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| 1 | Artemisinin, the Magic Drug Discovered from Traditional Chinese Medicine显示文摘Artemisinin and its derivatives represent the most important and influential class of drugs in the fight against malaria. Since the discovery of artemisinin in the early 1970s, the global community has made great strides in characterizing and understanding this remarkable phytochemical and its unique chemical and pharmacological properties. Today, even as artemisinin continues to serve as the foundation for antimalarial therapy, numerous challenges have surfaced in the continued application and development of this family of drugs. These challenges include the emergence of delayed treatment responses to artemisinins in malaria and efforts to apply artemisinins for non-malarial indications. Here, we provide an overview of the story of artemisinin in terms of its past, present, and future. In particular, we comment on the current understanding of the mechanism of action (MOA) of artemisinins, and emphasize the importance of relating mechanistic studies to therapeutic outcomes, both in malarial and non-malarial contexts. | Jigang Wang Chengchao Xu Yin Kwan Wong Yujie Li Fulong Liao Tingliang Jiang Youyou Tu | 2019 | Engineering2019，5，1： | 16 |
| 2 | Flow behavior of liquid metal in the connected fascial space: Intervaginal space injection in the rat wrist and mice with tumor显示文摘扁带和 fascial 空格能帮助提供天体的更好的理解。intervaginal 空间注射(ISI ) 提供要求进一步的调查的唯一的优点。包括生理的条件和肿瘤过程的一个上面的手足模型被选择在 ISI 以后决定液体金属的流动行为。在正常老鼠,在直到 intervaginal 空间的液体金属的注射以后包括腱,容器,和神经,磁性的回声成像和一个解剖实验显示没有容器或淋巴节点,在 fascial 空间附近并且最后包的液体金属到达了下游的指尖和除了神经与血管的捆在上游的腋窝。用环境扫描,电子显微镜学(ESEM ) 想象,我们发现液体金属在扁带的纤维附近被包并且向前搬到 microscale 或 nanoscale 区域。这些数据证实了一条基于扁带的小径。在肿瘤,液体金属通过损坏的点搬到肿瘤囊,在癌症房间破坏在正常房间和癌症房间之间的扁带的完整的地方。部分在肿瘤附近包并且把肿瘤与包围正常肌肉分开了的液体金属。ESEM 图象证明扁带的纤维渗透了肿瘤,因此形成液体金属通过渗透了肿瘤的一个网络。我们的学习在 ISI 以后在上面的手足说明了液体金属的生理、病理学的流动行为并且在扁带表明了一条 nonvascular 小径。ISI 可能为在 fascial 小径的临床的治疗是有用的。 | Nan Hu Yupeng Cao Zhuo Ao Xinxiao Han Qiang Zhang Wentao Liu Sidi Liu Fulong Liao Dong Han | 2018 | Nano Research2018，11，4： | 5 |
| 3 | Discovery and repurposing of artemisinin显示文摘Malaria is an ancient infectious disease that threatens millions of lives globally even today.The discovery of artemisinin,inspired by traditional Chinese medicine(TCM),has brought in a paradigm shift and been recognized as the“best hope for the treatment of malaria”by World Health Organization.With its high potency and low toxicity,the wide use of artemisinin effectively treats the otherwise drug-resistant parasites and helps many countries,including China,to eventually eradicate malaria.Here,we will first review the initial discovery of artemisinin,an extraordinary journey that was in stark contrast with many drugs in western medicine.We will then discuss how artemisinin and its derivatives could be repurposed to treat cancer,inflammation,immunoregulation-related diseases,and COVID-19.Finally,we will discuss the implications of the“artemisinin story”and how that can better guide the development of TCM today.We believe that artemisinin is just a starting point and TCM will play an even bigger role in healthcare in the 21st century. | Qiaoli Shi Fei Xia Qixin Wang Fulong Liao Qiuyan Guo Chengchao Xu Jigang Wang | 2022 | Frontiers of Medicine2022，16，1： | 2 |
| 4 | Regulation of blood viscosity in disease prevention and treatment显示文摘Blood viscosity plays an important role in maintaining vascular homeostasis. Under normal physiological conditions, blood viscosity is kept at a relatively stable level by a variety of regulatory mechanisms. However, under pathological conditions, disorders in these regulatory mechanisms mediated by endothelial cell dysfunction result in the pathogenesis and development of certain diseases, such as cardio-cerebrovascular diseases, diabetes mellitus, and hemorrhagic shock. Therefore, monitoring and regulating blood viscosity are important for the diagnosis, treatment, and prognosis of disease. This article reviews the role of blood viscosity regulation and its importance in disease prevention and treatment. | CHEN Gan ZHAO Lian LIU YaoWen LIAO FuLong HAN Dong ZHOU Hong | 2012 | Chinese Science Bulletin2012，57，16： | 1 |
| 5 | Hemorheological Investigation of Clotting by Rotational Viscometer显示文摘 | LIAO Fulong LI Wen HUANG Shen | 1987 | Clinical Hemorheo-logy1987，7，： | 1 |
| 6 | A New Bemorheological Approach for Evaluation of Antiplatelet and Anticoagulative Drugs-rotational Viscometry显示文摘 | LIAO Fulong LI Wen YIN Xiaojie | 1992 | Clinical Hemorheology1992，12，： | 1 |
| 7 | New guidelines for hemorheological laboratory techniques显示文摘 | Oguz K. Baskurt Michel Boynard Giles C. Cokelet Philippe Connes Brian M. Cooke Sandro Forconi Fulong Liao Max R. Hardeman Friedrich Jung Herbert J. Meiselman Gerard Nash Norbert Nemeth Bj?rn Neu Bo Sandhagen Sehyun Shin George Thurston Jean Luc Wautier | 2009 | Clinical Hemorheology and Microcirculation2009，，： | 1 |
| 8 | Inhibition by diallyl trisulfide, a garlic component, of intracellular Ca 2+ mobilization without affecting inositol-1,4,5-trisphosphate (IP 3 ) formation in activated platelets显示文摘 | Ruomei Qi Fulong Liao Katsue Inoue Yutaka Yatomi Kaneo Sato Yukio Ozaki | 2000 | Biochemical Pharmacology2000，，10： | 1 |
| 9 | Neglected interstitial space in malaria recurrence and treatment显示文摘The interstitial space, a widespread fluid-filled compartment throughout the body, is related to many pathophysiological alterations and diseases, attracting increasing attention. The vital role of interstitial space in malaria infection and treatment has been neglected current research efforts. We confirmed the reinfection capacity of parasites sequestrated in interstitial space, which replenish the mechanism of recurrence. Malaria parasite-infected mice were treated with artemisinin-loaded liposomes through the interstitial space and exhibited a better therapeutic response. Notably, compared with oral administration, interstitial administration showed an unexpectedly high activation and recruitment of immune cells, and resulted in better clearance of sequestered parasites from organs, and enhanced pathological recovery. The interstitial route of administration prolongs the blood circulation time of artemisinin and increases its plasma concentration, and may compensate for the inefficiency of oral administration and the nanotoxicity of intravenous administration, providing a potential strategy for infectious disease therapy. | Qiang Zhang Zhuo Ao Nan Hu Yuting Zhu Fulong Liao Dong Han | 2020 | Nano Research2020，13，10： | 0 |
| 10 | Chinese medicine,flowing blood,biomechanopharmacology and future preventive medicine显示文摘Activating Blood Circulation to Remove Blood Stasis(ABCRBS) has long been the most fundamental therapeutic principle since the age of Yellow Emperor(circa 2600 BC) in Chinese medicine.Based on bio-responses of blood shear stress,which was not considered in Chinese medicine,we have initiated the merging of biomechanics with pharmacology and Chinese medicine,establishing the new discipline-biomechanopharmacology.Practice of exercise is a simple and self-regulatory way to promote shear stress in the circulation.Interestingly,acupuncture and massage are also linked with shear stress regulation.These procedures are expected to maintain normal functions of endothelial cells(ECs) by regulating shear stress levels of flowing blood.The statement of 'Diseases are prevented as blood flow is promoted' by the renowned ancient physician Huatuo,who presented the wise foresight of the efficacy of shear stress,would likely begin a new chapter in preventive pharmacology and medicine in the years to come. | HAN Dong LIAO FuLong | 2012 | Chinese Science Bulletin2012，57，27： | 0 |
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