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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | Laparoscopic liver resection:Experience based guidelines显示文摘Laparoscopic liver resection(LLR) has been progressively developed along the past two decades. Despite initial skepticism, improved operative results made laparoscopic approach incorporated to surgical practice and operations increased in frequency and complexity. Evidence supporting LLR comes from case-series, comparative studies and meta-analysis. Despite lack of level 1 evidence, the body of literature is stronger and existing data confirms the safety, feasibility and benefits of laparoscopic approach when compared to open resection. Indications for LLR do not differ from those for open surgery. They include benign and malignant(both primary and metastatic) tumors and living donor liver harvesting. Currently, resection of lesions located on anterolateral segments and left lateral sectionectomy are performed systematically by laparoscopy in hepatobiliary specialized centers. Resection of lesions located on posterosuperior segments(1, 4a, 7, 8) and major liver resections were shown to be feasible but remain technically demanding procedures, which should be reserved to experienced surgeons. Hand-assisted and laparoscopy-assisted procedures appeared to increase the indications of minimally invasive liver surgery and are useful strategies applied to difficult and major resections. LLR proved to be safe for malignant lesions and offers some short-term advantages over open resection. Oncological results including resection margin status and long-term survival were not inferior to open resection. At present, surgical community expects high quality studies to base the already perceived better outcomes achieved by laparoscopy in major centers' practice. Continuous surgical training, as well as new technologies should augment the application of lap-aroscopic liver surgery. Future applicability of new technologies such as robot assistance and image-guided surgery is still under investigation. | fabricio ferreira coelho jaime arthur pirola kruger gilton marques fonseca raphael leonardo cunha araújo vagner birk jeismann marcos vinícius perini renato micelli lupinacci ivan cecconello paulo herman | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 22 |
| 3 | 基于滑窗QR和快速PCA算法的自适应子空间辨识显示文摘基于滑窗QR分解不但能快速、准确地更新正交投影,同时还可提供其协方差的rank-k更新表达,提出了一个用于信号子空间更新的快速PCA算法.通过对进行主元分析(PCA)计算的非线性迭代部分最小二乘算法(Non-linear Iterative Partial Least Squares,NIPALS)计算过程的改进,将特征向量的更新转化为小维度辅助向量的更新,在满足特征值和特征向量更新精度的同时,有效地提高了计算速度.将滑窗QR和快速PCA算法用于子空间辨识算法的自适应更新,数值仿真验证了此自适应子空间辨识算法的有效性. | 李喆 谢磊 孙培 WANG Xun KRUGER Uwe | 2015 | 上海交通大学学报2015，49，11： | 5 |
| 4 | High mobility group protein-mediated transcription requires DNA damage marker γ-H2AX显示文摘 | Indrabahadur Singh Nihan Ozturk Julio Cordero Aditi Mehta Diya Hasan Claudia Cosentino Carlos Sebastian Marcus Kruger Mario Looso Gianni Carraro Saverio Bellusci Werner Seeger Thomas Braun Raul Mostoslavsky Guillermo Barreto | 2015 | Cell Research2015，25，7： | 5 |
| 5 | Critical appraisal of conventional semen analysis in the context of varicocele显示文摘精索静脉曲张在约 15% 人是在场的,并且,尽管它是男不孕的最通常诊断的原因,有精索静脉曲张的将近三分之二个人仍然保持肥沃。使用象盖住这个领域的可得到的文章一样从在 2004 和 2015 之间的以前的元分析获得的当前的证据被决定,在修理前后处理精液分析的话题的最好使随机化的控制文章。二重要元分析象在 varicocelectomy 前后处理精液分析的话题的另外的文章一样被讨论。证据建议所有精液参数在精索静脉曲张修理以后改善。基于可得到的证据,在与摸得出的精索静脉曲张对待人有一个好处,是清楚的。一个人能期望所有精液参数将在修理以后在 3 个月以内改善。 | Thinus Kruger | 2016 | Asian Journal of Andrology2016，18，2： | 3 |
| 6 | Exploring the contribution of the mitochondrial disulfide relay system to Parkinson’s disease:the PINK1/CHCHD4 interplay显示文摘Parkinson’s disease(PD)is a common movement disorder of the elderly caused by the degeneration of dopaminergic neurons in the substantia nigra pars compacta of the brain.Both environmental and genetic factors pointed out mitochondrial dysfunction as a major cause of neurodegeneration in PD.Pioneering studies using mitochondrial toxins revealed their ability to trigger dopaminergic cell death and irreversible parkinsonism in different animal models(Poewe et al.,2017).Typical features of mitochondrial dysfunction have been also observed in the human brain of idiopathic PD cases,showing alterations of respiratory chain complex I and IV activity,accumulation of mtDNA deletions and increased oxidative stress(Bender et al.,2006).Moreover,a number of genes found mutated in familial PD forms encode for proteins involved in the maintenance of mitochondrial homeostasis and quality control.Among these,the PINK1 gene encodes a mitochondrial serine/threonine kinase implicated in key neuroprotective functions,including mitophagy,regulation of mitochondrial transport,control of the mitochondria/endoplasmic reticulum crosstalk and calcium homeostasis(Brunelli et al.,2020). | Giuseppe Arena Nazanine Modjtahedi Rejko Kruger | 2021 | Neural Regeneration Research2021，16，11： | 3 |
| 7 | 含高钙和维生素D的强化奶能有效提高健康的绝经后的中国女性体内的维生素D水平并减少骨吸收显示文摘目的钙摄入水平低以及体内维生素D不足是导致亚洲女性罹患骨质疏松的危险因素。此项研究的目的是评估高钙维生素D强化牛奶(HCM)对健康的中国绝经后妇女的体内维生素D状态和骨吸收标志物进行干预的影响。方法本试验对象为55岁以上,绝经至少5年的女性。共有124名女性进行了总体健康状况和骨密度检查筛选。63名女性被随机分为对照组和试验组,试验组在12w内每日饮用两次高钙/维生素D强化奶(含900 mg钙、96 mg镁、2.4 mg锌和6.4μg维生素D)。2组分别在试验开始、试验2 w、8 w和12 w时测量血矿物质、25(OH)维生素D3和Ⅰ型胶原C端肽(CTX)水平。结果对照组女性平均年龄为63±4.6岁,高钙强化奶(HCM)组女性平均年龄为62±3.8岁。所测得的每日钙摄入量的基线值为HCM组260~482 mg,对照组为252~692 mg。12 w后HCM组的平均身体质量指数(BMI)显著降低(P<0.05)。HCM组的血25(OH)维生素D3水平显著提高(33.13~39.49 nmol/L),而对照组则维持不变(29.27~28.21 nmol/L)。HCM组的血CTX水平在0 w和2 w之间下降了25%,并保持不变直至第12w。从第2w开始HCM组和对照组相比血CTX水平就出现了显著差异(P<0.001)。结论通过饮用含高钙和维生素D的强化奶(HCM),在2至4w内能显著提高中国绝经妇女体内维生素D水平,并减少骨吸收破坏。如果长期持续地饮用含高钙和维生素D的强化奶(HCM),能减少骨吸收和骨量丢失的风险,从而减少患骨质疏松和由此引起骨折的风险。 | Marlena C Kruger PengCheng Ha Joanne M Todd Barbara Kuhn-Sherlock Linda M Schollum Jiliang Ma George Qin Edith Lau | 2013 | 中国骨质疏松杂志2013，19，2： | 2 |
| 8 | Management of neuroblastoma in limited-resource settings显示文摘BACKGROUND Neuroblastoma(NB)is a heterogeneous disease with variable outcomes among countries.Little is known about NB in low-and middle-income countries(LMICs).AIM The aim of this review was to evaluate regional management protocols and challenges in treating NB in paediatric oncology units in LMICs compared to high-income countries(HICs).METHODS PubMed,Global Health,Embase,SciELO,African Index Medicus and Google Scholar were searched for publications with keywords pertaining to NB,LMICs and outcomes.Only English language manuscripts and abstracts were included.A descriptive review was done,and tables illustrating the findings were constructed.RESULTS Limited information beyond single-institution experiences regarding NB outcomes in LMICs was available.The disease characteristics varied among countries for the following variables:sex,age at presentation,MYCN amplification,stage and outcome.LMICs were found to be burdened with a higher percentage of stage 4 and high-risk NB compared to HICs.Implementation of evidence-based treatment protocols was still a barrier to care.Many socioeconomic variables also influenced the diagnosis,management and followup of patients with NB.CONCLUSION Patients presented at a later age with more advanced disease in LMICs.Management was limited by the lack of resources and genetic studies for improved NB classification.Further research is needed to develop modified diagnostic and treatment protocols for LMICs in the face of limited resources. | Jaques van Heerden Mariana Kruger | 2020 | World Journal of Clinical Oncology2020，11，8： | 2 |
| 9 | Global review and synthesis of trends in observed terrestrial near-surface wind speeds: Implications for evaporation显示文摘 | Tim R. McVicar Michael L. Roderick Randall J. Donohue Ling Tao Li Thomas G. Van Niel Axel Thomas Jürgen Grieser Deepak Jhajharia Youcef Himri Natalie M. Mahowald Anna V. Mescherskaya Andries C. Kruger Shafiqur Rehman Yagob Dinpashoh | 2011 | Journal of Hydrology2011，，： | 2 |
| 10 | Two-Year Outcomes of the Ranibizumab for Edema of the mAcula in Diabetes (READ-2) Study显示文摘 | Quan Dong Nguyen Syed Mahmood Shah Afsheen A. Khwaja Roomasa Channa Elham Hatef Diana V. Do David Boyer Jeffery S. Heier Prema Abraham Allen B. Thach Eugene S. Lit Bradley S. Foster Erik Kruger Pravin Dugel Thomas Chang Arup Das Thomas A. Ciulla John S. P | 2010 | Ophthalmology2010，，11： | 2 |
| 11 | Composite prognostic models across the non-alcoholic fatty liver disease spectrum: Clinical application in developing countries显示文摘Heterogeneity in clinical presentation, histological severity, prognosis and therapeutic outcomes characteristic of non-alcoholic fatty liver disease(NAFLD) necessitates the development of scientifically sound classification schemes to assist clinicians in stratifying patients into meaningful prognostic subgroups. The need for replacement of invasive liver biopsies as the standard method whereby NAFLD is diagnosed, graded and staged with biomarkers of histological severity injury led to the development of composite prognostic models as potentially viable surrogate alternatives. In the present article, we review existing scoring systems used to(1) confirm the presence of undiagnosed hepatosteatosis;(2) distinguish between simple steatosis and NASH; and(3) predict advanced hepatic fibrosis, with particular emphasis on the role of NAFLD as an independent cardio-metabolic risk factor. In addition, the incorporation of functional genomic markers and application of emerging imaging technologies are discussed as a means to improve the diagnostic accuracy and predictive performance of promising composite models found to be most appropriate for widespread clinical adoption. | Hilmar K Lückhoff Frederik C Kruger Maritha J Kotze | 2015 | World Journal of Hepatology2015，7，9： | 2 |
| 12 | On-target temporal characterization of optical pulses at relativistic intensity显示文摘High-field experiments are very sensitive to the exact value of the peak intensity of an optical pulse due to the nonlinearity of the underlying processes.Therefore,precise knowledge of the pulse intensity,which is mainly limited by the accuracy of the temporal characterization,is a key prerequisite for the correct interpretation of experimental data.While the detection of energy and spatial profile is well established,the unambiguous temporal characterization of intense optical pulses,another important parameter required for intensity evaluation,remains a challenge,especially at relativistic intensities and a few-cycle pulse duration.Here,we report on the progress in the temporal characterization of intense laser pulses and present the relativistic surface second harmonic generation dispersion scan(RSSHG-D-scan)—a new approach allowing direct on-target temporal characterization of high-energy,few-cycle optical pulses at relativistic intensity. | Vyacheslav E.Leshchenko Alexander Kessel Olga Jahn Mathias Kruger Andreas Münzer Sergei ATrushin Laszlo Veisz Zsuzsanna Major Stefan Karsch | 2019 | Light(Science & Applications)2019，8，1： | 2 |
| 13 | Repeat hepatectomy for recurrent colorectal liver metastases:A comparative analysis of short-and long-term results显示文摘Background: Liver recurrence after resection of colorectal liver metastases(CRLM) is frequent. Repeat hepatectomy has been shown to have satisfactory perioperative results. However, the long-term outcomes and the benefts for patients with early recurrence have not been clarifed. The aim of this study was to compare the short-and long-term outcomes of patients undergoing single hepatectomy and repeat hepatectomy for CRLM. Additionally, the oncological outcomes of patients with early( ≤ 6 months) and late recurrence who underwent repeat hepatectomy were compared. Methods: Consecutive adult patients undergoing hepatectomy for CRLM between June 20 0 0 and February 2020 were included and divided into two groups: single hepatectomy and repeat hepatectomy. Results: A total of 709 patients were included: 649 in the single hepatectomy group and 60 in the repeat hepatectomy group. Patients in the repeat hepatectomy group underwent more cycles of preoperative chemotherapy [4(3-6) vs. 3(2-4), P = 0.003]. Patients in the single hepatectomy group more frequently underwent major hepatectomies(34.5% vs. 16.7%, P = 0.004) and had a greater number of lesions resected(2.9 ± 3.6 vs. 1.9 ± 1.8, P = 0.011). There was no increase in operative time, estimated blood loss, length of hospital stay, complications, or mortality in the repeat hepatectomy group. There were no differences in overall survival( P = 0.626) and disease-free survival( P = 0.579) between the two groups. Similarly, for patients underwent repeat hepatectomy, no difference was observed between the early and late recurrence groups in terms of overall survival( P = 0.771) or disease-free survival( P = 0.350). Conclusions: Repeat hepatectomy is feasible and safe, with similar short-and long-term outcomes when compared to single hepatectomy. Surgical treatment of early liver recurrence offers similar oncological outcomes to those obtained for late recurrence. | Paulo Figueiredo Costa Fabricio Ferreira Coelho Vagner Birk Jeismann Jaime Arthur Pirola Kruger Gilton Marques Fonseca Ivan Cecconello Paulo Herman | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，2： | 2 |
| 14 | Statin therapy is associated with fewer deaths in patients with bacteraemia显示文摘 | Peter Kruger Kenneth Fitzsimmons David Cook Mark Jones Graeme Nimmo | 2006 | Intensive Care Medicine2006，，1： | 2 |
| 15 | Ala 39 Pro mutation in the gene encoding α-synuclein in Parkinson's disease显示文摘 | Kruger R Kuhn W Muller T | | 0，，： | 2 |
| 16 | The effect of pregnancy on hiatal dimensions and urethral mobility: an observational study显示文摘 | Ka Lai Shek Jenny Kruger Hans Peter Dietz | 2012 | International Urogynecology Journal2012，，11： | 2 |
| 17 | A whole seed assay for polyphenol oxidase in Canadian prairie spring wheats and its usefulness as a measure of noodle darkening 显示文摘 | Kruger J E Hatcher D W DePauw R | 1994 | Cereal Chemistry1994，71，： | 1 |
| 18 | Regulation of neutrophil activation in acute lung injury显示文摘 | Downey GP Dong Q Kruger J | 1999 | Chest1999，116，1： | 1 |
| 19 | Cystathionine beta-synthase deficiency in Georgia(USA) ; correlation of clinical and biochemical phenotype with genotype 显示文摘 | Kruger W D Wang L Jhee Kee | 2003 | Hum Mutat2003，22，6： | 1 |
| 20 | Augmentation of non-specific protection in African catfish, Clarias gariepinus (Burchell), by the long-term oral administration of immunostimulants显示文摘 | Yoshida T Kruger R Inglis V | 1995 | Journal of Fish Diseases1995，18，： | 1 |
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