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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Kuhn Algorithm: Ullla- convenient Solver to Complex Polynomial and Transcendental Equations without Initial Value Selection 显示文摘 | Yunliang Long Edward K N Yung | 2002 | International Journal of RF and Microwave Computer-Aided Engineering2002，12，6： | 1 |
| 3 | Metal alkynyl σ complexes:synthesis and materials显示文摘 | Long N L Williams C K | 2003 | Angew Chem Int Ed2003，42，： | 1 |
| 4 | Gender and tuberculosis control: Perspectives on health seeking be- haviour among men and women in Vietnam 显示文摘 | Johansson E Long N H Diwan V K | 2000 | Health Policy2000，52，1： | 1 |
| 5 | Light-stimulated protein movement in rod photoreceptor cell of the rat retina显示文摘 | PHILP N J CHANG W LONG K | 1987 | FEBS Letters1987，225，： | 1 |
| 6 | A confidence limit for the Empirical Mode Decomposition and Hilbert Spectral Analysis显示文摘 | Huang N E Wu M L Long S R Shen S S Qu W D Gloersen p and Fan K L | 2003 | Proceedings Royal Society of London2003，459，： | 1 |
| 7 | Existence and stability of solutions for generalized strong vector quasi-equilibrium problem显示文摘 | LONG X J HUANG N J TEO K L | 2008 | Mathematical and Computer Modeling2008，47，： | 1 |
| 8 | A framework for three-dimensional mesoscale modeling of anisotropic swelling and mechanical deformation in lithium-ion electrodes显示文摘 | Roberts S A Brunini V E Long K N | 2014 | Journal of the Electrochemical Society2014，161，11： | 1 |
| 9 | Fertility considerations in the management of gynecologic malignancies 显示文摘 | Noyes N Knopman JM Long K | 2011 | Gynecol Oncol2011，120，3： | 1 |
| 10 | Phylogenetic analysis of the DNA sequence of the non - coding region of nuclear ribosomal DNA and chloroplast of Ephedra plants in China 显示文摘 | Long C Kakiuchi N Takahashi A Komatsu K Cai S Mikage M | 2004 | Planta Medica2004，70，11： | 1 |
| 11 | ZF-CxxC domain-containing proteins, CpG islands and the chromatin cormection显示文摘 | Long H K Blackledge N P Klose R J | 2013 | Biochem Soc Trans2013，41，3： | 1 |
| 12 | Existence and stability of solutions for generalized vector quasiequilibrium problem显示文摘 | Long X J Huang N J Teo K L | 2008 | Mathematical and Computer Modeling2008，47，： | 1 |
| 13 | A scalable limited feedback design for network MIMO using per-cell product eodebook显示文摘 | Cheng Yong Lau K N and Long Yi | 2010 | IEEE Tansactions2010，9，10： | 1 |
| 14 | A plant flavone, luteolin, induces expression of Rhizobium meliloti nodulation genes 显示文摘 | PETERS N K FROST J W LONG S R | 1986 | Science1986，233，4767： | 1 |
| 15 | Kuhn algorithm:ultraconvenient solver to complex polynomial and transcendental equations without initial value selection显示文摘 | YUNG E K N | 2002 | Int J RF and Microwave Computer-Aided Eng2002，12，6： | 1 |
| 16 | Hispidacine,an unusual 8,4'-oxyneolignan-alkaloid with vasorelaxant activity,and hispiloscine,an antiproliferative phenanthroindolizidine alkaloid,from Ficus hispida Linn显示文摘 | Yap V A Long B J Ting K N | 2015 | Phytochem2015，109，： | 1 |
| 17 | Modeling and optinfization of lipozyme RM IM- catalyzed esterification of medium- and long- chain triacyglycerols (MLCT) using response surface methodology显示文摘 | Arifin N Soo- Peng K Long K | 2012 | Food and Bioprocess Technology2012，5，1： | 1 |
| 18 | Role of N-linked glycosylation in the secretion and activity of endothelial lipase显示文摘 | Miller G C Long C J Bojilova E D Marchadier D Badellino K 0 Blanchard N Fuki I V Glick J M Rader D J | 2004 | Journal of Lipid Research2004，45，11： | 1 |
| 19 | Photo-induced deformation of active polymer films : Single spot irradiation显示文摘 | LONG K N SCOTT T F DUNN M L | 2011 | International Journal of Solids and Structures2011，48，1415： | 1 |
| 20 | Welfare effects of reducing home bias in government procurements: A dynamic contest model显示文摘 | Fujiwara K Van Long N | 2012 | Review of Development Economics2012，，16： | 1 |
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