|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ron receptor-dependent gene regulation in a mouse model of endotoxin-induced acute liver failure显示文摘BACKGROUND:Prior experimentation has shown that loss of the tyrosine kinase(TK) signaling domain of the Ron receptor leads to marked hepatocyte protection in a model of lipopolysaccharideinduced acute liver failure(ALF) in D-galactosamine(GalN)sensitized mice.The aim of this study was to identify the role of Ron in the regulation of hepatic gene expression.METHODS:Microarray analyses were performed on liver RNA isolated sequentially from wild-type(WT) and TK-/mice during the progression of ALF.Gene array data were validated using Western and immunohistochemistry analyses as well as with ex vivo culture systems.RESULTS:At baseline,101 genes were differentially expressed between WT and TK-/-livers,which regulate processes involved in hypoxia,proliferation,apoptosis and metabolism.One hour after ALF induction,WT livers exhibited increased cytokine expression compared to TK-/-livers,and after 4 hours,an induction of suppressor of cytokine signaling(SOCS) genes as well as JAK-STAT pathway activation were prominent in TK-/livers compared to controls.CONCLUSION:Our studies suggest a novel hepato-protective mechanism in Ron TK-/-mice wherein increased and sustained SOCS production and JAK-STAT activation in the hepatocyte may inhibit the destructive proinflammatory milieu and promote survival factors which blunt hepatic death and the ensuing development of ALF. | Rishikesh M Kulkarni Louis W Kutcher William D Stuart Daniel J Carson Mike A Leonis Susan E Waltz | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 3 |
| 2 | Synthesis of electrically conducting organic polymers: halogen derivatives of polyacetylene, (CH)x 显示文摘 | Shirakawa H Louis E J MacDiarmid A G | 1977 | Chemical Communication1977，，： | 2 |
| 3 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db / db Mice显示文摘 | Hong Chen Olga Charlat Louis A Tartaglia Elizabeth A Woolf Xun Weng Stephen J Ellis Nathan D Lakey Janice Culpepper Karen J More Roger E Breitbart Geoffrey M Duyk Robert I Tepper Jay P Morgenstern | 1996 | Cell1996，，3： | 2 |
| 4 | Designing flexible manipulators with the lowest natural frequency nearly independent of position显示文摘 | LOUIS J E JENNCHEN T MARC C | 1999 | IEEE Transaction on Robotics and Automation1999，15，4： | 1 |
| 5 | The developing cancer stem-cell model: clinical challenges and opportunities显示文摘 | Louis Vermeulen Felipe de Sousa e Melo Dick J Richel Jan Paul Medema | 2012 | Lancet Oncology2012，，： | 1 |
| 6 | Pressure infiltration of packed ceramic particulates by liquid metals显示文摘 | GARCIA-CORDOVILA C LOUIS E NARCISO J | 1999 | Acta Materialia1999，47，18： | 1 |
| 7 | Using real- world data tbr coverage and payment decisions: the ISPOR real- world data task force report 显示文摘 | LOUIS P G J PETER J N PENNIFER E | 2007 | Value Health2007，10，5： | 1 |
| 8 | Tracheostomal stenosis following laryngectomy显示文摘 | MYERS E N LOUIS J G | 1982 | Ann Otol Rhinol Laryngol1982，91，4： | 1 |
| 9 | Abrasive wear resistance of aluminium alloy/ceramic particulate composites 显示文摘 | GARCIA-CORDOVILLA C NARCISO J LOUIS E | 1996 | Wear1996，192，： | 1 |
| 10 | Linking Job Demands and Resources to Employee Engagement and Burnout: A Theoretical Extension and Meta-Analytic Test 显示文摘 | Crawford E R LePine J A Louis Rich B | 2010 | Journal of Applied Psychology2010，95，5： | 1 |
| 11 | 显示文摘 | Shirakawa H Louis E J MacDiarmid A G | 1977 | Journal of the Chemical Society Chemical Communications1977，，16： | 1 |
| 12 | Synthesis of electrically conducting organic polymers: Halogen deriva- tives of polyacetylene显示文摘 | Shirakawa H Louis E J MacDiarmid A G | 1977 | Chem Commun1977，16，： | 1 |
| 13 | Sequence diversity, re-productive isolation and species concepts in Saccha- romyces 显示文摘 | Liti G Barton D B H Louis E J | 2006 | Genetics2006，174，2： | 1 |
| 14 | Pressure infiltration in a reactive system: Packed SiC particulates infiltrated by pure silver with dissolved oxygen 显示文摘 | Narciso J Garci a - cordovilla C Louis E | 1997 | Acta Materialia1997，45，12： | 1 |
| 15 | Synthesis of electrically conducting organic polymers halogen derivatives o{ polyacetylene, (CH)J: 显示文摘 | Shirakawa H Louis E J Macdiarmid A G | 1977 | Journal of the Chemical SocietyChemical Communications1977，16，： | 1 |
| 16 | Anomalies of the inferior vena cava显示文摘 | Mayo J Gray R St Louis E | 1983 | AJR Am J Roentgenol1983，140，2： | 1 |
| 17 | A comparison of different bedside tests for essential tremor显示文摘 | Louis E D Ford B Wendt K J | 1999 | Mov Disord1999，14，3： | 1 |
| 18 | Nature of Star-shaped Clusters of FeAl3 in Aluminum-iron Alloys显示文摘 | Louis E Mora R Pastor J | 1980 | Metal Science1980，12，： | 1 |
| 19 | Thermal expansion behaviour of aluminum/SiC composites with bimodal particle distributions显示文摘 | Arpon R Molina J M Saravanan R A Garcia-Cordovilla C Louis E Narciso J | 2003 | Acta Mater2003，51，11： | 1 |
| 20 | Synthesis of electrically conducting organic polymers: halogen derivatives of polyacetylene, (CH)x 显示文摘 | Shirakawa H Louis E J MacDiarmid A G | 1977 | J Chem Soc Chem Commun1977，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员