3篇
您的检索式：作者名="LOU Dingbo"
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| 1 | Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins显示文摘The emergence of SARS-CoV-2 has resulted in the COVID-19 pandemic,leading to millions of infections and hundreds of thousands of human deaths.The efficient replication and population spread of SARS-CoV-2 indicates an effective evasion of human innate immune responses,although the viral proteins responsible for this immune evasion are not clear.In this study,we identified SARS-CoV-2 structural proteins,accessory proteins,and the main viral protease as potent inhibitors of host innate immune responses of distinct pathways.In particular,the main viral protease was a potent inhibitor of both the RLR and cGAS-STING pathways.Viral accessory protein 0RF3a had the unique ability to inhibit STING,but not the RLR response.On the other hand,structural protein N was a unique RLR inhibitor.0RF3a bound STING in a unique fashion and blocked the nuclear accumulation of p65 to inhibit nuclear factor-KB signaling.3CL of SARS-CoV-2 inhibited K63-ubiquitin modification of STING to disrupt the assembly of the STING functional complex and downstream signaling.Diverse vertebrate STINGs,including those from humans,mice,and chickens,could be inhibited by 0RF3a and 3CL of SARS-CoV-2.The existence of more effective innate immune suppressors in pathogenic coronaviruses may allow them to replicate more efficiently in vivo.Since evasion of host innate immune responses is essential for the survival of all viruses,our study provides insights into the design of therapeutic agents against SARS-CoV-2. | Yajuan Rui Jiaming Su Si Shen Ying Hu Dingbo Huang Wenwen Zheng Meng Lou Yifei Shi Meng Wang Shiqi Chen Na Zhao Qi Dong Yong Cai Rongzhen Xu Shu Zheng Xiao-Fang Yu | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 1 |
| 2 | Preface显示文摘In March 2009,the Stainless Steel Business Unit integrated the departments of purchasing,manufacturing,sales and R & D within the Baoshan Iron & Steel Co.,Ltd.and the unit implemented the strategy that strongly enhanced its business performance,and became one of the best enterprises in | LOU Dingbo | 2010 | Baosteel Technical Research2010，4，1： | 0 |
| 3 | Development of ferritic stainless steel products at Baosteel显示文摘Ferritic stainless steel(FSS) for various applications was developed on the basis of Thermo-calc simulation.Alloy design,precipitate analysis and processing parameters optimization were carried out on the basis of the simulation results according to the technical requirements of the applications.These developed products have outstanding properties,such as mechanical strength,ductility,formability,weldability and corrosion resistance. Baosteel has formed a series of FSS products which will increase the profit of the company and enhance the product variety of stainless steel. | JIANG Laizhu SHI Guomin LOU Dingbo | 2010 | Baosteel Technical Research2010，4，1： | 0 |
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