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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Pricing mortgage -backed securities: Integrating optimal call and empirical models of prepayment 显示文摘 | Archer W R Ling D C | 1993 | AREUEA1993，21，2： | 1 |
| 3 | Shape classification using the inner-distance显示文摘 | Ling H B Jacobs D W | | 0，，02： | 1 |
| 4 | Mitotic arrest deficient 2 expression induces chemosensitization to a DNA damaging agent, cisplatin, in nasopharyngeal carcinoma cells显示文摘 | Cheung H W Jin D Y Ling M T | 2005 | Cancer Res2005，65，8： | 1 |
| 5 | Study on biogas production by mesophilic fermentation with conyza canadensis显示文摘 | ZHANG L J LING W D ZHANG W D | 2013 | Advanced Materials Research2013，788，： | 1 |
| 6 | Multiple input multiple output measurements and modeling in Manhattan 显示文摘 | Chizhik D Ling J Wolniansky P W | 2003 | Selected Areas in Communications2003，21，3： | 1 |
| 7 | ' Holistic boolean-twig pattern matching for effi- cient XML query processin 显示文摘 | Che D Ling T Hou W | 2012 | IEEE Trans on Knowledge and Data Engineering2012，24，11： | 1 |
| 8 | A 42-V electrical and hybrid driving system based on a vehicular waste- heat thermoelectric generator显示文摘 | Deng Y D Fan W Ling K | 2012 | Journal of Electronic Materials2012，41，16： | 1 |
| 9 | Preparation of nitro- gen-doped graphene sheets by a combined chemical and hydrothermal reduction of graphene oxide 显示文摘 | Long D H Li W Ling L C | 2010 | Langmuir2010，26，16： | 1 |
| 10 | Draft genome of the wheata-genome progenitor Triticum urartu显示文摘 | Ling HQ Zhao S Liu D Wang J Sun H Zhang C Fan H Li D Dong L Tao Y Gao C Wu H Li Y Cui Y Guo X Zheng S Wang B Yu K Liang Q Yang W Lou X Chen J Feng M Jian J Zhang X Luo G Jiang Y Liu J Wang Z Sha Y Zhang B WuH Tang D Shen Q Xue P Zou S Wang X Liu X Wang F Yang Y An X Dong Z Zhang K Zhang X Luo MC Dvorak J Tong Y Wang J Yang H Li Z Wang D Zhang A Wang J | 2013 | Nature2013，469，7443： | 1 |
| 11 | Different origins of adakites from the Dabie mountains and the Lower Yangtze River Belt, Eastern China: Geochemical constraints显示文摘 | LING M X WANG F Y DING X ZHOU J B SUN W D | 2011 | International Geology Review2011，53，： | 1 |
| 12 | Expression of urokinase plasminogen activator and plasminogen activator inhibitor type-1 in ovarian cancer and its clinical significance显示文摘 | Zhang W Ling D Tan J | 2013 | Oncol Rep2013，29，2： | 1 |
| 13 | Preparation of nitrogen-doped graphene sheets by a combined chemical and hydrothermal reduction of graphene oxide显示文摘 | LONG D H LI W LING L C | 2010 | Langrnuir2010，26，16： | 1 |
| 14 | Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines显示文摘 | Ling Z D Potter E D Lipton J W | 1998 | Exp Neurol1998，149，2： | 1 |
| 15 | An approximate analysis of the three-dimensional effects of diaphragm wall installation 显示文摘 | Ng C W W Lings M L Simpson B & Nash D F T | | Geotechnique0，45，3： | 1 |
| 16 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 17 | Evidence on the Impact of Internal Control and Corporate Govemanceon Audit Fees 显示文摘 | Hay D Knechel W R Ling H | 2008 | International Journal of Auditing2008，，12： | 1 |
| 18 | Superheating and supercooling of vortex matter in a Nb single crystal: Direct evidence for a phase transition at the peak effect from neutron diffraction显示文摘 | Ling X S Park S R McClain B A Choi S M Dender D C Lynn J W | | 0，，： | 1 |
| 19 | Effective PEGylation of iron oxide nanoparticles for high performance in vivo cancer imaging显示文摘 | Liu D F Wu W Ling J J | 2011 | Advanced Functional Materials2011，21，8： | 1 |
| 20 | Effect of ticarillin potassium clavulante on callus growth and shoot regeneration in Agrobacterium tumefaciens -mediated transformation of tomato (Lycopersicon esculentum) 显示文摘 | Ling H Q Kriseleit D Canal M W | 1998 | Plant Cell Report1998，17，： | 1 |
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