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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity 显示文摘 | Shichijo S Keicho N Long H T | 2004 | Tissue Antigens2004，64，5： | 1 |
| 3 | Recent result in French research on reinforced earth显示文摘 | Schlosser F Long N T | 1974 | ASCE1974，100，03： | 1 |
| 4 | Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): Implications for nanoparticle neuro- toxicity 显示文摘 | Long T C Saleh N Tilton R D | 2006 | Environmental Science & Technology2006，40，14： | 1 |
| 5 | Biomechanics of the double rocker sole shoe: Gait kinematics and kinetics 显示文摘 | Long J T Klein J P Sirota N M | 2007 | J Biomech2007，40，13： | 1 |
| 6 | Object oriented unsteady vortex lattice method for flapping flight显示文摘 | Fritz T E Long L N | 2004 | Journal of Aircraft2004，41，6： | 1 |
| 7 | The co evolution of new organization forms 显示文摘 | LEVIN A Y LONG C P CARROLL T N | 1999 | Organization Science1999，10，5： | 1 |
| 8 | Finite element analysis of embankment failure on soft subsoil显示文摘 | CHAI J C MIURA N BERGADO D T LONG P V | 1997 | Geotechnical Engineering1997，28，2： | 1 |
| 9 | Distributed interference manage-ment in two-tier CDMA femtocell networks显示文摘 | DUY T N LONG B L EKRAM H | 2012 | IEEE Trans on Wire-less Commun2012，11，3： | 1 |
| 10 | The coevolution of new organizational forms显示文摘 | Lewin A Y Long C P Carroll T N | | 0，，10： | 1 |
| 11 | Acid and bile tolerance and cholesterol re- moval ability of lactobacilli strains 显示文摘 | Long M T Shah N P | 2005 | J Dairy Sci2005，88，1： | 1 |
| 12 | Continuous Selections,Collectively Fixed Points and Weak Knaster-Kuratowski-Mazurkiewicz Mappings in Optimization显示文摘 | Khanh P Q Long V S T Quan N H | | 0，，： | 1 |
| 13 | Immobilization on a nanomagnetic Co/C surface using ROM polymerization: Genera- tion of a hybrid material as support for a recyclable palladium catalyst 显示文摘 | SCH) LONG T R GRASS R N | 2010 | Advanced Functional Materials2010，20，： | 1 |
| 14 | Localization of the G protein βγ complex in living cells during chemotaxis显示文摘 | Jin T Zhang N Long Y | 2000 | Science2000，287，5455： | 1 |
| 15 | Ion-exchanged pillared clays for selective catalytic reduction of NO by ethylene in the presence of oxygen显示文摘 | Yang R T Tharappiwattanon N Long R Q | 1998 | Appl Catal B: Environ1998，19，3： | 1 |
| 16 | Lon-exchanged pillared clays for selective catalytic reduction of NO by ethylene in the presence of oxygen显示文摘 | YANG R T THARAPP1WATTANANON N LONG R Q | 1998 | Appl Catal B1998，19，34： | 1 |
| 17 | The coevolution of new organizational forms 显示文摘 | Lewin A Y Long C P Carroll T N | 1999 | Organization Science1999，10，5： | 1 |
| 18 | Recent result in French research on reinforced earth显示文摘 | SCHLOSSER F LONG N T | 1974 | Journal of the Construction Division ASCE1974，100，3： | 1 |
| 19 | Photo-induced deformation of active polymer films : Single spot irradiation显示文摘 | LONG K N SCOTT T F DUNN M L | 2011 | International Journal of Solids and Structures2011，48，1415： | 1 |
| 20 | Protective role of Toll-like receptor 4 during the initiation stage of cutaneous chemical carcinogenesis显示文摘 | YUSUF N NASTI T H LONG J A et a1 | 2008 | Cancer Res2008，68，： | 1 |
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