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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Acousto-Optic Tunable Flters: Fundamentals and Applications as Applied to Chemical Analysis Techniques显示文摘 | Ling B Glenn I D Heather M M | 2004 | Progress in Quantum Electronics2004，，28： | 1 |
| 3 | , Relation of Cd4+ CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease 显示文摘 | Ling E M Smith T Nguyen X D | 2004 | Lancet2004，363，9409： | 1 |
| 4 | Mitotic arrest deficient 2 expression induces chemosensitization to a DNA damaging agent, cisplatin, in nasopharyngeal carcinoma cells显示文摘 | Cheung H W Jin D Y Ling M T | 2005 | Cancer Res2005，65，8： | 1 |
| 5 | Green leaf volatiles enhance sex attractant p-heromone of the tobacco budworm,Heliothis virescens显示文摘 | Dickens J C Smith J N Ling D M | 1993 | Chemoecology1993，4，： | 1 |
| 6 | Anisotropic Elastoplastic Bounding Surface Model for Cohesive Soils 显示文摘 | Ling H I Asce A M Yue D Y | 2002 | Journal of Engineering Mechanics2002，，6： | 1 |
| 7 | Identification of pulmonary Oct-4+stem/progenitor cells and demonstration of their susceptibility to SARS coronavims (SARS-CoV) infection in Vitro显示文摘 | KUO M D LI C L | 2006 | Proc Natl Acad Sci U S A2006，103，25： | 1 |
| 8 | RFLP analysis of SLA haplotypes in Swiss Large White and American Hampshire pigs using SLA class Ⅰand class Ⅱ probes显示文摘 | Gautischi C Ling M S Beever J E Mclaren D G Lewin H A Schook L B | 1991 | Animal Biotechnology1991，2，： | 1 |
| 9 | Draft genome of the wheata-genome progenitor Triticum urartu显示文摘 | Ling HQ Zhao S Liu D Wang J Sun H Zhang C Fan H Li D Dong L Tao Y Gao C Wu H Li Y Cui Y Guo X Zheng S Wang B Yu K Liang Q Yang W Lou X Chen J Feng M Jian J Zhang X Luo G Jiang Y Liu J Wang Z Sha Y Zhang B WuH Tang D Shen Q Xue P Zou S Wang X Liu X Wang F Yang Y An X Dong Z Zhang K Zhang X Luo MC Dvorak J Tong Y Wang J Yang H Li Z Wang D Zhang A Wang J | 2013 | Nature2013，469，7443： | 1 |
| 10 | Differential protection against papaya ringspot virus isolates in coat protein gene transgenic papaya and classically cross-protected papaya显示文摘 | Gonsalves C Ling K-S Fitch M Manshardt R Siightom JL Gonsalves D | 1994 | Phytopa thology1994，64，： | 1 |
| 11 | Different origins of adakites from the Dabie mountains and the Lower Yangtze River Belt, Eastern China: Geochemical constraints显示文摘 | LING M X WANG F Y DING X ZHOU J B SUN W D | 2011 | International Geology Review2011，53，： | 1 |
| 12 | Macro-particle reduction mechanism in biased arc ion plating of TiN显示文摘 | HUANG M D LING Q ZHAO Y H | | 0，，： | 1 |
| 13 | Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine 显示文摘 | Ling R Mutimer D Ahmed M | 1996 | Hepatology1996，24，： | 1 |
| 14 | Soil slopes under combined horizontal and vertical seismic accelerations显示文摘 | Ling H I Leshchinsky D Yoshiyuki M | 1997 | Earthquake Engineering and Structural Dynamics1997，26，12： | 1 |
| 15 | Dosimetric verification of dynamic intensity-modulated radiation therapy of 92 patients 显示文摘 | TSAI J S WAZER D E LING M N | 1998 | Int J Radiat Oncol Biol Phys1998，40，5： | 1 |
| 16 | An approximate analysis of the three-dimensional effects of diaphragm wall installation 显示文摘 | Ng C W W Lings M L Simpson B & Nash D F T | | Geotechnique0，45，3： | 1 |
| 17 | Stability of quantized control systems under dynamic bit assignment显示文摘 | Ling Q Lemmon M D | | 0，，05： | 1 |
| 18 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 19 | Anisotropic stiffness parameters and their measurement in a stiff natural clay显示文摘 | Lings M L Pennington D S Nash | 2001 | Geotechnique2001，50，2： | 1 |
| 20 | Synchrotron FTIR microspec- troscopy of single natural silk fibers 显示文摘 | Ling S J Qi Z M Knight D P | | Biomacromolecules0，12，9： | 1 |
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