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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet2001，，9286： | 4 |
| 3 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | The Lancet . 2001 (9286)2001，，9286： | 4 |
| 4 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial显示文摘 | Michael P Manns John G McHutchison Stuart C Gordon Vinod K Rustgi Mitchell Shiffman Robert Reindollar Zachary D Goodman Kenneth Koury Mei-Hsiu Ling Janice K Albrecht | 2001 | 2001 (9286)2001，，9286： | 4 |
| 5 | 云南省农村地区男男性接触者与HIV相关的风险行为显示文摘目的探讨中国农村地区男男性接触者(MSM)与艾滋病病毒(HIV)相关的风险行为的具体特点和问题。方法采用半结构化深度访谈的方式进行定性研究。通过一个当地的MSM联系网络,以滚雪球和相互转告的方式招集了24名访谈对象。主要测量指标是与HIV有关的风险行为的上升情况。结果在中国农村地区,风险行为、社会歧视、独生子女政策以及传统中医的观念,在HIV的传播中都起着重要的作用。在中国,许多MSM过着双重生活;调查显示,安全套的使用情况也是因人而异,使风险行为'合理化'的意图是决定是否使用安全套的主要因素;就泌尿生殖系统的问题主动寻求医疗帮助的现象很不普遍,而现有卫生系统以及医务人员对此问题表现出来的不敏感,也进一步加剧了这种现象。结论在资源匮乏的农村地区,MSM人群存在着HIV流行的趋势,并有向普通人群传播的危险。 | 张建波 黄志威 T S K Kong D C Y Ling | 2007 | 中国艾滋病性病2007，13，5： | 3 |
| 6 | Preparation of mesocarbon microbeads from coal tar 显示文摘 | LU Y G LING L C WU D | 1999 | Journal of Material Science1999，34，16： | 1 |
| 7 | Investigation of the noise reduction provided by tree behs显示文摘 | Fang C F Ling D L | 2003 | Landscape Urban Plan2003，3，： | 1 |
| 8 | Pricing mortgage -backed securities: Integrating optimal call and empirical models of prepayment 显示文摘 | Archer W R Ling D C | 1993 | AREUEA1993，21，2： | 1 |
| 9 | Effect of tidal forcing on a subterranean estuary 显示文摘 | Robinson C Li Ling Barry D A | 2007 | Advances in Water Resources2007，30，4： | 1 |
| 10 | New index of combined systolic and diastolic myocardial performance:a simple and reproducible measure of cardiac function a study in normals and dilated cardiomyopathy 显示文摘 | TEl C LING L H HODGE D O | 1995 | J Cardiol1995，26，6： | 1 |
| 11 | The effect of setup uncertainties on the radiobiological advantage of fractionation in stereotaxic radiotherapy显示文摘 | Lo Y C Ling C C Larson D A | 1996 | In J Radiat Oncol Biol Plays1996，34，5： | 1 |
| 12 | The Neural Mechanism Underlying the Female Advantage in Identifyin Negative Emotions: An Event-related Potential Study 显示文摘 | YUAN J J LING C D | 2008 | Neuroimage2008，，40： | 1 |
| 13 | Lipopolysaccharide (LPS)-induced dopamine cell loss in culture: roles of tumor necrosis factor-alpha, interleukin-1 beta, and nitric oxide显示文摘 | GAYLE D A LING Z TONG C | 2002 | Brain Res Dev Brain Res2002，133，1： | 1 |
| 14 | Green leaf volatiles enhance sex attractant p-heromone of the tobacco budworm,Heliothis virescens显示文摘 | Dickens J C Smith J N Ling D M | 1993 | Chemoecology1993，4，： | 1 |
| 15 | Studies on flaovr volatiles of some sweet corn products显示文摘 | Buttery R G Stern D J Ling L C | 1982 | Journal of Agricultural and Food Chemistry1982，30，： | 1 |
| 16 | Defect Study of Zn-Doped p-Type Gallium Antimonide using Positron Lifetime Spectroscopy显示文摘 | Ling C C Fung S Beling C D at al | 2001 | Phys Rev B2001，64，07： | 1 |
| 17 | Randomised trial of safety and efficacy of immediate postoperative enteral feeding in patients undergoing gastrointestinal resection显示文摘 | Carr C S Ling K D Boulos P | 1996 | BMJ1996，312，7035： | 1 |
| 18 | New index of combined svstolic and diastolic myocardial performance:a simple and reproducible measure of cardiac function-a study in normals and dilated cardiomyopathy显示文摘 | Tei C Ling L H Hodge D O | 1995 | J Cardiol1995，26，6： | 1 |
| 19 | Connectedness of cone super efficient point sets in locally convex topological spaces显示文摘 | Hu Y D Ling C | 2000 | J Optim Theory Appl2000，107，2： | 1 |
| 20 | Identification of pulmonary Oct-4+stem/progenitor cells and demonstration of their susceptibility to SARS coronavims (SARS-CoV) infection in Vitro显示文摘 | KUO M D LI C L | 2006 | Proc Natl Acad Sci U S A2006，103，25： | 1 |
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