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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 3 | Using computational auditory models to predict simultaneous masking data: model comparison显示文摘 | LISA G H LESLIE M C | 1999 | IEEETransactions on Biomedical Engineering1999，46，12： | 1 |
| 4 | Leptin is a four - helix bundle:secondary structure by NMR显示文摘 | Allen D K Gerald W B Lisa M C | 1997 | FEBS Letters1997，407，2： | 1 |
| 5 | Quantification of deoxynivalenol in wheat using an immunoaffinity column and liquid chromatography显示文摘 | Scott C Kruger Brian T McAlice | 1999 | Journal of Chromatography A1999，859，： | 1 |
| 6 | The effect of apre-load meal containing resistant starch on spontaneous food intake and glucose and insulin responses 显示文摘 | Cyril W C Kendall Amin Esfahani Lisa M Sanders | 2010 | Journal of Food Technology2010，8，2： | 1 |
| 7 | Copper toxicity, oxidative stress andantioxidantnutrients 显示文摘 | Lisa M Ching K C | 2003 | Toxicology2003，189，14： | 1 |
| 8 | The effect of a pre load meal containing resistant starch on spontane- ous food intake and glucose and insulin responses显示文摘 | Cyril W C Kendall Amin Esfahani Lisa M Sanders | 2010 | Journal of Food Technology2010，8，2： | 1 |
| 9 | Quantification of deoxynivalenol in wheat using an immunoaffinity column and liquid chromatography显示文摘 | Scott C Kruger Brian T McAlice | 1999 | Journal of Chromatography A1999，859，： | 1 |
| 10 | Lack of energy compensation over 4 days when white button mushrooms are substi- tuted for beef显示文摘 | LAWRENCE J C LISA M D LEAH M L | 2008 | Appetite2008，51，1： | 1 |
| 11 | The avian coronavirus Infectious bronchitis virus undergoes direct low-pH-dependent fusion activation during entry into host cells显示文摘 | Victor C Lisa J Chu M V | 2006 | Journal of Virology2006，80，： | 1 |
| 12 | Colonization, succession, and nutrition of macrobenthic assemblages in a restored wetland at Tijuana Estuary, California显示文摘 | Serena M M Lisa A L Carolyn C | 2004 | Estuary Coast & Shelf Science2004，60，： | 1 |
| 13 | Syntheses of 4'epi-antino-4'-deoxyavermectins B1显示文摘 | Raymond J C Dennis H K Lisa M D | 1994 | J Org Chem1994，59，： | 1 |
| 14 | The adjuvant effects of Mycobacterium tuberculosis heat shock protein 70 result form the rapid and prolonged activation of antigen-specific CD8+T cells in vivo显示文摘 | Elizabeth G I Julie M C | 2002 | J Immunol2002，169，： | 1 |
| 15 | HSLA-100 steels: Influence of aging heat treatment on microstrueture and properties 显示文摘 | MUJAHID M LISA K GARCIA C I | 1998 | Journal of matezials engineering and performance1998，7，2： | 1 |
| 16 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 1 |
| 17 | Qua-ntification of deoxynivalenol in wheat using an immimoaff-inity eolumn and liquid chromatography显示文摘 | Lisa M Cahill Scott C Kruger Brian T McAlice | 1999 | Journal of chr-omatography A1999，859，： | 1 |
| 18 | Supply Chain Management,Parther Ships,and the Shipper -third -party rela2tionship 显示文摘 | ELLRAM LISA M MARTHA C Copper | 1990 | The International Journal of Logistics Management1990，，2： | 1 |
| 19 | Prostate cancer in African American: Relationship of patient and partner self - efficacy to quality of Iife显示文摘 | Lisa C C Francis J K Daphne C M | 2004 | Journal of Pain and Symptom Management2004，28，5： | 1 |
| 20 | Irrigation cooling effect: Regional climate forcing by land-use change 显示文摘 | Lara M Kueppers Mark A Snyder Lisa C Sloan | 2007 | Geophysical Research Letters2007，34，： | 1 |
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