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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | 饲料中添加蛋白酶对肉鸡性能、养分利用率、肠道形态和胴体品质的影响显示文摘试验在饲喂玉米、高粱为主的肉鸡日粮中补充大豆,并添加蛋白酶,研究蛋白酶对肉鸡性能、养分消化率、肠道形态和胴体品质的影响。试验选取1日龄AA肉仔鸡(43.8±1.31 g)256只,均为公鸡,随机分配到2×2试验设计方阵中,方阵包括正常组(玉米组和高粱组)和蛋白酶组(空白组和添加蛋白酶150 mg·kg^(-1)的试验组)。试验1~21 d为第一阶段,22~42 d为第二阶段。试验结果表明,第二阶段中,日粮中添加蛋白酶极显著提高肉鸡的平均日增重(ADG,P<0.01),在整个试验过程中显著提高(P<0.05)。在各个时期,正常组对肉鸡生产性能均无显著影响(P>0.05)。19~21 d时,添加蛋白酶可显著提高肉鸡的表观代谢能(AME),干物质(DM)、总能量(GE)和养分消化率(P<0.05)。此外,日粮以高粱为主时,AME、GE消化率有降低趋势(P=0.05),氮沉积率也有降低趋势(P=0.08)。40~42 d时,日粮中添加蛋白酶可显著提高AME,DM、GE和氮沉积率(P<0.05)。21 d时,日粮中添加蛋白酶极显著增加肠绒毛高度、肠绒毛与隐窝深度比值,极显著降低十二指肠、空肠、回肠的隐窝深度(P<0.01)。42 d时,日粮中添加蛋白酶显著增加空肠肠绒毛高度、绒毛高度与隐窝深度比值,显著降低隐窝深度(P<0.05)。日粮中添加蛋白酶显著增加胸肌重、24 h p H,显著降低胸肌的滴水损失(P<0.05)。试验结果表明,饲养阶段日粮中添加复合蛋白酶可提高肉鸡ADG;在第一阶段可改善AME、DM、GE和氮沉积率和肠道形态。补充蛋白酶可提高出栏重、胸肌重和24 h pH,降低胸肌的滴水损失。低单宁高粱日粮与玉米日粮相比,对肉鸡性能的影响相近。 | Xu X Wang H L Pan L Ma X K Tian Q Y Xu Y T Long S F Zhang Z H Piao X S | 2017 | 饲料博览2017，0，1： | 2 |
| 3 | The potential for resistance to Botrytis cinerea by kiwifruit显示文摘 | Wurms K V Long P G Sharrock K R | 1999 | Crop Protection1999，18，： | 1 |
| 4 | A selective optode membrane for histidine based on fluorescence enhancement of meso-meso-linked porphyrin dimer显示文摘 | Yang R Wang K Long L | 2002 | Anal xtical Chemistry2002，74，5： | 1 |
| 5 | The effect of 03 fumigation during leaf development on photosynthesis of wheat and pea: An invivo analysis 显示文摘 | Farage P K Long S P | 1999 | Photosynthesis Research1999，59，： | 1 |
| 6 | Measurement of leaf and canopy photosynthetic C02 exchange in the field显示文摘 | Farageand P K Garcia R L | 1996 | Journal of Experimental Botany1996，47，304： | 1 |
| 7 | Kuhn Algorithm: Ullla- convenient Solver to Complex Polynomial and Transcendental Equations without Initial Value Selection 显示文摘 | Yunliang Long Edward K N Yung | 2002 | International Journal of RF and Microwave Computer-Aided Engineering2002，12，6： | 1 |
| 8 | The final acylation step in taxol biosynthesis:Cloning of the taxoid C13-sidechain N-benzoyltransferase from Taxus显示文摘 | WALKER K LONG R CROTEAU R | 2002 | Proceedings of the National Academy of Sciences2002，99，14： | 1 |
| 9 | Molecular cloning and heterologous expression of the C-13 phenylpropanoid side chain- CoA acytransferase that functions in taxol biosynthesis 显示文摘 | Walker K Fujisaki S Long R M | 2002 | Proc Natl Acad Sci USA2002，99，12： | 1 |
| 10 | Comparative pharmacology of endothelium-derived relaxing factor and nitric oxide显示文摘 | SHIKANO K LONG C J OHLSTEIN E H | | 0，，3： | 1 |
| 11 | UV and blue light Arabidopsis显示文摘 | Jenkins G I Long J C Wade H K | | 0，，： | 1 |
| 12 | The changing face of community supported agriculture显示文摘 | LONG K B | 2010 | Culture and agriculture2010，32，1： | 1 |
| 13 | Some physicochemical properties of Moringa oleifera seed oil extracted using solvent and aqueous enzymatic methods 显示文摘 | Abdulkarim S M Long K Lai O M | 2005 | Food Chemistry2005，93，1： | 1 |
| 14 | Design of pore and matter ar- chitectures in manganese oxide charge-storage materials 显示文摘 | LONG J W SWIDER-LYONS K E | 2000 | Elec- trochem Solid-State Lett2000，3，： | 1 |
| 15 | Foamed Bitumen Mixes = Shear Performance? 显示文摘 | JENKINS K J LONG F M EBELS L J | 2007 | International Journal of Pavement Engineering2007，8，2： | 1 |
| 16 | Reducing accidental in- juries during surgery显示文摘 | Edlich RF Long WB 3rd Gubler K | 2010 | J Environ Pathol Toxico] Onco12010，29，4： | 1 |
| 17 | Genome shuffling of Megasphaera elsdenii for improving acid-tolerance and propionate production显示文摘 | Long M Li P Zhang W K etal | 2012 | African Journal of Microbi- ology Research2012，6，18： | 1 |
| 18 | Cardiac hypertrophy is positively regulated by MicroRNA miR - 23a显示文摘 | Wang K Lin ZQ Long B | 2012 | J Biol Chem2012，287，1： | 1 |
| 19 | CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation显示文摘 | Wang K Long B Zhou L | 2014 | Nat Commun2014，5，： | 1 |
| 20 | A NQR study of the crystalline structure of TNT显示文摘 | DEAS R M GASKELL M J LONG K | 2004 | Proc SPIE2004，5415，510： | 1 |
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