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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Down-regulation of intrinsic P-glycoprotein expression in Down-regula- tion of intrinsic P-glycoprotein expression in multicellular prostate tumor spheroids by reactive oxygen species显示文摘 | Ling F C Schallenberg M | 2001 | J Biol Chem2001，276，17： | 1 |
| 3 | X-ray Crystal Structure of Rocaglamide, a Novel Antileukemic ^1H-Cyclopenta benzofuran from Aglaia Elliptifolia显示文摘 | KING M L CHIANG C C LING H C | 1982 | J Chem Soc Chem Commun1982，，： | 1 |
| 4 | Effects of various metals and their loading methods on the mesopore formation in pitch-based spherical activated carbon显示文摘 | Liu Z C Ling L C Qiao W M | 1999 | Carbon1999，37，8： | 1 |
| 5 | Degradation of cardiac troponin 1 in serum complicates of cardiac troponin 1 assays显示文摘 | Shi Q W Ling M F Zhang X C | 1999 | Clin Chem1999，45，7： | 1 |
| 6 | Recognition of Grenvillian volcanic suite in the Shennongjia region and its tectonic significance for the South China Craton 显示文摘 | Qiu X F Ling W L Liu X M Kusky T Berkana W ZhangY H Gao Y J Lu S S Kuang H Liu C X | 2011 | Precambrian Research2011，191，： | 1 |
| 7 | Single-ion gibbs energies, enthalpies and entropies of transfer from water to aqueous methanol bases on the (Ph4P, Ph4As ) = Ph4B- assumption显示文摘 | ABRAHAM M H HILL T LING H C | 1984 | Journal of the Chemi- cal Society-Faraday Transactions I1984，80，2： | 1 |
| 8 | Tumor-induced angiogenesis studied confrontation cultures multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells显示文摘 | Wartenberg M Donmez F Ling F C | 2001 | FASEB J2001，15，6： | 1 |
| 9 | Preparation of a pitchbased activated carbon with a high specific surface area 显示文摘 | Qiao w M Ling L C Zha Q F | 1997 | J Mater Sci1997，32，： | 1 |
| 10 | Initiation of immune responses in brain is promoted by local dendritic cells显示文摘 | Karman J Ling C Sandor M | 2004 | J Immunol2004，173，4： | 1 |
| 11 | Green leaf volatiles enhance sex attractant p-heromone of the tobacco budworm,Heliothis virescens显示文摘 | Dickens J C Smith J N Ling D M | 1993 | Chemoecology1993，4，： | 1 |
| 12 | Analysis and detection of the chemical constituents of Radix Polygalae and their metabolites in rats after oral administration by ultra high- performance liquid chromatography coupled with electrospray ionization quadr-upole time-of-flight tandem mass spectrometry显示文摘 | Ling Y Li Z X Chen M C | 2013 | J Pharm Biomed Anal2013，85，： | 1 |
| 13 | Identification of Source Locations in Two-Dimensional Heat Equations显示文摘 | LING L YAMAMOTO M HON Y C | 2006 | Inverse Problems2006，22，： | 1 |
| 14 | Purification of two de-pressant insect neurotoxins and their gene cloning from the scorpion Buthusmartensii Karsch显示文摘 | Wang C G Ling M H Chi C W | 2003 | Journal of Peptide Re search2003，61，1： | 1 |
| 15 | Molecular diagnosis of clear cell sarcoma: Detection of EWS-ATF1 and MITF transcripts and histopathological and ultrastruetural analysis of 12 ea- ses 显示文摘 | LING C R TSCHEMYAVSKY S J WOODRUFF J M | 2002 | J MolDiagn2002，4，1： | 1 |
| 16 | Optimizing the Aqueous Phase Synthesis of CdTe Quantum Dots Using Mixed-Ligands System and their Applications for Imaging of Live Cancer Cells and Tumors in Vivo 显示文摘 | Wang Y C Hu R LinG M | 2013 | RSC Advances2013，3，23： | 1 |
| 17 | Nature of the Acceptor Responsible for p-Type Conduction in Liquid Encapsulated Czochralski-Grown Undoped Gallium Antimonide显示文摘 | Ling C C Lui M K Ma S K | 2004 | Appl Phys Lett2004，85，： | 1 |
| 18 | Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages显示文摘 | Ling Y M Shaw M H Ayala C | 2006 | The Journal of experimental medicine2006，203，9： | 1 |
| 19 | Identification of pulmonary Oct-4+stem/progenitor cells and demonstration of their susceptibility to SARS coronavims (SARS-CoV) infection in Vitro显示文摘 | KUO M D LI C L | 2006 | Proc Natl Acad Sci U S A2006，103，25： | 1 |
| 20 | Expression of purinergic receptors in non melanoma skin cancers and their functional roles in A431 cells显示文摘 | Greig A V Linge C Healy V Lim P Clayton E Rustin M H | 2003 | J Invest Dermatol2003，121，： | 1 |
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