,and perovskite coating experiments,as well as theoretical demonstration,to confirm the effectiveness of this method.We highlight dmdSTED as an idea and approach with simple implementation for improving the imaging quality,which substantially enlarges the versatility of STED nanoscopy. | Wensheng Wang Chuankang Li Zhengyi Zhan Zhimin Zhang Yubing Han Cuifang Kuang Xu Liu | 2022 | Advanced Photonics2022，4，4： | 1 |
| 15 | Ammonia-induced energy disorders interfere with bilirubin metabolism in hepatocytes显示文摘 | Qiongye Wang Yanfang Wang Zujiang Yu Duolu Li Bin Jia Jiangjing Li Kelei Guan Yubing Zhou Yanling Chen Quancheng Kan | 2014 | Archives of Biochemistry and Biophysics2014，，： | 1 |
| 16 | Advances in wide-tuning and narrow-linewidth external-cavity diode lasers显示文摘The external-cavity diode laser is advantageous in terms of low noise,high side-mode suppression ratio,high temperature stability,simple structure,and low cost,which has been the preferred scheme to realize wide-tuning and narrow-linewidth characteristics.Thus,it has been widely used in optical communication,lidar,environmental monitoring,spectral analysis,optical coherence tomography,and other frontier fields.Herein,we introduce the technical scheme and review the development status of wide-tuning and narrow-linewidth external-cavity diode lasers in detail.Primarily,the structure,working principles,and performance characteristics of external-cavity diode lasers are deeply analyzed according to different structures.The structural characteristics,key technologies,optical performance and application fields of state-of-theart studies in recent years are discussed.Finally,the challenges and potential development prospects of wide-tuning and narrow-linewidth external-cavity diode lasers are analyzed and discussed. | Qiang CUI Yuxin LEI Yongyi CHEN Cheng QIU Ye WANG Dexiao ZHANG Lutai FAN Yue SONG Peng JIA Lei LIANG Yubing WANG Li QIN Yongqiang NING Lijun WANG | 2022 | Science China(Information Sciences)2022，65，8： | 1 |
| 17 | Pixel level image fusion algorithm based on PCA显示文摘 | Li Mingjing Dong Yubing Li Jie | 2014 | Applied Mechanics and Materials2014，，： | 1 |
| 18 | Recent development of nanomaterials for carbon dioxide electroreduction显示文摘Electrochemical CO_(2) reduction reaction(CO_(2)RR)to produce value‐added products has received tremendous research attention in recent years.With research efforts across the globe,remarkable advancement has been achieved,including the improvement of selectivity for the reduction products,the realization of efficient reduction beyond two electrons,and the delivery of industrially relevant current densities.In this review,we introduce the recent development of nanomaterials for CO_(2)RR,including the zero‐dimensional graphene quantum dots,two‐dimensional materials such as metal chalcogenides and metal/covalent organic framework,singleatom catalysts,and nanostructured metal catalysts.The engineering of materials into three‐dimensional structure will also be discussed.Finally,we will provide a summary of the catalytic performance and perspectives on future development. | Jianjun Su Yong Liu Yun Song Libei Huang Weihua Guo Xiaohu Cao Yubing Dou Le Cheng Geng Li Qiushi Hu Ruquan Ye | 2022 | SmartMat2022，3，1： | 1 |
| 19 | Advances in narrow linewidth diode lasers显示文摘The smart travel era has come and requirement for high precision lidar detection technology is higher and higher. The new solid-state lidars can meet the requirements of intelligent cars in the future, with the advantages of high resolution, strong anti-active jamming ability, small volume, light weight, low cost and so on. The narrow linewidth diode laser is the perfect light source of solid-state lidars. The progress and development of narrow linewidth diode laser technique can greatly improve the application of solidstate lidar. The technology and development status of narrow linewidth diode lasers has been described detailly in the paper. And the design ideas, key fabrication technologies and optical characteristics of various narrow linewidth diode lasers have been analyzed and discussed as well. Finally, the developments of narrow linewidth diode lasers are prospected. | Xingkai LANG Peng JIA Yongyi CHEN Li QIN Lei LIANG Chao CHEN Yubing WANG Xiaonan SHAN Yongqiang NING Lijun WANG | 2019 | Science China(Information Sciences)2019，62，6： | 1 |
| 20 | Generalized stability criterion for controlling solidification segregation upon twin-roll casting显示文摘Macro-and micro-segregation formed upon twin-roll casting(TRC)can be inherited from sub-rapid solid-ification to solid-state transformation,even to plastic deformation,thus deteriorating drastically mechan-ical properties of as-produced thin sheets.Although many works focusing mainly on controlling fields of thermal,concentration and convection have been reported,how to control artificially and quantitatively the segregation using a theoretical connection between processing parameters and solidification models,has not been realized,yet.Regarding it,a systematical framework integrating non-equilibrium dendritic growth and overall solidification kinetics with the TRC parameters,was constructed applying a general-ized stability(GS)conception deduced from transient thermodynamic driving force△G^(t)and transient ki-netic energy barrier Q_(eff)^(t)evolving upon solidification.Departing from this framework considering synergy of thermodynamics and kinetics(i.e.,thermo-kinetic synergy),a criterion of high△G^(t)-high GS guaranteed that the macro(i.e.,the centerline)and the micro(i.e.,the edge)segregation can be suppressed by in-creasing△G^(t)and GS at the beginning and the ending stage of sub-rapid solidification,respectively.This typical thermo-kinetic combination producing the microstructure can be inherited into the plastic de-formation,as reflected by corresponding strength-ductility combinations.This work realized quantitative controlling of TRC by a theoretical connection between processing parameters and solidification models,where,an optimization for sub-rapid solidification segregation using the GS conception including△G^(t)and Q_(eff)^(t)has been performed. | Pan Wu Yubing Zhang Jiaqi Hu Shaojie Song Yong Li Huiyuan Wang Guo Yuan Zhaodong Wang Shizhong Wei Feng Liu | 2023 | Journal of Materials Science & Technology2023，，3： | 1 |
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