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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | 云南省农村地区男男性接触者与HIV相关的风险行为显示文摘目的探讨中国农村地区男男性接触者(MSM)与艾滋病病毒(HIV)相关的风险行为的具体特点和问题。方法采用半结构化深度访谈的方式进行定性研究。通过一个当地的MSM联系网络,以滚雪球和相互转告的方式招集了24名访谈对象。主要测量指标是与HIV有关的风险行为的上升情况。结果在中国农村地区,风险行为、社会歧视、独生子女政策以及传统中医的观念,在HIV的传播中都起着重要的作用。在中国,许多MSM过着双重生活;调查显示,安全套的使用情况也是因人而异,使风险行为'合理化'的意图是决定是否使用安全套的主要因素;就泌尿生殖系统的问题主动寻求医疗帮助的现象很不普遍,而现有卫生系统以及医务人员对此问题表现出来的不敏感,也进一步加剧了这种现象。结论在资源匮乏的农村地区,MSM人群存在着HIV流行的趋势,并有向普通人群传播的危险。 | 张建波 黄志威 T S K Kong D C Y Ling | 2007 | 中国艾滋病性病2007，13，5： | 3 |
| 3 | Changes in micro-RNA profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes显示文摘 | Ling H Y Ou H S Feng S D | | 0，，09： | 1 |
| 4 | Bio-organic fertilizer application significantly reduces the Fusarium oxysporum population and alters the composition of fungi communities of watermelon Fusarium wilt rhizosphere soil显示文摘 | Zhao S Liu D Y Ling N | 2014 | Biol Fertil Soils2014，50，： | 1 |
| 5 | Production, purification and characterization of anintracellar aflatoxin - detoxifizyme from Armillariella tabescens (E- 20) 显示文摘 | Liu D L Yao D S Ling R | 2001 | Food and Chemical Toxicology2001，39，： | 1 |
| 6 | On the least squares estimation of multiple-regime TAR models显示文摘 | Li D Ling S | 2012 | Journal of Econometrics2012，167，1： | 1 |
| 7 | Dense phase conveying of fine coal at high total pressure显示文摘 | Oeldart D Ling S J | 1990 | Powder Technology1990，62，3： | 1 |
| 8 | Defect Study of Zn-Doped p-Type Gallium Antimonide using Positron Lifetime Spectroscopy显示文摘 | Ling C C Fung S Beling C D at al | 2001 | Phys Rev B2001，64，07： | 1 |
| 9 | Randomised trial of safety and efficacy of immediate postoperative enteral feeding in patients undergoing gastrointestinal resection显示文摘 | Carr C S Ling K D Boulos P | 1996 | BMJ1996，312，7035： | 1 |
| 10 | Clinical and experimental research of corneal lymphangiogenesis after keratoplasty显示文摘 | Ling S Lin H Xiang D | 2008 | Ophthalmologica2008，222，5： | 1 |
| 11 | Complete nucleotide sequence and genome organization of Grapevine leafroll-associated virus 3, type member of the genus Ampelovirus显示文摘 | Ling K S Zhu H Y Gonsalves D | 2004 | Journal of General Virology2004，85，： | 1 |
| 12 | Face stability analysis of shallow shield tunnels in dry sandy ground using the discrete element method显示文摘 | CHEN R P TANG L J LING D S | 2011 | Computers and Geotechnics2011，38，： | 1 |
| 13 | RFLP analysis of SLA haplotypes in Swiss Large White and American Hampshire pigs using SLA class Ⅰand class Ⅱ probes显示文摘 | Gautischi C Ling M S Beever J E Mclaren D G Lewin H A Schook L B | 1991 | Animal Biotechnology1991，2，： | 1 |
| 14 | Draft genome of the wheata-genome progenitor Triticum urartu显示文摘 | Ling HQ Zhao S Liu D Wang J Sun H Zhang C Fan H Li D Dong L Tao Y Gao C Wu H Li Y Cui Y Guo X Zheng S Wang B Yu K Liang Q Yang W Lou X Chen J Feng M Jian J Zhang X Luo G Jiang Y Liu J Wang Z Sha Y Zhang B WuH Tang D Shen Q Xue P Zou S Wang X Liu X Wang F Yang Y An X Dong Z Zhang K Zhang X Luo MC Dvorak J Tong Y Wang J Yang H Li Z Wang D Zhang A Wang J | 2013 | Nature2013，469，7443： | 1 |
| 15 | Dense phase conveying of fine coal at high total pressure显示文摘 | Geldart D Ling S J | 1990 | Powder Technology1990，62，： | 1 |
| 16 | Diversity of vegeta- tive compatibility types and mating types of Cryphonectria parasitica in Slovenia and occurrence of associated Cryphonectria hypovirus 1显示文摘 | Krstin L Novak-Agbaba S Rig ling D | 2011 | Plant Pathology2011，60，4： | 1 |
| 17 | Computational experiments reveal the efficacy of targeting CDK2 and CKIs for significantly lowering cellular senescence bar for potential cancer treatment 显示文摘 | Ling H Samarasinghe S Kulasiri D | 2013 | Biosystems2013，111，2： | 1 |
| 18 | Interface Formation between the Al Electrode and Poly (PFT) Investigated in Situ by XPS显示文摘 | Ling Q D Li S Kang E T | 2002 | Applied Surface Science2002，199，： | 1 |
| 19 | Chemical States and Electronic Properties of the Interface between Aluminium and a Photoluminescent Conjugated Copolymer Containing Europium Complex显示文摘 | Cai Q J Ling Q D Li S | 2004 | Applied Surface Science2004，222，： | 1 |
| 20 | Clinical and experimental research of corneal lymphangiogenesis after kemtoplasty显示文摘 | Ling S Lin H Xiang D | 2008 | Ophthalmologica2008，222，5： | 1 |
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