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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | A Comprehensive Strategy to Boost the Quantum Yield of Luminescence of Europium Complexes 显示文摘 | Lima N B D Gonqalves S M C Jtnior S A | 2013 | Sci Rep2013，3，： | 1 |
| 3 | Microstructural an- alyses and wear behavior of the cemented carbide tools after laser surface treatment and PVD coating 显示文摘 | Neves D Diniz A E Lima M S F | 2013 | Ap- plied Surface Science2013，282，： | 1 |
| 4 | Secondary hyperalgesiain the monoarthritic rat is mediated by GABABand NK 1re-ceptors of spinal dorsal horn neurons:a behavior and c-fosstudy显示文摘 | Castro A R Pinto M Lima D | 2006 | Neuroscience2006，41，4： | 1 |
| 5 | Impact of genetically modified Enterobacter cloacae on indigenous endophytic community of Citrus sinensis seedlings显示文摘 | Andreote F D Gullo M J M de Souza Lima A O | 2004 | Journal of Microbiology2004，42，3： | 1 |
| 6 | The Wnt signaling pathway and rheumatoid arthritis显示文摘 | Rabelo F D da Mota L M Lima R A | 2010 | Autoimmun Rev2010，9，4： | 1 |
| 7 | Serologic marker candidates identified among B-cell linear epi- topes of Nsp2 and structural proteins of a North Ameri- can strain of porcine eproductive and respiratory syn- drome virus显示文摘 | Lima M D Pattnaik A K Flores E F | 2006 | Virology2006，353，： | 1 |
| 8 | Activity and stability of a crude lipase from penicillium a urantiogrieum in aqueous media and organic sdvents显示文摘 | LIMA V M G KRIEGER N MITCHLL D A | 2004 | Biochemical Engineering Journal2004，18，： | 1 |
| 9 | Thermal degradation of biodegradable edible films based on xanthan and starches from different sources显示文摘 | Soares R M D Lima A M F Oliveira R V B | 2005 | Polym Degrad Stab2005，4，7： | 1 |
| 10 | Luminescent properties and lattice defects correlation on zinc oxide显示文摘 | Lima S A M Sigoli F A Jafelicei M et d | 2001 | International Journal of Inorganic Materials2001，3，7： | 1 |
| 11 | Biochar: A Synthesis of Its Agronomic Impact beyond Carbon Sequestration显示文摘 | Spokas Kurt A Cantrell Keri B M Novak Jeffrey Archer David W Ippolito James A Collins Harold P Boateng Akwasi A Lima Isabel M Lamb Marshall C McAloon Andrew J Lentz Rodrick D Nichols Kristine A | 2012 | Journal of Environmental Quality2012，，4： | 1 |
| 12 | Heart rate monitoring in soccer:interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bara Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength Cond Res2012，26，10： | 1 |
| 13 | Large-scale evidence forconservation of NMD candidature across mammals显示文摘 | de Lima Morais D A Harrison P M | 2010 | PLoSONE2010，5，11： | 1 |
| 14 | Effect of a chayotte (Sechium edule) extract on the labeling of red blood cells and plasma proteins with technetium-99m: in vitro and in vivo studies显示文摘 | Feliciano G D Lima E A Pereira M J | 2002 | Cellular and Molecular Biology (Noisy-le-Grand France)2002，48，7： | 1 |
| 15 | Heart rate monitoring in soccer: interest and limits during competitive match play and training, practical applica- tion显示文摘 | Alexandre D da Silva C D Hill-Haas S Wong del P Natali A J De Lima J R Bars Filho M G Matins J J Garcia E S Karim C | 2012 | J Strength C ond Res2012，26，10： | 1 |
| 16 | Synthesis of alumina powders by the glycine-nitrate combustion process 显示文摘 | Toniolo J C Lima M D Takimi A S | 2005 | Materials Research Bulletin2005，40，： | 1 |
| 17 | Spectrophotometric Determination of Iron and Boron in Soil ExtractsUsing A Multi-syringe Flow Injection System显示文摘 | Gomes D M C Segundo M A Lima J L F C | 2005 | Talanta2005，66，： | 1 |
| 18 | Digital scalar pulse-width modulation:a simple approach to introduce non-sinusoidal modulating waveforms显示文摘 | JACOBINA C B LIMA A M da SILVA E D | 2001 | IEEE Trans on Power Electronics2001，16，3： | 1 |
| 19 | Human papillomavirus genotype attribution in invasive cervical cancer:a retrospective cross-sectional worldwide study显示文摘 | de Sanjose S Quint WG Alemany L Geraets DT Klaustermeier JE Lloveras B Tous S Felix A Bravo LE Shin HR Vallejos CS de Ruiz PA Lima MA Guimera N Clavero O Alejo M Llombart-Bosch A Cheng-Yang C Tatti SA Kasamatsu E Iljazovic E Odida M Prado R Seoud M Grce M Usubutun A Jain A Suarez GA Lombardi LE Banjo A Menéndez C Domingo EJ Velasco J Nessa A Chichareon SC Qiao YL Lerma E Garland SM Sasagawa T Ferrera A Hammouda D Mariani L Pelayo A Steiner I Oliva E Meijer CJ AlJassar WF Cruz E Wright TC Puras A Llave CL Tzardi M Agorastos T Garcia-Barriola V Clavel C Ordi J Andújar M Castellsagué X Sánchez GI Nowakowsld AM Bornstein J Mu(n)oz N Bosch FX Retrospective International Survey and HPV Time Trends Study Group | 2010 | Lancet Oncol2010，11，11： | 1 |
| 20 | Preventive control stability via neural network sensitivity 显示文摘 | Passaro M C Silva A P A D Lima A C S | 2014 | IEEE Transactions on Power Systems2014，，： | 1 |
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