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| 1 | 肝内胆管细胞癌和转移性胰腺导管腺癌的免疫组化鉴别显示文摘在肝脏活检标本中,原发性肝内胆管细胞癌(ICC)和转移性胰腺导管腺癌(PDA)组织学上难以区分,但二者的鉴别具有重要的临床意义。本组实验对41例ICCs和60例PDAs分别进行SLOOP、pVHL、IMP3、肿瘤抑制基因蛋白maspin、MUC5AC及CKl7蛋白的免疫表型评估,以了解这些标志物在两种疾病鉴别诊断中的价值。结果显示:29例(71%)ICCs表达pVHL,PDAs中仅3例(5%)出现pVHL表达。S100P、MUC5AC和CKl7在PDAs中阳性率较高,分别为57例(95%)、40例(67%)和36例(60%),ICCs中S100P、MUC5AC和CK17分别为11例(27%)、5例(12%)及5例(12%)表达。IMP3在ICCs和PDAs中阳性率均为90%。60例(100%)PDA和30例(73%)ICC患者存在maspin的阳性表达。作者对上述标志物表达情况进行归纳后发现,当免疫组化染色结果呈SLOOP-/pVHL+/MUC5AC-/CK17-时提示ICC,呈SLOOP+/pVHL-/MUC5AC+/CK17+和S100P+/pVHL-/MUC5AC-/CK17+时则提示PDA。据此可有效将ICC和PDA鉴别开来。 | Lok T Chen L Lin F 王慧 余英豪 | 2014 | 临床与实验病理学杂志2014，30，10： | 3 |
| 2 | Simplified design of rock cavern concrete lining to resist shock loading显示文摘一个简化方法对装载的吃惊在地下的岩石大洞 / 隧道为具体衬里的设计被建议。装载可以在地面表面或邻近大洞 / 隧道的爆炸的地面穿入射弹上源于炸药的爆炸。产生问题要求一致地在跨度上散布的一个短暂压力装载的一根横梁的动力学的答案。根据有岩石门栓和 shotcrete 的系统的机械特征,一个动态支持设计方法基于自由(SDOF ) 的相等的单个度被提出。SDOF 方法被用于获得最大的排水量在横梁中间跨度,它经常是在强风抵抗的设计的控制因素。在这个问题的明确的表达,建议方法联合 spalling 和结构的动力学理论的现象。一个例子被提供表明这个简化方法的适用性。 | ZHAO P J LOK T S 殷志强 周子龙 | 2010 | Journal of Central South University2010，17，5： | 3 |
| 3 | Effect of calcium-based versus non-calcium-based phosphate binders on mortality in patients with chronic kidney disease: an updated systematic review and meta-analysis显示文摘 | Sophie A Jamal Ben Vandermeer Paolo Raggi David C Mendelssohn Trish Chatterley Marlene Dorgan Charmaine E Lok David Fitchett Ross T Tsuyuki | 2013 | The Lancet2013，，： | 2 |
| 4 | Aluminophosphate molecular sieves : a new class of microporous crystalline inorganic solids显示文摘 | Wilson S T Lok B M Messina C A | 1982 | J Am Chem Soc1982，104，4： | 1 |
| 5 | Dynamic characteristics of granite subjected to intermediate loading rate显示文摘 | LI X B LOK T S ZHAO J | 2005 | Rock Mechanics and Rock Engineering2005，38，1： | 1 |
| 6 | Provision of continuous VCR functions in interactive broadcast VoD systems 显示文摘 | POON W F LOK T FENG J | 2005 | IEEE Transition Broadcasting2005，51，4： | 1 |
| 7 | Free vibration of clampeo orthotropic sandwich panel显示文摘 | LOK T S CHENG Q H | 2000 | Journal of Sound and Vibration2000，229，2： | 1 |
| 8 | The role of organic molecules in molecular sieve synthesis显示文摘 | Lok B M Cannan T R Messina C A | 1983 | Zeolites1983，，3： | 1 |
| 9 | Aberrant activation of ERK/FOXM1 signaling cascade triggers the cell migration/invasion in ovarian cancer cells显示文摘 | LOK G T CHAN DW LIU V W | 2011 | PloS One2011，6，23： | 1 |
| 10 | Optimal hemodi- alysis vascular access in the elderly patient显示文摘 | Moist L Lok C Vachharajani T | 2012 | Semin Dial2012，25，6： | 1 |
| 11 | Testing and response of large diameter brittle materials subjected to high strain rate显示文摘 | Lok T S LiX B Liu D Zhao P J | 2002 | Journal of Materials in Civil Engineering2002，，14： | 1 |
| 12 | Predictive value o plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction 显示文摘 | de Boer RA Lok D J Jaarsma T | 2011 | Ann Med2011，43，1： | 1 |
| 13 | Aluminophosphate molecular sieves: a new class of microporous crystalline inorganic solids显示文摘 | Wilson S T Lok B M Messina C A | 1982 | J Am Chem Soc1982，104，： | 1 |
| 14 | Using the Hopkinson Pressure Bar to Investigate the Dynamic Behaviour of SFRC显示文摘 | Lok T S Zhao P J Lu G | 2003 | Magazine of Concrete Research2003，55，2： | 1 |
| 15 | Using the split Hopkinson pressure bar to investigate the dynamic behaviour of SFRC显示文摘 | Lok T S Zhao P J Lu G | 2003 | Magazine of Concrete Research2003，55，2： | 1 |
| 16 | A hybrid particle swarm optimization-back-propagation algorithm for feedforward neural network training显示文摘 | ZHANG J R ZHANG J LOK T M | 2007 | Applied Mathematics and Computa- tion2007，185，2： | 1 |
| 17 | Predictive value of plasma galectin-3 levels in heart failure with reduced and preserved ejection fraction显示文摘 | de Boer RA Lok DJ Jaarsma T | | 0，，01： | 1 |
| 18 | Economic performance of industrial development on collective land in the urbanization process in China: empirical evidence from Shenzhen显示文摘 | Choy L H T Lai Y Lok W | 2013 | Habitat International2013，，40： | 1 |
| 19 | Flexural behavior of steel fiber reinforced concrete 显示文摘 | LOK T S PEI J S | 1998 | ASCE Journal of Materials in Civil Engineering1998，10，2： | 1 |
| 20 | Asynchronous multiple-access interference suppression and chip waveform selection with aperiodic random sequences显示文摘 | Wong T T Lok T M Lehnert J S | 1999 | IEEE Trans Commun1999，47，1： | 1 |
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