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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Chinese Implicit Leadership Theory显示文摘 | Ling W Q Chia R C Fang L L | 2000 | The Journal of Social Psychology2000，140，6： | 1 |
| 4 | Pricing mortgage -backed securities: Integrating optimal call and empirical models of prepayment 显示文摘 | Archer W R Ling D C | 1993 | AREUEA1993，21，2： | 1 |
| 5 | Cooked rice aroma and 2-acetyl-l-pyrroline显示文摘 | Buttery R G Ling L C Juliano B O | 1983 | Agric Food Chem1983，31，82： | 1 |
| 6 | Scattering Center Param- eterization of wide-angle backscattered data using adaptive Gaussian representation 显示文摘 | Trintinalia L C Bhalla R Ling H | 1997 | IEEE Transactions on Antennas and Propagation1997，45，11： | 1 |
| 7 | Alloys of magnesium显示文摘 | Huddle R A U Ling J Jessup A C Emley E F | | 0，，： | 1 |
| 8 | Studies on flaovr volatiles of some sweet corn products显示文摘 | Buttery R G Stern D J Ling L C | 1982 | Journal of Agricultural and Food Chemistry1982，30，： | 1 |
| 9 | Molecular diagnosis of clear cell sarcoma: Detection of EWS-ATF1 and MITF transcripts and histopathological and ultrastruetural analysis of 12 ea- ses 显示文摘 | LING C R TSCHEMYAVSKY S J WOODRUFF J M | 2002 | J MolDiagn2002，4，1： | 1 |
| 10 | Optimizing the Aqueous Phase Synthesis of CdTe Quantum Dots Using Mixed-Ligands System and their Applications for Imaging of Live Cancer Cells and Tumors in Vivo 显示文摘 | Wang Y C Hu R LinG M | 2013 | RSC Advances2013，3，23： | 1 |
| 11 | Cron leaf volatiles:indentification using tenax trapping for possible insect attractants显示文摘 | Buttery R G Ling L C | | 0，，： | 1 |
| 12 | Additional volatile components of cabbage,broccoli, and cauliflower 显示文摘 | Buttery R G Guadagni D G Ling L C | 1976 | Journal of Agricultural and Food Chemistry1976，24，4： | 1 |
| 13 | Performance of photocatalytic reactors using immobilized TiO2 film for the degradation of phenol and methylene blue dye present in water stream 显示文摘 | Ling C M Mohamed A R Bhatia S | 2004 | Chemosphere2004，57，7： | 1 |
| 14 | Perfomanee of photocatalytic reactors using immobilized TiO2 film for the degradation of phenol and methylene blue dye present in water stream 显示文摘 | Ling C M Mohamed A R Bhatia S | 2004 | Chemosphere2004，57，7： | 1 |
| 15 | Differential protection against papaya ringspot virus isolates in coat protein gene transgenic papaya and classically cross-protected papaya显示文摘 | Gonsalves C Ling K-S Fitch M Manshardt R Siightom JL Gonsalves D | 1994 | Phytopa thology1994，64，： | 1 |
| 16 | Multi-Level Exposures and 3-D X-Ray Patterning for High-Aspect Ratio Microstructures 显示文摘 | Khan-Malek C Wood R Ling Z | 1998 | Microelectronic Engineering1998，4142，： | 1 |
| 17 | Shooting and bouncing rays: Calculating the RCS of an arbitrarily shaped cavity 显示文摘 | LING H CHOU R C LEE S W | 1989 | IEEE Trans on Antennas Propogation1989，，2： | 1 |
| 18 | Association of feather color with constitutively ac-tive Melanocortin I receptors in chicken 显示文摘 | LING M K LAGERSTROM M C FREDRIKSSON R | 2003 | Eur J Bioehem2003，270，： | 1 |
| 19 | Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion显示文摘 | Ling C Del Guerra S Lupi R | 2008 | Diabetologia2008，51，4： | 1 |
| 20 | Quantitative andsensory studies on tomato paste volatiles显示文摘 | BUTTERY R G TERANISHI R LING L C | 1990 | J Agric Food Chem1990，38，1： | 1 |
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