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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Effects of resistance training on the lipid profile in obese women显示文摘 | Costa R R Lima Alberton C Tagliari M Martins Kruel L F | 2011 | Journal of Sports Medicine and Physical Fitness2011，，1： | 2 |
| 3 | Anionic flotation of railings of manganese ore 显示文摘 | Lima R M F Vasconcelos J A da Silva G R | 2008 | Rem-revista Escolade Minas2008，61，3： | 1 |
| 4 | ln vivo and in vitro studies on the anticancer activity of Copaifera multijuga Hayne and its fractions显示文摘 | Lima S R M Junior V F V Christo H B | 2003 | Phytotherapy Research2003，17，9： | 1 |
| 5 | Effect of combined ensiling of sorghum and soybean with or without molasses and lactobacilli on silage quality and in vitro rumen fermentation显示文摘 | Lima R Lourenco M Diaz R F | 2010 | Animal Feed Science and Technology2010，155，2： | 1 |
| 6 | Effect of source of supplemental selenium on uterine health and embryo quality in high-producing dairy cows显示文摘 | Cerri R L A Rutigliano H M Lima F S | 2009 | Theriogenology2009，71，7： | 1 |
| 7 | Hypertension in postmenopausal women显示文摘 | Lima R Wofford M Jane F | 2012 | Curr Hypertens Rep2012，14，3： | 1 |
| 8 | The Wnt signaling pathway and rheumatoid arthritis显示文摘 | Rabelo F D da Mota L M Lima R A | 2010 | Autoimmun Rev2010，9，4： | 1 |
| 9 | Spin Coater Based on Brushless DC Motor of Hard Disk Drivers显示文摘 | Bianchi R F Panssiera M F Lima J P H | 2006 | Progress in Organic Coatings2006，57，： | 1 |
| 10 | Anisotropic superconducting properties of aligned MgB2 crystallites显示文摘 | Lima O F Ribeiro R A Avila M A | 2001 | Physical Review Letters2001，86，： | 1 |
| 11 | 查看详情显示文摘 | Lima A M F de Castro V G Borges R S Silva G G | | 0，，02： | 1 |
| 12 | Sodium hyaluronate accelerates the healing process in tooth sockets of rats显示文摘 | Mendes R M Silva G A Lima M F et a1 | 2008 | Arch Oral Biol2008，53，12： | 1 |
| 13 | Thermal degradation of biodegradable edible films based on xanthan and starches from different sources显示文摘 | Soares R M D Lima A M F Oliveira R V B | 2005 | Polym Degrad Stab2005，4，7： | 1 |
| 14 | Adaptive Genetic Algo- rithms for Dynamic Channel Assignment in Mobile Cellular Communication Systerns显示文摘 | Lima M A C Araujo A F R Cesar A C | 2007 | IEEE Transactions on Vehicular Technolgoy2007，56，5： | 1 |
| 15 | O-GlcNAcylation, a novel pathway contributing to the effects of endothelin in the vasculature显示文摘 | Lima V V Giachini F R Hardy D M | 2011 | Am] Physiol Regul Integr Comp Physiol2011，300，2： | 1 |
| 16 | Brazilian medicinal plant acts on prostaglandin level and helicobacter pylori显示文摘 | Lima Z P Calvo T R Silva E F Pellizzon C H Vilegas W Brim A R Bauab T M Hiruma-Lima C A | 2008 | Journal of Medicinal Food2008，11，4： | 1 |
| 17 | Clinical prognostic factors in malignant parotid gland tumors显示文摘 | LIMA R A TAVARES M R DIAS F L | 2005 | Otolaryngol Head Neck Surg2005，133，5： | 1 |
| 18 | The infrared spectra of amine collectors used in the flotation of iron ores显示文摘 | LIMA R M F BRANDAO P R G PERES A E C | 2005 | Minerals Engineering2005，18，2： | 1 |
| 19 | An Integrated Framework for Cost Allocation in a Muhi-owned Transmission Systems显示文摘 | J W MARANGON LIMA M V F PEREIRA J L R PEREIRA | 1995 | IEEE Transactions on Power Systems1995，10，2： | 1 |
| 20 | Toxicity of a soybean oil emulsion on human lymphocytes and neutrophils显示文摘 | Cury-Boaventura M F Gorjao R de Lima T M | 2006 | JPEN2006，30，： | 1 |
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