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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Direct numerical simulation of a three-dimensional temporal mixing layer with particle dispersion显示文摘 | Ling W Chung J N Troutt T R | 1998 | J Fluid Mech1998，358，： | 1 |
| 3 | Direct numerical simulation of a three-dimensional temporal mixing layer with particle dispersion 显示文摘 | Ling W Chung J N Troutt T R | 1998 | Journal of Fluid Mechanics1998，358，： | 1 |
| 4 | Sorption of phenanthrene by soils contaminated with heavy metals 显示文摘 | Gao Y Z Xiong W Ling W T | 2006 | Chemosphere2006，65，： | 1 |
| 5 | A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China显示文摘 | You-lin Qiao John W Sellors Paul S Eder Yan-ping Bao Jeanette M Lim Fang-hui Zhao Bernhard Weigl Wen-hua Zhang Roger B Peck Ling Li Feng Chen Qing-jing Pan Attila T Lorincz | 2008 | Lancet Oncology2008，，10： | 1 |
| 6 | Mitotic arrest deficient 2 expression induces chemosensitization to a DNA damaging agent, cisplatin, in nasopharyngeal carcinoma cells显示文摘 | Cheung H W Jin D Y Ling M T | 2005 | Cancer Res2005，65，8： | 1 |
| 7 | Shear strengthcharacterization of municipal solid waste at the Suzhou landfill,China显示文摘 | Zhan T L T Chen Y M Ling W A | 2008 | Engineering Geology2008，97，34： | 1 |
| 8 | Recognition of Grenvillian volcanic suite in the Shennongjia region and its tectonic significance for the South China Craton 显示文摘 | Qiu X F Ling W L Liu X M Kusky T Berkana W ZhangY H Gao Y J Lu S S Kuang H Liu C X | 2011 | Precambrian Research2011，191，： | 1 |
| 9 | Holistic boolean-twig pat- tern matching for efficient XML query processing 显示文摘 | CHE Dun-ren LING T W HOU Wen-chi | 2012 | I EEE Trans on Knowledge and Data Engineering2012，24，11： | 1 |
| 10 | Adsorption of polyethyleneglycol (PEG) from aqueous solution onto hydrophobic zeolite 显示文摘 | Chang C Y Tsai W T Ling C H | 2003 | Journal of Colloid and Interface Science2003，260，2： | 1 |
| 11 | Extended XML tree pat- tern matching: theories and algorithms 显示文摘 | LU Jia-heng LING T W BAO Zhi-feng | 2011 | IEEE Yrans on Know- ledge and Data Engineering2011，23，3： | 1 |
| 12 | Estimates of bottom rough- ness length and bottom shear stress in South San Francisco Bay Cali- fornia显示文摘 | Ralph T C Ling C H Gartner J W | 1999 | Journal of Geophysical Research1999，104，7： | 1 |
| 13 | ' Holistic boolean-twig pattern matching for effi- cient XML query processin 显示文摘 | Che D Ling T Hou W | 2012 | IEEE Trans on Knowledge and Data Engineering2012，24，11： | 1 |
| 14 | Shear strengthcharacterization of municipal solid waste at the Suzhou land-fill,China显示文摘 | Zhan Tony L T Chen Y M Ling W A | 2008 | Engineering Geology2008，97，34： | 1 |
| 15 | Interleukin-1 mediates Alzheiner and Lewy body pathologies显示文摘 | Sue W Griffin T Ling Liu | | 0，，03： | 1 |
| 16 | Effect of organic acids of copper and cadmium desorption from contaminated soils显示文摘 | GAO Y Z HE J Z LING W T | 2003 | Environment International2003，29，： | 1 |
| 17 | Interleukin-1 mediates Alzheimer and Lewy body pathologies 显示文摘 | Sue W Griffin T Liu Ling | 2006 | J Neuroinflammation2006，3，： | 1 |
| 18 | Sorption of phenanthrene by soils contaminated with heavy metals 显示文摘 | Gao Y Z Xiong W Ling W T | 2006 | Chemosphere2006，65，： | 1 |
| 19 | Image Retrieval Based on Object's Orientation Spatial Relationalship显示文摘 | Zhou X M Ang C H Ling T W | 2001 | PRL2001，22，5： | 1 |
| 20 | Room occupancies:Cruise lines out-do the hotels显示文摘 | Toh R S Rivers M J Ling T W | | 0，，01： | 1 |
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