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| 1 | Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability显示文摘Co-amorphous solid dispersion(C-ASD)systems have attracted great attention to improve the solubility of poorly soluble drugs,but the selection of an appropriate stabilizer to stabilize amorphous forms is still a huge challenge.Herein,C-ASD system of two clinical combined used drugs(lacidipine(LCDP)and spironolactone(SPL))as stabilizers to each other,was prepared by solvent evaporation method.The effects of variation in molar ratio of LCDP and SPL(3:1,1:1,1:3,1:6,and 1:9)on the drug release characteristics were explored.Polarized light microscopy(PLM),powder X-ray diffraction(PXRD),differential scanning calorimetry(DSC)and thermogravimetric analysis(TGA)were employed to evaluate the solid states.Prepared C-ASDs were further studied for their stability under the high humidity(RH 92.5%).Further analysis of C-ASDs via Fourier-transform infrared spectroscopy(FTIR)and Raman spectroscopy confirmed that hydrogen bond interactions between the two drugs played a significant role in maintaining the stability of the C-ASDs systems.Moreover,molecular dynamic(MD)simulations provided a clear insight into the stability mechanism at the molecular level.This study demonstrated the novel drug-drug C-ASDs systems is a promising formulation strategy for improved dissolution rate and enhanced physical stability of poorly soluble drugs. | Zhaomeng Wang Mengchi Sun Tian Liu Zisen Gao Qing Ye Xiao Tan Yanxian Hou Jin Sun Dun Wang Zhonggui He | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，1： | 2 |
| 2 | Emerging systemic delivery strategies of oncolytic viruses:A key step toward cancer immunotherapy显示文摘Oncolytic virotherapy(OVT)is a novel type of immunotherapy that induces anti-tumor responses through selective self-replication within cancer cells and oncolytic virus(OV)-mediated immunostimulation.Notably,talimogene laherparepvec(T-Vec)developed by the Amgen company in 2015,is the first FDA-approved OV product to be administered via intratumoral injection and has been the most successful OVT treatment.However,the systemic administration of OVs still faces huge challenges,including in vivo pre-existing neutralizing antibodies and poor targeting delivery efficacy.Recently,state-of-the-art progress has been made in the development of systemic delivery of OVs,which demonstrates a promising step toward broadening the scope of cancer immunotherapy and improving the clinical efficacy of OV delivery.Herein,this review describes the general characteristics of OVs,focusing on the action mechanisms of OVs as well as the advantages and disadvantages of OVT.The emerging multiple systemic administration approaches of OVs are summarized in the past five years.In addition,the combination treatments between OVT and traditional therapies(chemotherapy,thermotherapy,immunotherapy,and radiotherapy,etc.)are highlighted.Last but not least,the future prospects and challenges of OVT are also discussed,with the aim of facilitating medical researchers to extensively apply the OVT in the cancer therapy. | Weiyue Ban Jianhuan Guan Hanwei Huang Zhonggui He Mengchi Sun Funan Liu Jin Sun | 2022 | Nano Research2022，15，5： | 2 |
| 3 | Presenting XML schema mapping with conjunctive-disjunctive views显示文摘 | LI Xuhui ZHU Shanfeng LIU Mengchi | 2013 | Web-Age Information Management Lecture Notes in Computer Science2013，7923，： | 1 |
| 4 | ROL:A Deductive Object Based Language显示文摘 | Mengchi Liu | 1996 | Information systems1996，21，5： | 1 |
| 5 | Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metastatic breast tumors显示文摘Substantial progress in the use of chemo-photodynamic nano-drug delivery systems(nanoDDS) for the treatment of the malignant breast cancer has been achieved. The inability to customize precise nanostructures, however, has limited the therapeutic efficacy of the prepared nano-DDS to date. Here,we report a structurally defined tandem-responsive chemo-photosensitive co-nanoassembly to eliminate primary breast tumor and prevent lung metastasis. This both-in-one co-nanoassembly is prepared by assembling a biocompatible photosensitive derivative(pheophorbide-diphenylalanine peptide, PPADA) with a hypoxia-activated camptothecin(CPT) prodrug [(4-nitrophenyl) formate camptothecin, NCPT]. According to computational simulations, the co-assembly nanostructure is not the classical core-shell type, but consists of many small microphase regions. Upon exposure to a 660 nm laser,PPA-DA induce high levels of ROS production to effectively achieve the apoptosis of normoxic cancer cells. Subsequently, the hypoxia-activated N-CPT and CPT spatially penetrate deep into the hypoxic region of the tumor and suppress hypoxia-induced tumor metastasis. Benefiting from the rational design of the chemo-photodynamic both-in-one nano-DDS, these nanomedicines exhibit a promising potential in the inhibition of difficult-to-treat breast tumor metastasis in patients with breast cancer. | Mengchi Sun Hailun Jiang Tian Liu Xiao Tan Qikun Jiang Bingjun Sun Yulong Zheng Gang Wang Yang Wang Maosheng Cheng Zhonggui He Jin Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 6 | ROL:A Deductive Object Base Language显示文摘 | LIU Mengchi | 1996 | Information System1996，，21： | 1 |
| 7 | One-photo excitation pathway in 2D in-plane heterostructures for effective visible-light-driven photocatalytic degradation显示文摘Broad-spectrum absorption and highly effective charge-carrier separation are two essential requirements to improve the photocatalytic performance of semiconductor-based photocatalysts.In this work,a fascinating one-photon system is reported by rationally fabricating 2D in-plane Bi_(2)O_(3)/BiOCl(i-Cl)heterostructures for efficient photocatalytic degradation of RhB and TC.Systematic investigations revealed that the matched band structure generated an internal electric field and a chemical bond connection between the Bi_(2)O_(3)and BiOCl in the Bi_(2)O_(3)/BiOCl composite that could effectively improve the utilization ratio of visible light and the separation effectivity of photo-generated carriers in space.The formed interactions at the 2D in-plane heterojunction interface induced the one-photon excitation pathway which has been confirmed by the experiment and DFT calculations.As a result,the i-Cl samples showed significantly enhanced photocatalytic efficiency towards the degradation of RhB and TC(RhB:0.106 min^(-1);TC:0.048 min^(-1))under visible light.The degradation activities of RhB and TC for i-Cl were 265.08 and 4.08times that of pure BiOCl,as well as 9.27 and 2.14 times that of mechanistically mixed Bi_(2)O_(3)/BiOCl samples,respectively.This work provides a logical strategy to construct other 2D in-plane heterojunctions with a one-photon excitation pathway with enhanced performance. | Mengchi Liu Yiwen Cheng Yuee Xie Yingcong Wei Jinhui Xing Yuanping Chen Jing Xu | 2023 | Journal of Semiconductors2023，44，5： | 0 |
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